etidronic acid-3325 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the etidronic acid-3325 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRE1 adhesion G protein-coupled receptor E1
ADRA1A adrenoceptor alpha 1A
AHNAK2 AHNAK nucleoprotein 2
APOH apolipoprotein H (beta-2-glycoprotein I)
ARR3 arrestin 3, retinal (X-arrestin)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BGN biglycan
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD1A CD1a molecule
CDC42 cell division cycle 42
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEP112 centrosomal protein 112kDa
CNOT2 CCR4-NOT transcription complex, subunit 2
CNR2 cannabinoid receptor 2 (macrophage)
COL3A1 collagen, type III, alpha 1
CYB5A cytochrome b5 type A (microsomal)
DOK4 docking protein 4
DPYS dihydropyrimidinase
EPHA3 EPH receptor A3
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
FLJ42627 uncharacterized LOC645644
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GRM1 glutamate receptor, metabotropic 1
GRPR gastrin-releasing peptide receptor
HOXA2 homeobox A2
HOXC4 homeobox C4
HPCAL4 hippocalcin like 4
ICA1 islet cell autoantigen 1, 69kDa
IL11 interleukin 11
IL1B interleukin 1, beta
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
LENEP lens epithelial protein
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL2 lysyl oxidase-like 2
LRP12 low density lipoprotein receptor-related protein 12
LRRTM2 leucine rich repeat transmembrane neuronal 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MST1 macrophage stimulating 1
MTAP methylthioadenosine phosphorylase
MUC3B mucin 3B, cell surface associated
MYBPC3 myosin binding protein C, cardiac
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYF5 myogenic factor 5
NAG18 NAG18 mRNA
NEK1 NIMA-related kinase 1
NEUROD1 neuronal differentiation 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NYNRIN NYN domain and retroviral integrase containing
OMG oligodendrocyte myelin glycoprotein
OR1E1 olfactory receptor, family 1, subfamily E, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTOR otoraplin
OXCT2 3-oxoacid CoA transferase 2
PCDHGA3 protocadherin gamma subfamily A, 3
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDM16 PR domain containing 16
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RNF186 ring finger protein 186
SAFB2 scaffold attachment factor B2
SAMD9 sterile alpha motif domain containing 9
SFTPB surfactant protein B
SH2D3A SH2 domain containing 3A
SIGLEC7 sialic acid binding Ig-like lectin 7
SIRT5 sirtuin 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC35E2 solute carrier family 35, member E2
SLC43A3 solute carrier family 43, member 3
SNCAIP synuclein, alpha interacting protein
SNX29P2 sorting nexin 29 pseudogene 2
SPRR2B small proline-rich protein 2B
STRN3 striatin, calmodulin binding protein 3
STYK1 serine/threonine/tyrosine kinase 1
TAT tyrosine aminotransferase
TEX15 testis expressed 15
TIMP3 TIMP metallopeptidase inhibitor 3
TJAP1 tight junction associated protein 1 (peripheral)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPMT thiopurine S-methyltransferase
TRIL TLR4 interactor with leucine-rich repeats
TRIM29 tripartite motif containing 29
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WAPAL wings apart-like homolog (Drosophila)
YPEL1 yippee-like 1 (Drosophila)
ZMAT4 zinc finger, matrin-type 4
ZNF287 zinc finger protein 287
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADGRE5 adhesion G protein-coupled receptor E5
AKIP1 A kinase (PRKA) interacting protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
C4ORF29 chromosome 4 open reading frame 29
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMTA1 calmodulin binding transcription activator 1
CAPN15 calpain 15
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CENPJ centromere protein J
CEP97 centrosomal protein 97kDa
CGREF1 cell growth regulator with EF-hand domain 1
CIDEB cell death-inducing DFFA-like effector b
CLDN15 claudin 15
COPZ2 coatomer protein complex, subunit zeta 2
CORO7 coronin 7
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DDIT3 DNA-damage-inducible transcript 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EGR3 early growth response 3
ETNK2 ethanolamine kinase 2
FAM46C family with sequence similarity 46, member C
FBRS fibrosin
FLCN folliculin
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMIP GEM interacting protein
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
HIST1H2AL histone cluster 1, H2al
HIST1H4F histone cluster 1, H4f
HOXA4 homeobox A4
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCTD7 potassium channel tetramerization domain containing 7
KIAA0125 KIAA0125
LAMB3 laminin, beta 3
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MMP2 matrix metallopeptidase 2
MSMB microseminoprotein, beta-
MYO9A myosin IXA
NPFFR1 neuropeptide FF receptor 1
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARD6A par-6 family cell polarity regulator alpha
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QPCTL glutaminyl-peptide cyclotransferase-like
RAB30 RAB30, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAI14 retinoic acid induced 14
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB1 Rho-related BTB domain containing 1
RPGRIP1L RPGRIP1-like
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT2 sirtuin 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNORA21 small nucleolar RNA, H/ACA box 21
SPINK4 serine peptidase inhibitor, Kazal type 4
STARD13 StAR-related lipid transfer (START) domain containing 13
STC2 stanniocalcin 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TDRD1 tudor domain containing 1
TH tyrosine hydroxylase
TMPRSS3 transmembrane protease, serine 3
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSKU tsukushi, small leucine rich proteoglycan
UNC119 unc-119 homolog (C. elegans)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZFHX3 zinc finger homeobox 3
ZNF134 zinc finger protein 134
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721