|Dataset||GO Biological Process Annotations|
|Category||structural or functional annotations|
|Description||Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. (Gene Ontology, GO_0002542)|
|Downloads & Tools|
2 genes participating in the factor xii activation biological process from the curated GO Biological Process Annotations dataset.