ethambutol-4001 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ethambutol-4001 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AAK1 AP2 associated kinase 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACSM3 acyl-CoA synthetase medium-chain family member 3
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANGPT4 angiopoietin 4
ANKLE2 ankyrin repeat and LEM domain containing 2
ARHGAP6 Rho GTPase activating protein 6
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
C10ORF12 chromosome 10 open reading frame 12
C22ORF29 chromosome 22 open reading frame 29
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCDC28B coiled-coil domain containing 28B
CDY1 chromodomain protein, Y-linked, 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFHR2 complement factor H-related 2
CRISP2 cysteine-rich secretory protein 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
DENND2A DENN/MADD domain containing 2A
DHODH dihydroorotate dehydrogenase (quinone)
DIO3 deiodinase, iodothyronine, type III
DMP1 dentin matrix acidic phosphoprotein 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EML3 echinoderm microtubule associated protein like 3
EVI2B ecotropic viral integration site 2B
FAM134B family with sequence similarity 134, member B
FBXO40 F-box protein 40
FMO5 flavin containing monooxygenase 5
FN1 fibronectin 1
FOXO4 forkhead box O4
GAB1 GRB2-associated binding protein 1
GHRHR growth hormone releasing hormone receptor
GLP1R glucagon-like peptide 1 receptor
GPR135 G protein-coupled receptor 135
HAP1 huntingtin-associated protein 1
HIST1H4A histone cluster 1, H4a
HIST1H4D histone cluster 1, H4d
HOXB6 homeobox B6
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIFC3 kinesin family member C3
KLK12 kallikrein-related peptidase 12
LDB1 LIM domain binding 1
LDB2 LIM domain binding 2
LIMD1 LIM domains containing 1
LINC00302 long intergenic non-protein coding RNA 302
LINC00652 long intergenic non-protein coding RNA 652
LPP LIM domain containing preferred translocation partner in lipoma
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPZ myelin protein zero
MRPL41 mitochondrial ribosomal protein L41
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
OTUD7B OTU deubiquitinase 7B
PCDH1 protocadherin 1
PDE10A phosphodiesterase 10A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PHEX phosphate regulating endopeptidase homolog, X-linked
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PRAMEF11 PRAME family member 11
PRKCE protein kinase C, epsilon
PRKCI protein kinase C, iota
PRTN3 proteinase 3
PTBP3 polypyrimidine tract binding protein 3
PTK2B protein tyrosine kinase 2 beta
RARB retinoic acid receptor, beta
RGS12 regulator of G-protein signaling 12
RHOBTB3 Rho-related BTB domain containing 3
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SPIDR scaffolding protein involved in DNA repair
SPTAN1 spectrin, alpha, non-erythrocytic 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK17A serine/threonine kinase 17a
STS steroid sulfatase (microsomal), isozyme S
TBL1Y transducin (beta)-like 1, Y-linked
TCEAL2 transcription elongation factor A (SII)-like 2
THBS3 thrombospondin 3
THSD4 thrombospondin, type I, domain containing 4
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNK2 tyrosine kinase, non-receptor, 2
TNNT3 troponin T type 3 (skeletal, fast)
TRIM15 tripartite motif containing 15
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TTC30A tetratricopeptide repeat domain 30A
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UHRF1BP1L UHRF1 binding protein 1-like
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAX2 ventral anterior homeobox 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF24 zinc finger protein 24
ZNF334 zinc finger protein 334
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ALG12 ALG12, alpha-1,6-mannosyltransferase
APOC4 apolipoprotein C-IV
ARC activity-regulated cytoskeleton-associated protein
ARHGAP24 Rho GTPase activating protein 24
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARRB2 arrestin, beta 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B9D2 B9 protein domain 2
BMP15 bone morphogenetic protein 15
CA9 carbonic anhydrase IX
CCNJL cyclin J-like
CEL carboxyl ester lipase
CINP cyclin-dependent kinase 2 interacting protein
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGB3 cyclic nucleotide gated channel beta 3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CUZD1 CUB and zona pellucida-like domains 1
CYB5R2 cytochrome b5 reductase 2
DBF4B DBF4 zinc finger B
DEAF1 DEAF1 transcription factor
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAL4 dynein, axonemal, light chain 4
DOCK1 dedicator of cytokinesis 1
EFNB1 ephrin-B1
EVPL envoplakin
FA2H fatty acid 2-hydroxylase
FBXL7 F-box and leucine-rich repeat protein 7
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA9 gap junction protein, alpha 9, 59kDa
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRM4 glutamate receptor, metabotropic 4
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HOXC10 homeobox C10
HOXC13 homeobox C13
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL12RB1 interleukin 12 receptor, beta 1
KDM8 lysine (K)-specific demethylase 8
KIAA1644 KIAA1644
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MN1 meningioma (disrupted in balanced translocation) 1
MXRA8 matrix-remodelling associated 8
NAG18 NAG18 mRNA
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NINJ1 ninjurin 1
NIPAL2 NIPA-like domain containing 2
NUBP2 nucleotide binding protein 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PEX26 peroxisomal biogenesis factor 26
PLA2G15 phospholipase A2, group XV
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLXNB3 plexin B3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLL polymerase (DNA directed), lambda
PRR4 proline rich 4 (lacrimal)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGCC regulator of cell cycle
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RIN1 Ras and Rab interactor 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUSC2 RUN and SH3 domain containing 2
SCARA3 scavenger receptor class A, member 3
SCUBE3 signal peptide, CUB domain, EGF-like 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLAMF7 SLAM family member 7
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SSTR4 somatostatin receptor 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D17 TBC1 domain family, member 17
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TESPA1 thymocyte expressed, positive selection associated 1
TMEM212 transmembrane protein 212
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSNAXIP1 translin-associated factor X interacting protein 1
TXK TXK tyrosine kinase
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
WFDC2 WAP four-disulfide core domain 2
WNT1 wingless-type MMTV integration site family, member 1
ZFHX3 zinc finger homeobox 3
ZNF10 zinc finger protein 10
ZNF37BP zinc finger protein 37B, pseudogene
ZNF510 zinc finger protein 510
ZNF529 zinc finger protein 529