ethosuximide-2116 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ethosuximide-2116 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDOB aldolase B, fructose-bisphosphate
ANXA10 annexin A10
ARHGAP33 Rho GTPase activating protein 33
ARSB arylsulfatase B
AURKA aurora kinase A
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BTBD7 BTB (POZ) domain containing 7
C11ORF30 chromosome 11 open reading frame 30
C17ORF80 chromosome 17 open reading frame 80
C1QL1 complement component 1, q subcomponent-like 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CACYBP calcyclin binding protein
CALD1 caldesmon 1
CFAP45 cilia and flagella associated protein 45
CFAP69 cilia and flagella associated protein 69
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL9A2 collagen, type IX, alpha 2
CREB5 cAMP responsive element binding protein 5
CREBZF CREB/ATF bZIP transcription factor
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHODH dihydroorotate dehydrogenase (quinone)
DNAAF1 dynein, axonemal, assembly factor 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAL4 dynein, axonemal, light chain 4
DPF3 D4, zinc and double PHD fingers, family 3
EGFL7 EGF-like-domain, multiple 7
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ERO1LB ERO1-like beta (S. cerevisiae)
ETV1 ets variant 1
EXOC7 exocyst complex component 7
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM174B family with sequence similarity 174, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FNDC4 fibronectin type III domain containing 4
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GBP2 guanylate binding protein 2, interferon-inducible
GLB1L galactosidase, beta 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H3G histone cluster 1, H3g
HOOK1 hook microtubule-tethering protein 1
HR hair growth associated
IGHMBP2 immunoglobulin mu binding protein 2
IGL immunoglobulin lambda locus
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
KDM6B lysine (K)-specific demethylase 6B
LDB1 LIM domain binding 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRP1 low density lipoprotein receptor-related protein 1
LRRC37A3 leucine rich repeat containing 37, member A3
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCF2L MCF.2 cell line derived transforming sequence-like
MEF2D myocyte enhancer factor 2D
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTSS1L metastasis suppressor 1-like
MVD mevalonate (diphospho) decarboxylase
NOP16 NOP16 nucleolar protein
NPR1 natriuretic peptide receptor 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTF3 neurotrophin 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PDGFA platelet-derived growth factor alpha polypeptide
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
RAB36 RAB36, member RAS oncogene family
REST RE1-silencing transcription factor
RIN3 Ras and Rab interactor 3
RNF122 ring finger protein 122
RPL23AP32 ribosomal protein L23a pseudogene 32
RWDD2A RWD domain containing 2A
SC5D sterol-C5-desaturase
SIRT6 sirtuin 6
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SRD5A3 steroid 5 alpha-reductase 3
SSX1 synovial sarcoma, X breakpoint 1
SUGP1 SURP and G patch domain containing 1
TEX14 testis expressed 14
TLE2 transducin-like enhancer of split 2
TRIM29 tripartite motif containing 29
TTC9 tetratricopeptide repeat domain 9
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
YTHDC1 YTH domain containing 1
ZFP30 ZFP30 zinc finger protein
ZNF423 zinc finger protein 423
ZNF442 zinc finger protein 442
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARRB2 arrestin, beta 2
ASTE1 asteroid homolog 1 (Drosophila)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCAS4 breast carcinoma amplified sequence 4
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1ORF112 chromosome 1 open reading frame 112
C1ORF159 chromosome 1 open reading frame 159
CCDC176 coiled-coil domain containing 176
CCDC85C coiled-coil domain containing 85C
CD70 CD70 molecule
CDKN2AIP CDKN2A interacting protein
CEP112 centrosomal protein 112kDa
CEP131 centrosomal protein 131kDa
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
DBR1 debranching RNA lariats 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
EFNA3 ephrin-A3
ELP4 elongator acetyltransferase complex subunit 4
ERAP2 endoplasmic reticulum aminopeptidase 2
ERF Ets2 repressor factor
EVPL envoplakin
EXOSC5 exosome component 5
FGGY FGGY carbohydrate kinase domain containing
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP10 FK506 binding protein 10, 65 kDa
FSD1 fibronectin type III and SPRY domain containing 1
GJC1 gap junction protein, gamma 1, 45kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR39 G protein-coupled receptor 39
HP1BP3 heterochromatin protein 1, binding protein 3
HYI hydroxypyruvate isomerase (putative)
IL17RA interleukin 17 receptor A
INF2 inverted formin, FH2 and WH2 domain containing
IREB2 iron-responsive element binding protein 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD20 potassium channel tetramerization domain containing 20
LRRC61 leucine rich repeat containing 61
MCMBP minichromosome maintenance complex binding protein
MON1B MON1 secretory trafficking family member B
MRPL17 mitochondrial ribosomal protein L17
MSL2 male-specific lethal 2 homolog (Drosophila)
NDRG4 NDRG family member 4
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NECAP2 NECAP endocytosis associated 2
NID2 nidogen 2 (osteonidogen)
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OSMR oncostatin M receptor
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEX13 peroxisomal biogenesis factor 13
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PRR15L proline rich 15-like
PRRC1 proline-rich coiled-coil 1
PSAT1 phosphoserine aminotransferase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RANBP17 RAN binding protein 17
RIC8B RIC8 guanine nucleotide exchange factor B
RNF146 ring finger protein 146
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SAMD9 sterile alpha motif domain containing 9
SDCCAG3 serologically defined colon cancer antigen 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A40 solute carrier family 25, member 40
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC41A3 solute carrier family 41, member 3
SMG9 SMG9 nonsense mediated mRNA decay factor
SNX10 sorting nexin 10
ST5 suppression of tumorigenicity 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYNE2 spectrin repeat containing, nuclear envelope 2
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
THOC1 THO complex 1
TLN1 talin 1
TRIM52 tripartite motif containing 52
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UBN1 ubinuclein 1
UBQLN4 ubiquilin 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB3 zinc finger and BTB domain containing 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF134 zinc finger protein 134
ZNF254 zinc finger protein 254
ZNF34 zinc finger protein 34
ZNF767P zinc finger family member 767, pseudogene
ZSCAN5A zinc finger and SCAN domain containing 5A