eukaryotic translation initiation factor 3 complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. (Gene Ontology, GO_0005852)
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147 proteins co-occuring with the eukaryotic translation initiation factor 3 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
EIF5 eukaryotic translation initiation factor 5 2.7333
EIF4B eukaryotic translation initiation factor 4B 2.50469
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 2.38941
EIF3H eukaryotic translation initiation factor 3, subunit H 2.25509
EIF3F eukaryotic translation initiation factor 3, subunit F 2.18964
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.18079
EIF3C eukaryotic translation initiation factor 3, subunit C 2.14788
EIF3E eukaryotic translation initiation factor 3, subunit E 2.06777
EIF3G eukaryotic translation initiation factor 3, subunit G 1.94391
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.8064
EIF4E eukaryotic translation initiation factor 4E 1.79177
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.74956
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 1.64135
EIF3M eukaryotic translation initiation factor 3, subunit M 1.54687
PABPC1 poly(A) binding protein, cytoplasmic 1 1.53726
EIF3L eukaryotic translation initiation factor 3, subunit L 1.51525
PAIP1 poly(A) binding protein interacting protein 1 1.50001
EIF3K eukaryotic translation initiation factor 3, subunit K 1.4938
EIF5B eukaryotic translation initiation factor 5B 1.46608
CTIF CBP80/20-dependent translation initiation factor 1.24236
EIF5A eukaryotic translation initiation factor 5A 1.13932
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.099
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 1.0238
EEF2 eukaryotic translation elongation factor 2 0.993672
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.962627
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.924666
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.886089
DCP1A decapping mRNA 1A 0.870885
COPS5 COP9 signalosome subunit 5 0.868126
PAIP2B poly(A) binding protein interacting protein 2B 0.845155
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.831384
MIF4GD MIF4G domain containing 0.826336
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.8089
LGTN ligatin 0.802479
COPS7A COP9 signalosome subunit 7A 0.764982
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.759069
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.749546
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.746833
BZW2 basic leucine zipper and W2 domains 2 0.744574
RPS23 ribosomal protein S23 0.736014
EIF3B eukaryotic translation initiation factor 3, subunit B 0.725258
PAIP2 poly(A) binding protein interacting protein 2 0.721688
SLBP stem-loop binding protein 0.712795
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.706598
RPL24 ribosomal protein L24 0.699983
NGDN neuroguidin, EIF4E binding protein 0.685954
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 0.684644
RC3H2 ring finger and CCCH-type domains 2 0.675499
GBP3 guanylate binding protein 3 0.666827
FBXO32 F-box protein 32 0.661208
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.655172
DDRGK1 DDRGK domain containing 1 0.65001
DOHH deoxyhypusine hydroxylase/monooxygenase 0.598538
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.593072
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.587199
RPS6 ribosomal protein S6 0.560943
XRN1 5'-3' exoribonuclease 1 0.554318
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.551425
PNRC2 proline-rich nuclear receptor coactivator 2 0.542352
RPS2 ribosomal protein S2 0.537005
RPTOR regulatory associated protein of MTOR, complex 1 0.533309
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.531668
PCBP2 poly(rC) binding protein 2 0.529208
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.50879
ERI1 exoribonuclease 1 0.503506
CPN1 carboxypeptidase N, polypeptide 1 0.488923
DENR density-regulated protein 0.478038
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.478038
RPS5 ribosomal protein S5 0.475223
RPL13 ribosomal protein L13 0.470406
RPL23A ribosomal protein L23a 0.461599
PA2G4 proliferation-associated 2G4, 38kDa 0.459203
GCDH glutaryl-CoA dehydrogenase 0.454816
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.452825
RNF139 ring finger protein 139 0.450438
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.447259
RPS3 ribosomal protein S3 0.443689
RPS28 ribosomal protein S28 0.438146
DAZAP2 DAZ associated protein 2 0.43617
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.433012
TRPS1 trichorhinophalangeal syndrome I 0.418077
RPS26 ribosomal protein S26 0.414555
EIF4H eukaryotic translation initiation factor 4H 0.41143
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.408699
RHOBTB2 Rho-related BTB domain containing 2 0.402081
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.397811
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.39471
SSB Sjogren syndrome antigen B (autoantigen La) 0.390455
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 0.378507
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.377738
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.37045
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.369684
CSN1S1 casein alpha s1 0.365095
EIF4A1 eukaryotic translation initiation factor 4A1 0.358609
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.354802
UBE2B ubiquitin-conjugating enzyme E2B 0.337373
LAT linker for activation of T cells 0.332095
RING1 ring finger protein 1 0.323825
DHPS deoxyhypusine synthase 0.319328
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.314465
ATF5 activating transcription factor 5 0.30924
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.30924
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.30254
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.299569
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.296601
RPS20 ribosomal protein S20 0.292527
RPS9 ribosomal protein S9 0.283663
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.280716
CDK19 cyclin-dependent kinase 19 0.280349
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.27998
TRIM27 tripartite motif containing 27 0.278509
XPOT exportin, tRNA 0.2719
PURB purine-rich element binding protein B 0.271533
PARK2 parkin RBR E3 ubiquitin protein ligase 0.266042
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.26312
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.26166
UBE2A ubiquitin-conjugating enzyme E2A 0.261296
PDE4B phosphodiesterase 4B, cAMP-specific 0.258016
IPO13 importin 13 0.24424
RPL7A ribosomal protein L7a 0.243519
DAZ2 deleted in azoospermia 2 0.235607
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.234533
DAZ1 deleted in azoospermia 1 0.233101
RPS10 ribosomal protein S10 0.22173
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.216111
MX1 MX dynamin-like GTPase 1 0.206766
MAPK1 mitogen-activated protein kinase 1 0.202684
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.202346
EXT1 exostosin glycosyltransferase 1 0.197993
RRM2 ribonucleotide reductase M2 0.195353
TPP2 tripeptidyl peptidase II 0.193394
CSN2 casein beta 0.1921
YBX1 Y box binding protein 1 0.190814
RPLP0 ribosomal protein, large, P0 0.183935
RPS8 ribosomal protein S8 0.183328
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.181227
XPO5 exportin 5 0.178877
SEC23B Sec23 homolog B (S. cerevisiae) 0.178299
HDLBP high density lipoprotein binding protein 0.175188
TSPO translocator protein (18kDa) 0.174361
DCP2 decapping mRNA 2 0.172201
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.167856
RPS15 ribosomal protein S15 0.167366
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.165231
DCTN1 dynactin 1 0.164089
LSM1 LSM1, U6 small nuclear RNA associated 0.161068
ATL1 atlastin GTPase 1 0.160456