excinuclease repair complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. (Gene Ontology, GO_0009380)
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Genes

8 proteins co-occuring with the excinuclease repair complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 1.37409
APRT adenine phosphoribosyltransferase 1.30121
XPC xeroderma pigmentosum, complementation group C 0.824041
ERCC1 excision repair cross-complementation group 1 0.821288
FEN1 flap structure-specific endonuclease 1 0.801562
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.680719
DHFR dihydrofolate reductase 0.539883
FOS FBJ murine osteosarcoma viral oncogene homolog 0.172201