extrinsic apoptotic signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. (Gene Ontology, GO_0097191)
External Link http://amigo.geneontology.org/amigo/term/GO:0097191
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Genes

93 genes participating in the extrinsic apoptotic signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ACVR1B activin A receptor, type IB
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BID BH3 interacting domain death agonist
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2
BOK BCL2-related ovarian killer
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CD27 CD27 molecule
CD70 CD70 molecule
CIB1 calcium and integrin binding 1 (calmyrin)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DEDD death effector domain containing
DEDD2 death effector domain containing 2
DIABLO diablo, IAP-binding mitochondrial protein
ERBB3 erb-b2 receptor tyrosine kinase 3
EYA2 EYA transcriptional coactivator and phosphatase 2
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGFR3 fibroblast growth factor receptor 3
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABARAP GABA(A) receptor-associated protein
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HIPK1 homeodomain interacting protein kinase 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL12A interleukin 12A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL33 interleukin 33
IL4 interleukin 4
IL6R interleukin 6 receptor
INHBA inhibin, beta A
ITGAV integrin, alpha V
ITM2B integral membrane protein 2B
JAK2 Janus kinase 2
KIAA0141 KIAA0141
KITLG KIT ligand
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LCN2 lipocalin 2
MCL1 myeloid cell leukemia 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOAP1 modulator of apoptosis 1
NF1 neurofibromin 1
NGF nerve growth factor (beta polypeptide)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP2 poly (ADP-ribose) polymerase 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PML promyelocytic leukemia
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SIVA1 SIVA1, apoptosis-inducing factor
SMAD3 SMAD family member 3
SORT1 sortilin 1
ST20 suppressor of tumorigenicity 20
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRADD TNFRSF1A-associated via death domain
WWOX WW domain containing oxidoreductase