ethionamide-4418 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ethionamide-4418 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ANG angiogenin, ribonuclease, RNase A family, 5
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APAF1 apoptotic peptidase activating factor 1
ARTN artemin
ASIC1 acid sensing (proton gated) ion channel 1
BNC2 basonuclin 2
CALB2 calbindin 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD1A CD1a molecule
CD52 CD52 molecule
CFAP69 cilia and flagella associated protein 69
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLTA clathrin, light chain A
CRHR2 corticotropin releasing hormone receptor 2
CYBB cytochrome b-245, beta polypeptide
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DEPDC5 DEP domain containing 5
DFNB31 deafness, autosomal recessive 31
DGCR14 DiGeorge syndrome critical region gene 14
DPF1 D4, zinc and double PHD fingers family 1
ECE1 endothelin converting enzyme 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EMCN endomucin
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FBN1 fibrillin 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FRMD1 FERM domain containing 1
FYB FYN binding protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GM2A GM2 ganglioside activator
GP2 glycoprotein 2 (zymogen granule membrane)
GRIP2 glutamate receptor interacting protein 2
GRPR gastrin-releasing peptide receptor
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIC2 hypermethylated in cancer 2
HLA-DMB major histocompatibility complex, class II, DM beta
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXB5 homeobox B5
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IBSP integrin-binding sialoprotein
IGFBP5 insulin-like growth factor binding protein 5
IGLJ3 immunoglobulin lambda joining 3
IL1RAP interleukin 1 receptor accessory protein
ITM2C integral membrane protein 2C
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA1109 KIAA1109
KIF25 kinesin family member 25
LOC390998 ribosomal protein L10 pseudogene
MCAM melanoma cell adhesion molecule
MIER2 mesoderm induction early response 1, family member 2
MR1 major histocompatibility complex, class I-related
MT3 metallothionein 3
MVB12B multivesicular body subunit 12B
MYLK myosin light chain kinase
NCF4 neutrophil cytosolic factor 4, 40kDa
NEIL1 nei endonuclease VIII-like 1 (E. coli)
PAPOLG poly(A) polymerase gamma
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGA8 protocadherin gamma subfamily A, 8
PPARD peroxisome proliferator-activated receptor delta
RNF17 ring finger protein 17
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
SECTM1 secreted and transmembrane 1
SIM2 single-minded family bHLH transcription factor 2
SIRT4 sirtuin 4
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS7 suppressor of cytokine signaling 7
SOWAHC sosondowah ankyrin repeat domain family member C
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STAB2 stabilin 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYN3 synapsin III
TAOK2 TAO kinase 2
TM4SF5 transmembrane 4 L six family member 5
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNPO2 transportin 2
TP53I11 tumor protein p53 inducible protein 11
TSSK2 testis-specific serine kinase 2
TTC39A tetratricopeptide repeat domain 39A
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UMPS uridine monophosphate synthetase
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WDR55 WD repeat domain 55
WDR59 WD repeat domain 59
WNT16 wingless-type MMTV integration site family, member 16
XYLB xylulokinase homolog (H. influenzae)
ZFP64 ZFP64 zinc finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ART1 ADP-ribosyltransferase 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP15 bone morphogenetic protein 15
BST2 bone marrow stromal cell antigen 2
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CARF calcium responsive transcription factor
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CDK20 cyclin-dependent kinase 20
CNR2 cannabinoid receptor 2 (macrophage)
CNTFR ciliary neurotrophic factor receptor
CNTNAP1 contactin associated protein 1
CPNE7 copine VII
CRIP1 cysteine-rich protein 1 (intestinal)
CUL9 cullin 9
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKQ diacylglycerol kinase, theta 110kDa
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EGFL7 EGF-like-domain, multiple 7
ERCC6 excision repair cross-complementation group 6
ETV6 ets variant 6
F2R coagulation factor II (thrombin) receptor
FBXL2 F-box and leucine-rich repeat protein 2
FGF13 fibroblast growth factor 13
FRMD8 FERM domain containing 8
GAS2 growth arrest-specific 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR27 G protein-coupled receptor 27
GPR3 G protein-coupled receptor 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTTP1 glutathione S-transferase theta pseudogene 1
HIRA histone cell cycle regulator
HYAL3 hyaluronoglucosaminidase 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP6 insulin-like growth factor binding protein 6
IRF9 interferon regulatory factor 9
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LGALS4 lectin, galactoside-binding, soluble, 4
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL3 lysyl oxidase-like 3
MED15 mediator complex subunit 15
MEGF8 multiple EGF-like-domains 8
MRPL41 mitochondrial ribosomal protein L41
N4BP3 NEDD4 binding protein 3
NKX2-5 NK2 homeobox 5
NPFFR1 neuropeptide FF receptor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZD2 PDZ domain containing 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
POLL polymerase (DNA directed), lambda
PRR14L proline rich 14-like
QPCT glutaminyl-peptide cyclotransferase
RAB40C RAB40C, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHBDD3 rhomboid domain containing 3
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RUSC2 RUN and SH3 domain containing 2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SH3D21 SH3 domain containing 21
SKI SKI proto-oncogene
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR2B small proline-rich protein 2B
STRA6 stimulated by retinoic acid 6
SYNC syncoilin, intermediate filament protein
TAOK1 TAO kinase 1
TARP TCR gamma alternate reading frame protein
TBC1D2 TBC1 domain family, member 2
TBL1Y transducin (beta)-like 1, Y-linked
THRB thyroid hormone receptor, beta
TPSG1 tryptase gamma 1
TRIM5 tripartite motif containing 5
WFDC2 WAP four-disulfide core domain 2
ZNF230 zinc finger protein 230
ZNF552 zinc finger protein 552
ZNF750 zinc finger protein 750