etacrynic acid-5742 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the etacrynic acid-5742 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ADAM20 ADAM metallopeptidase domain 20
ADH6 alcohol dehydrogenase 6 (class V)
ADORA1 adenosine A1 receptor
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APOA4 apolipoprotein A-IV
ARHGAP28 Rho GTPase activating protein 28
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BGN biglycan
BTBD18 BTB (POZ) domain containing 18
BTN3A2 butyrophilin, subfamily 3, member A2
C14ORF79 chromosome 14 open reading frame 79
C22ORF46 chromosome 22 open reading frame 46
CALCB calcitonin-related polypeptide beta
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC81 coiled-coil domain containing 81
CD40LG CD40 ligand
CDK12 cyclin-dependent kinase 12
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COMT catechol-O-methyltransferase
CREB3L1 cAMP responsive element binding protein 3-like 1
CYBB cytochrome b-245, beta polypeptide
DNAAF1 dynein, axonemal, assembly factor 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EDA ectodysplasin A
ELAC2 elaC ribonuclease Z 2
ELOVL5 ELOVL fatty acid elongase 5
EMID1 EMI domain containing 1
ENG endoglin
EPYC epiphycan
FAM212B family with sequence similarity 212, member B
FGF18 fibroblast growth factor 18
FRMD1 FERM domain containing 1
GHRHR growth hormone releasing hormone receptor
GSK3A glycogen synthase kinase 3 alpha
GSTM5 glutathione S-transferase mu 5
HBS1L HBS1-like translational GTPase
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXD11 homeobox D11
HPN hepsin
HRH2 histamine receptor H2
HSPG2 heparan sulfate proteoglycan 2
IGHD immunoglobulin heavy constant delta
ING4 inhibitor of growth family, member 4
INO80D INO80 complex subunit D
ITGA7 integrin, alpha 7
ITGA8 integrin, alpha 8
KCTD14 potassium channel tetramerization domain containing 14
KDR kinase insert domain receptor
KIAA0087 KIAA0087
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRP1 low density lipoprotein receptor-related protein 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MCF2L MCF.2 cell line derived transforming sequence-like
MCOLN3 mucolipin 3
METTL16 methyltransferase like 16
MMP7 matrix metallopeptidase 7
MTMR8 myotubularin related protein 8
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDNF neuron-derived neurotrophic factor
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPPA natriuretic peptide A
NRCAM neuronal cell adhesion molecule
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM1 olfactomedin 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PASK PAS domain containing serine/threonine kinase
PAX8 paired box 8
PDCD2 programmed cell death 2
PDE10A phosphodiesterase 10A
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PODNL1 podocan-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD51B RAD51 paralog B
RXRB retinoid X receptor, beta
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMAD7 SMAD family member 7
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SSX1 synovial sarcoma, X breakpoint 1
TBKBP1 TBK1 binding protein 1
TM4SF5 transmembrane 4 L six family member 5
TMEM19 transmembrane protein 19
TMEM212 transmembrane protein 212
TPSAB1 tryptase alpha/beta 1
TSSK2 testis-specific serine kinase 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WNT3 wingless-type MMTV integration site family, member 3

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACVR2B activin A receptor, type IIB
ADAM15 ADAM metallopeptidase domain 15
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AUH AU RNA binding protein/enoyl-CoA hydratase
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAG4 BCL2-associated athanogene 4
BCL2L2 BCL2-like 2
BOLA1 bolA family member 1
C1ORF56 chromosome 1 open reading frame 56
C1R complement component 1, r subcomponent
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC88C coiled-coil domain containing 88C
CCDC9 coiled-coil domain containing 9
CCNJL cyclin J-like
CDK3 cyclin-dependent kinase 3
CDON cell adhesion associated, oncogene regulated
CEP295 centrosomal protein 295kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHMP6 charged multivesicular body protein 6
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLDN14 claudin 14
COCH cochlin
CRY2 cryptochrome circadian clock 2
CTSK cathepsin K
CXCL3 chemokine (C-X-C motif) ligand 3
DENND4A DENN/MADD domain containing 4A
DUSP8 dual specificity phosphatase 8
ECM1 extracellular matrix protein 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FANCE Fanconi anemia, complementation group E
FBXL7 F-box and leucine-rich repeat protein 7
FER fer (fps/fes related) tyrosine kinase
FGL1 fibrinogen-like 1
GJC1 gap junction protein, gamma 1, 45kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HDAC7 histone deacetylase 7
HIST1H2AI histone cluster 1, H2ai
HOXA2 homeobox A2
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL17RB interleukin 17 receptor B
KIAA0754 KIAA0754
LRP2 low density lipoprotein receptor-related protein 2
LYPD3 LY6/PLAUR domain containing 3
MAGEB2 melanoma antigen family B2
MCTP2 multiple C2 domains, transmembrane 2
MED15 mediator complex subunit 15
MT1M metallothionein 1M
MYO1D myosin ID
NINJ1 ninjurin 1
NLK nemo-like kinase
NUBP2 nucleotide binding protein 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PGPEP1 pyroglutamyl-peptidase I
PID1 phosphotyrosine interaction domain containing 1
PLA2G15 phospholipase A2, group XV
PLCD1 phospholipase C, delta 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNA3 plexin A3
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRPH peripherin
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RECQL4 RecQ protein-like 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLITRK5 SLIT and NTRK-like family, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SRD5A3 steroid 5 alpha-reductase 3
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STARD3 StAR-related lipid transfer (START) domain containing 3
STBD1 starch binding domain 1
THBS3 thrombospondin 3
TMEM132A transmembrane protein 132A
TMEM209 transmembrane protein 209
TRAF2 TNF receptor-associated factor 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC23 tetratricopeptide repeat domain 23
TTF2 transcription termination factor, RNA polymerase II
WDR18 WD repeat domain 18
YPEL1 yippee-like 1 (Drosophila)
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC18 zinc finger, DHHC-type containing 18
ZMAT5 zinc finger, matrin-type 5
ZNF137P zinc finger protein 137, pseudogene
ZNF84 zinc finger protein 84