etilefrine-7350 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the etilefrine-7350 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AGFG1 ArfGAP with FG repeats 1
AHI1 Abelson helper integration site 1
AIM2 absent in melanoma 2
AK1 adenylate kinase 1
ALS2CL ALS2 C-terminal like
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATN1 atrophin 1
BCL3 B-cell CLL/lymphoma 3
BMP1 bone morphogenetic protein 1
CA9 carbonic anhydrase IX
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD79B CD79b molecule, immunoglobulin-associated beta
CD83 CD83 molecule
CHKB choline kinase beta
CLCN5 chloride channel, voltage-sensitive 5
CLEC11A C-type lectin domain family 11, member A
CLUAP1 clusterin associated protein 1
COL6A1 collagen, type VI, alpha 1
CSF1R colony stimulating factor 1 receptor
CUZD1 CUB and zona pellucida-like domains 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHRS2 dehydrogenase/reductase (SDR family) member 2
E2F4 E2F transcription factor 4, p107/p130-binding
ELOVL5 ELOVL fatty acid elongase 5
ESRRA estrogen-related receptor alpha
FAM120C family with sequence similarity 120C
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FH fumarate hydratase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GBP1 guanylate binding protein 1, interferon-inducible
GPC1 glypican 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GSTP1 glutathione S-transferase pi 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
HIST1H4E histone cluster 1, H4e
HLA-G major histocompatibility complex, class I, G
HOXC8 homeobox C8
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITGB4 integrin, beta 4
LHX6 LIM homeobox 6
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LMF1 lipase maturation factor 1
LRRC8E leucine rich repeat containing 8 family, member E
MAP2K5 mitogen-activated protein kinase kinase 5
MED16 mediator complex subunit 16
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCAPH2 non-SMC condensin II complex, subunit H2
NF2 neurofibromin 2 (merlin)
NOS1 nitric oxide synthase 1 (neuronal)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP214 nucleoporin 214kDa
PAOX polyamine oxidase (exo-N4-amino)
PCDHA9 protocadherin alpha 9
PCGF3 polycomb group ring finger 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PER3 period circadian clock 3
PGLYRP4 peptidoglycan recognition protein 4
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POU5F1B POU class 5 homeobox 1B
PRDX2 peroxiredoxin 2
PRPH peripherin
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PXN paxillin
RASAL2 RAS protein activator like 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SIX2 SIX homeobox 2
SNRK SNF related kinase
SOX9 SRY (sex determining region Y)-box 9
SSPN sarcospan
SSX1 synovial sarcoma, X breakpoint 1
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
STON1 stonin 1
SUGP1 SURP and G patch domain containing 1
TLR5 toll-like receptor 5
TNK1 tyrosine kinase, non-receptor, 1
TOP3A topoisomerase (DNA) III alpha
TOP3B topoisomerase (DNA) III beta
TPP1 tripeptidyl peptidase I
TROVE2 TROVE domain family, member 2
TTBK2 tau tubulin kinase 2
TTC33 tetratricopeptide repeat domain 33
UBXN6 UBX domain protein 6
USP20 ubiquitin specific peptidase 20
VAC14 Vac14 homolog (S. cerevisiae)
WNK1 WNK lysine deficient protein kinase 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF783 zinc finger family member 783
ZNRD1-AS1 ZNRD1 antisense RNA 1

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRE5 adhesion G protein-coupled receptor E5
AFAP1 actin filament associated protein 1
AMDHD2 amidohydrolase domain containing 2
AMPD2 adenosine monophosphate deaminase 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ATAD3A ATPase family, AAA domain containing 3A
ATXN2 ataxin 2
AXIN1 axin 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAHD1 bromo adjacent homology domain containing 1
BCAS1 breast carcinoma amplified sequence 1
BTBD2 BTB (POZ) domain containing 2
C5 complement component 5
CAPN15 calpain 15
CDK5 cyclin-dependent kinase 5
CEP97 centrosomal protein 97kDa
CSNK1E casein kinase 1, epsilon
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGAT1 diacylglycerol O-acyltransferase 1
DNAL4 dynein, axonemal, light chain 4
DNALI1 dynein, axonemal, light intermediate chain 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYSF dysferlin
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHA2 EPH receptor A2
ERCC4 excision repair cross-complementation group 4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXL6 F-box and leucine-rich repeat protein 6
FCHO1 FCH domain only 1
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11710 uncharacterized protein FLJ11710
FRS2 fibroblast growth factor receptor substrate 2
GPATCH2L G patch domain containing 2-like
GPR27 G protein-coupled receptor 27
GSTCD glutathione S-transferase, C-terminal domain containing
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC10 homeobox C10
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
ITPKB inositol-trisphosphate 3-kinase B
KDM5C lysine (K)-specific demethylase 5C
KRT24 keratin 24, type I
LIG4 ligase IV, DNA, ATP-dependent
LRRC20 leucine rich repeat containing 20
LRRC61 leucine rich repeat containing 61
LYPD1 LY6/PLAUR domain containing 1
MAPK8 mitogen-activated protein kinase 8
MATK megakaryocyte-associated tyrosine kinase
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCC mutated in colorectal cancers
MED9 mediator complex subunit 9
MITF microphthalmia-associated transcription factor
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTERF4 mitochondrial transcription termination factor 4
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCAM2 neural cell adhesion molecule 2
NEK11 NIMA-related kinase 11
NFRKB nuclear factor related to kappaB binding protein
NKX3-2 NK3 homeobox 2
NPY1R neuropeptide Y receptor Y1
NUP62CL nucleoporin 62kDa C-terminal like
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB3 protocadherin beta 3
PGP phosphoglycolate phosphatase
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RANBP17 RAN binding protein 17
RFTN1 raftlin, lipid raft linker 1
RNF31 ring finger protein 31
RPAP1 RNA polymerase II associated protein 1
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SLC12A8 solute carrier family 12, member 8
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STARD3 StAR-related lipid transfer (START) domain containing 3
STK16 serine/threonine kinase 16
TBC1D17 TBC1 domain family, member 17
TCTN1 tectonic family member 1
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
VASH1 vasohibin 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZMYM3 zinc finger, MYM-type 3
ZNF16 zinc finger protein 16
ZNF428 zinc finger protein 428
ZNF506 zinc finger protein 506
ZNF747 zinc finger protein 747
ZSCAN31 zinc finger and SCAN domain containing 31