ethisterone-2366 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the ethisterone-2366 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANK1 ankyrin 1, erythrocytic
APOE apolipoprotein E
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CAPRIN2 caprin family member 2
CDR2L cerebellar degeneration-related protein 2-like
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CST1 cystatin SN
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
ERAP1 endoplasmic reticulum aminopeptidase 1
FGF17 fibroblast growth factor 17
FLOT2 flotillin 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GIF gastric intrinsic factor (vitamin B synthesis)
GOSR2 golgi SNAP receptor complex member 2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIP2 glutamate receptor interacting protein 2
GSTA3 glutathione S-transferase alpha 3
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HPR haptoglobin-related protein
HSPB6 heat shock protein, alpha-crystallin-related, B6
HSPG2 heparan sulfate proteoglycan 2
IL1R1 interleukin 1 receptor, type I
JRK Jrk homolog (mouse)
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KDM4C lysine (K)-specific demethylase 4C
KIAA1109 KIAA1109
KIF1A kinesin family member 1A
LATS1 large tumor suppressor kinase 1
LOC100131532 uncharacterized LOC100131532
LPAR4 lysophosphatidic acid receptor 4
MAX MYC associated factor X
MRAS muscle RAS oncogene homolog
MTSS1L metastasis suppressor 1-like
MVK mevalonate kinase
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NF1 neurofibromin 1
NNAT neuronatin
NPEPL1 aminopeptidase-like 1
NPM3 nucleophosmin/nucleoplasmin 3
OR7A10 olfactory receptor, family 7, subfamily A, member 10
PCDHGA11 protocadherin gamma subfamily A, 11
PCNX pecanex homolog (Drosophila)
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX5 peroxisomal biogenesis factor 5
PHF20L1 PHD finger protein 20-like 1
PHF3 PHD finger protein 3
PIAS3 protein inhibitor of activated STAT, 3
PLK4 polo-like kinase 4
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PYGB phosphorylase, glycogen; brain
RABGAP1L RAB GTPase activating protein 1-like
RAD50 RAD50 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SC5D sterol-C5-desaturase
SCRG1 stimulator of chondrogenesis 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIDT2 SID1 transmembrane family, member 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A8 solute carrier family 12, member 8
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SRSF7 serine/arginine-rich splicing factor 7
SSX1 synovial sarcoma, X breakpoint 1
STS steroid sulfatase (microsomal), isozyme S
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBX10 T-box 10
TFR2 transferrin receptor 2
TLX2 T-cell leukemia homeobox 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNK1 tyrosine kinase, non-receptor, 1
TPM1 tropomyosin 1 (alpha)
TRIB2 tribbles pseudokinase 2
TRIM48 tripartite motif containing 48
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XDH xanthine dehydrogenase
ZBTB22 zinc finger and BTB domain containing 22
ZFX zinc finger protein, X-linked
ZNF337 zinc finger protein 337
ZNF43 zinc finger protein 43
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM23 ADAM metallopeptidase domain 23
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANP32A-IT1 ANP32A intronic transcript 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG9A autophagy related 9A
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
C4ORF29 chromosome 4 open reading frame 29
C6ORF47 chromosome 6 open reading frame 47
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK3 cyclin-dependent kinase 3
CEP70 centrosomal protein 70kDa
CNN2 calponin 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDIT3 DNA-damage-inducible transcript 3
EFHC1 EF-hand domain (C-terminal) containing 1
ELP6 elongator acetyltransferase complex subunit 6
FAM134B family with sequence similarity 134, member B
FBXW12 F-box and WD repeat domain containing 12
FHL3 four and a half LIM domains 3
FJX1 four jointed box 1 (Drosophila)
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMEB1 glucocorticoid modulatory element binding protein 1
GRAMD1B GRAM domain containing 1B
GUSBP3 glucuronidase, beta pseudogene 3
HOOK2 hook microtubule-tethering protein 2
IFT46 intraflagellar transport 46
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KATNBL1 katanin p80 subunit B-like 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0894 KIAA0894 protein
KLHDC4 kelch domain containing 4
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC42 leucine rich repeat containing 42
MAPK3 mitogen-activated protein kinase 3
MED15 mediator complex subunit 15
MRPL52 mitochondrial ribosomal protein L52
NIPAL2 NIPA-like domain containing 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PCYOX1 prenylcysteine oxidase 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PMCH pro-melanin-concentrating hormone
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RHOC ras homolog family member C
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RUFY2 RUN and FYVE domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCD5 stearoyl-CoA desaturase 5
SERINC5 serine incorporator 5
SH2B2 SH2B adaptor protein 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMR3A submaxillary gland androgen regulated protein 3A
SND1-IT1 SND1 intronic transcript 1
SNIP1 Smad nuclear interacting protein 1
SPATA2L spermatogenesis associated 2-like
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SURF2 surfeit 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNJ2BP synaptojanin 2 binding protein
TBCCD1 TBCC domain containing 1
TGM5 transglutaminase 5
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TOR4A torsin family 4, member A
TRAC T cell receptor alpha constant
TRIM22 tripartite motif containing 22
TSPAN13 tetraspanin 13
TTC4 tetratricopeptide repeat domain 4
UBQLN4 ubiquilin 4
UEVLD UEV and lactate/malate dehyrogenase domains
VASP vasodilator-stimulated phosphoprotein
WDR62 WD repeat domain 62
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZHX2 zinc fingers and homeoboxes 2
ZNF160 zinc finger protein 160
ZNF197 zinc finger protein 197
ZNF324 zinc finger protein 324
ZNF426 zinc finger protein 426
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721