ethisterone-2326 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the ethisterone-2326 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
AIM2 absent in melanoma 2
ANGPTL2 angiopoietin-like 2
APC adenomatous polyposis coli
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARC activity-regulated cytoskeleton-associated protein
ASB1 ankyrin repeat and SOCS box containing 1
ATG10 autophagy related 10
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BTN3A1 butyrophilin, subfamily 3, member A1
C2ORF27A chromosome 2 open reading frame 27A
CADM3 cell adhesion molecule 3
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCL19 chemokine (C-C motif) ligand 19
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD8A CD8a molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLCA1 chloride channel accessory 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DRD1 dopamine receptor D1
EPOR erythropoietin receptor
EPS8L3 EPS8-like 3
ERP44 endoplasmic reticulum protein 44
FADS2 fatty acid desaturase 2
FAM155A family with sequence similarity 155, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FCMR Fc fragment of IgM receptor
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GLI2 GLI family zinc finger 2
GMPR guanosine monophosphate reductase
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR182 G protein-coupled receptor 182
GSTTP1 glutathione S-transferase theta pseudogene 1
HIST1H2BL histone cluster 1, H2bl
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IHH indian hedgehog
IL2RB interleukin 2 receptor, beta
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
JAK3 Janus kinase 3
KLK8 kallikrein-related peptidase 8
KREMEN2 kringle containing transmembrane protein 2
KRT83 keratin 83, type II
LIMCH1 LIM and calponin homology domains 1
LINC00216 long intergenic non-protein coding RNA 216
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MMP25 matrix metallopeptidase 25
NME5 NME/NM23 family member 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRF1 nuclear respiratory factor 1
NUP54 nucleoporin 54kDa
OCA2 oculocutaneous albinism II
OLFML2B olfactomedin-like 2B
PLCD1 phospholipase C, delta 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLTP phospholipid transfer protein
PRLR prolactin receptor
PRPH2 peripherin 2 (retinal degeneration, slow)
PSG6 pregnancy specific beta-1-glycoprotein 6
PTAFR platelet-activating factor receptor
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBFA ribosome binding factor A (putative)
RPS3A ribosomal protein S3A
SARM1 sterile alpha and TIR motif containing 1
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SH2D2A SH2 domain containing 2A
SIRT4 sirtuin 4
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SMR3A submaxillary gland androgen regulated protein 3A
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRCAP Snf2-related CREBBP activator protein
SRRT serrate, RNA effector molecule
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STK17A serine/threonine kinase 17a
T T, brachyury homolog (mouse)
TBL1Y transducin (beta)-like 1, Y-linked
TBX6 T-box 6
TFR2 transferrin receptor 2
TM4SF5 transmembrane 4 L six family member 5
TRIM29 tripartite motif containing 29
VIL1 villin 1
VIPR1 vasoactive intestinal peptide receptor 1
WDR62 WD repeat domain 62
ZC3H7B zinc finger CCCH-type containing 7B
ZFP64 ZFP64 zinc finger protein
ZNF286A zinc finger protein 286A
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
AGBL2 ATP/GTP binding protein-like 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGAP5 Rho GTPase activating protein 5
AUTS2 autism susceptibility candidate 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCORL1 BCL6 corepressor-like 1
C17ORF80 chromosome 17 open reading frame 80
CBX8 chromobox homolog 8
CD79B CD79b molecule, immunoglobulin-associated beta
CDADC1 cytidine and dCMP deaminase domain containing 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORO7 coronin 7
CORT cortistatin
CRMP1 collapsin response mediator protein 1
CSF1R colony stimulating factor 1 receptor
CTSF cathepsin F
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EMID1 EMI domain containing 1
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM110B family with sequence similarity 110, member B
FAM214B family with sequence similarity 214, member B
FBXL2 F-box and leucine-rich repeat protein 2
FBXO2 F-box protein 2
FRMPD1 FERM and PDZ domain containing 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GIF gastric intrinsic factor (vitamin B synthesis)
GPR176 G protein-coupled receptor 176
GPR85 G protein-coupled receptor 85
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRM6 glutamate receptor, metabotropic 6
GSTT1 glutathione S-transferase theta 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HP1BP3 heterochromatin protein 1, binding protein 3
HPX hemopexin
IFT140 intraflagellar transport 140
IL2 interleukin 2
IL36A interleukin 36, alpha
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KEL Kell blood group, metallo-endopeptidase
KIAA0319L KIAA0319-like
KIAA0754 KIAA0754
KLHL25 kelch-like family member 25
KLK15 kallikrein-related peptidase 15
LHX1 LIM homeobox 1
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LTC4S leukotriene C4 synthase
MIP major intrinsic protein of lens fiber
MRPL41 mitochondrial ribosomal protein L41
MTA2 metastasis associated 1 family, member 2
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NT5M 5',3'-nucleotidase, mitochondrial
ONECUT1 one cut homeobox 1
ONECUT2 one cut homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OVOL1 ovo-like zinc finger 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGBD5 piggyBac transposable element derived 5
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLL polymerase (DNA directed), lambda
PRDM16 PR domain containing 16
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTK6 protein tyrosine kinase 6
RAB33A RAB33A, member RAS oncogene family
RNF39 ring finger protein 39
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL10L ribosomal protein L10-like
SCN10A sodium channel, voltage gated, type X alpha subunit
SECTM1 secreted and transmembrane 1
SIPA1 signal-induced proliferation-associated 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMA4 glucuronidase, beta pseudogene
SPEF1 sperm flagellar 1
STARD8 StAR-related lipid transfer (START) domain containing 8
SULT4A1 sulfotransferase family 4A, member 1
TARP TCR gamma alternate reading frame protein
TBKBP1 TBK1 binding protein 1
VIM vimentin
YPEL1 yippee-like 1 (Drosophila)
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF10 zinc finger protein 10
ZSWIM1 zinc finger, SWIM-type containing 1