extrinsic apoptotic signaling pathway via death domain receptors Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. (Gene Ontology, GO_0008625)
External Link http://amigo.geneontology.org/amigo/term/GO:0008625
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Genes

35 genes participating in the extrinsic apoptotic signaling pathway via death domain receptors biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BID BH3 interacting domain death agonist
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DEDD death effector domain containing
DEDD2 death effector domain containing 2
DIABLO diablo, IAP-binding mitochondrial protein
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
GABARAP GABA(A) receptor-associated protein
KIAA0141 KIAA0141
MOAP1 modulator of apoptosis 1
NF1 neurofibromin 1
NGF nerve growth factor (beta polypeptide)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SORT1 sortilin 1
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRADD TNFRSF1A-associated via death domain