etilefrine-4415 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the etilefrine-4415 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ADAM12 ADAM metallopeptidase domain 12
ADGRG2 adhesion G protein-coupled receptor G2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APAF1 apoptotic peptidase activating factor 1
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ASIC1 acid sensing (proton gated) ion channel 1
ATP10B ATPase, class V, type 10B
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BMP1 bone morphogenetic protein 1
C17ORF53 chromosome 17 open reading frame 53
CALCR calcitonin receptor
CCDC40 coiled-coil domain containing 40
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CTNS cystinosin, lysosomal cystine transporter
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DES desmin
DGCR8 DGCR8 microprocessor complex subunit
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOCK9 dedicator of cytokinesis 9
DOPEY2 dopey family member 2
EFNB1 ephrin-B1
ELF5 E74-like factor 5 (ets domain transcription factor)
ELN elastin
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM13A family with sequence similarity 13, member A
FGFR1 fibroblast growth factor receptor 1
FRMD1 FERM domain containing 1
FSTL1 follistatin-like 1
GJA4 gap junction protein, alpha 4, 37kDa
GP2 glycoprotein 2 (zymogen granule membrane)
GPR182 G protein-coupled receptor 182
GPR85 G protein-coupled receptor 85
GRIP2 glutamate receptor interacting protein 2
HAO2 hydroxyacid oxidase 2 (long chain)
HAP1 huntingtin-associated protein 1
HFE hemochromatosis
HIST1H2BB histone cluster 1, H2bb
HRH1 histamine receptor H1
HYAL1 hyaluronoglucosaminidase 1
IFNA2 interferon, alpha 2
IMPG2 interphotoreceptor matrix proteoglycan 2
INE1 inactivation escape 1 (non-protein coding)
IQCK IQ motif containing K
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KHSRP KH-type splicing regulatory protein
KIAA1462 KIAA1462
KIF13B kinesin family member 13B
LOC390998 ribosomal protein L10 pseudogene
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MAP2K7 mitogen-activated protein kinase kinase 7
MBNL2 muscleblind-like splicing regulator 2
MMP13 matrix metallopeptidase 13
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC3B mucin 3B, cell surface associated
MVB12B multivesicular body subunit 12B
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NPFFR1 neuropeptide FF receptor 1
NPPA natriuretic peptide A
PCDH1 protocadherin 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PHC3 polyhomeotic homolog 3 (Drosophila)
PHF1 PHD finger protein 1
PKP2 plakophilin 2
PLCB2 phospholipase C, beta 2
PLSCR2 phospholipid scramblase 2
POU5F1B POU class 5 homeobox 1B
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RASL11B RAS-like, family 11, member B
RBP4 retinol binding protein 4, plasma
RGS6 regulator of G-protein signaling 6
RTN1 reticulon 1
SARM1 sterile alpha and TIR motif containing 1
SCARF1 scavenger receptor class F, member 1
SERGEF secretion regulating guanine nucleotide exchange factor
SH3GL3 SH3-domain GRB2-like 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNTG1 syntrophin, gamma 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPTBN2 spectrin, beta, non-erythrocytic 2
STAT2 signal transducer and activator of transcription 2, 113kDa
STS steroid sulfatase (microsomal), isozyme S
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAPBPL TAP binding protein-like
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM3 tripartite motif containing 3
TSKS testis-specific serine kinase substrate
TTC38 tetratricopeptide repeat domain 38
TTLL3 tubulin tyrosine ligase-like family member 3
TUBA3C tubulin, alpha 3c
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WFDC8 WAP four-disulfide core domain 8

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTL8 actin-like 8
AFAP1 actin filament associated protein 1
AMH anti-Mullerian hormone
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARC activity-regulated cytoskeleton-associated protein
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF54 chromosome 1 open reading frame 54
CBR3 carbonyl reductase 3
CBX8 chromobox homolog 8
CCDC121 coiled-coil domain containing 121
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79B CD79b molecule, immunoglobulin-associated beta
CDHR2 cadherin-related family member 2
CDK6 cyclin-dependent kinase 6
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CES3 carboxylesterase 3
CFAP45 cilia and flagella associated protein 45
CPNE7 copine VII
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRY2 cryptochrome circadian clock 2
CSF1R colony stimulating factor 1 receptor
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKQ diacylglycerol kinase, theta 110kDa
DPY19L1P1 DPY19L1 pseudogene 1
EXOC6B exocyst complex component 6B
FAM120C family with sequence similarity 120C
FAM188A family with sequence similarity 188, member A
FGL1 fibrinogen-like 1
FLJ21369 uncharacterized protein FLJ21369
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GATA4 GATA binding protein 4
GPC3 glypican 3
GPR3 G protein-coupled receptor 3
HIST1H3E histone cluster 1, H3e
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSF1 heat shock transcription factor 1
HYAL3 hyaluronoglucosaminidase 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RA interleukin 17 receptor A
IL2 interleukin 2
INPP5J inositol polyphosphate-5-phosphatase J
IRF9 interferon regulatory factor 9
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0754 KIAA0754
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMP3 lysosomal-associated membrane protein 3
LOC729164 hCG1732469
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MEGF6 multiple EGF-like-domains 6
MSI1 musashi RNA-binding protein 1
MUC6 mucin 6, oligomeric mucus/gel-forming
MX2 MX dynamin-like GTPase 2
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NEUROD4 neuronal differentiation 4
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NPY4R neuropeptide Y receptor Y4
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE8B phosphodiesterase 8B
PICK1 protein interacting with PRKCA 1
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
PRAMEF11 PRAME family member 11
PRKCE protein kinase C, epsilon
QSER1 glutamine and serine rich 1
RAB40C RAB40C, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS20 regulator of G-protein signaling 20
RNF39 ring finger protein 39
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RORC RAR-related orphan receptor C
RPH3A rabphilin 3A
RPL13P5 ribosomal protein L13 pseudogene 5
RUSC2 RUN and SH3 domain containing 2
SCN1B sodium channel, voltage gated, type I beta subunit
SLC22A14 solute carrier family 22, member 14
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
TPSG1 tryptase gamma 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM21 tripartite motif containing 21
TWISTNB TWIST neighbor
UNC93B1 unc-93 homolog B1 (C. elegans)
VLDLR very low density lipoprotein receptor
ZNF137P zinc finger protein 137, pseudogene
ZNF324 zinc finger protein 324
ZNF532 zinc finger protein 532
ZNF750 zinc finger protein 750
ZNF804A zinc finger protein 804A
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1