etacrynic acid-3181 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the etacrynic acid-3181 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ADAM30 ADAM metallopeptidase domain 30
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOB aldolase B, fructose-bisphosphate
ARTN artemin
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC64 coiled-coil domain containing 64
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP250 centrosomal protein 250kDa
CIB2 calcium and integrin binding family member 2
CLDN10 claudin 10
COL10A1 collagen, type X, alpha 1
CSF1R colony stimulating factor 1 receptor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCBLD2 discoidin, CUB and LCCL domain containing 2
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUOX1 dual oxidase 1
EPAS1 endothelial PAS domain protein 1
EPX eosinophil peroxidase
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GM2A GM2 ganglioside activator
HCG4 HLA complex group 4 (non-protein coding)
HEG1 heart development protein with EGF-like domains 1
HEXA-AS1 HEXA antisense RNA 1
HMOX1 heme oxygenase 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF4 IKAROS family zinc finger 4 (Eos)
IL23A interleukin 23, alpha subunit p19
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KLHL1 kelch-like family member 1
KMT2A lysine (K)-specific methyltransferase 2A
KRT37 keratin 37, type I
KRTAP1-3 keratin associated protein 1-3
LMF2 lipase maturation factor 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR22HG MIR22 host gene
MR1 major histocompatibility complex, class I-related
MTMR3 myotubularin related protein 3
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NHLH2 nescient helix loop helix 2
NKG7 natural killer cell granule protein 7
NMT2 N-myristoyltransferase 2
NOL10 nucleolar protein 10
NTN3 netrin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OPRL1 opiate receptor-like 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
PAX2 paired box 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCLO piccolo presynaptic cytomatrix protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R17 protein phosphatase 1, regulatory subunit 17
PRDM9 PR domain containing 9
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RFPL2 ret finger protein-like 2
RGS20 regulator of G-protein signaling 20
RPH3A rabphilin 3A
RPL35A ribosomal protein L35a
SCGB1D1 secretoglobin, family 1D, member 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC25A30 solute carrier family 25, member 30
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM14 small integral membrane protein 14
SOS2 son of sevenless homolog 2 (Drosophila)
SPON1 spondin 1, extracellular matrix protein
SSX1 synovial sarcoma, X breakpoint 1
STK24 serine/threonine kinase 24
SYCP1 synaptonemal complex protein 1
TCF4 transcription factor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM10 tripartite motif containing 10
TXNRD1 thioredoxin reductase 1
UBE2I ubiquitin-conjugating enzyme E2I
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
YPEL1 yippee-like 1 (Drosophila)
ZNF423 zinc finger protein 423
ZNF440 zinc finger protein 440
ZNF506 zinc finger protein 506
ZNF814 zinc finger protein 814
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
AFAP1 actin filament associated protein 1
ALS2CL ALS2 C-terminal like
ANP32A-IT1 ANP32A intronic transcript 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
C11ORF30 chromosome 11 open reading frame 30
C12ORF4 chromosome 12 open reading frame 4
C9ORF9 chromosome 9 open reading frame 9
CA11 carbonic anhydrase XI
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CEP97 centrosomal protein 97kDa
CGREF1 cell growth regulator with EF-hand domain 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DOC2A double C2-like domains, alpha
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFNA3 ephrin-A3
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCE Fanconi anemia, complementation group E
FBXO5 F-box protein 5
FCHO1 FCH domain only 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLI3 GLI family zinc finger 3
GRB7 growth factor receptor-bound protein 7
H2AFJ H2A histone family, member J
HIRA histone cell cycle regulator
HOXC10 homeobox C10
HOXC5 homeobox C5
HOXC8 homeobox C8
HYAL2 hyaluronoglucosaminidase 2
IDI2-AS1 IDI2 antisense RNA 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KIF13A kinesin family member 13A
KIF1C kinesin family member 1C
KRT13 keratin 13, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDHB lactate dehydrogenase B
LHX1 LIM homeobox 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMNB1 lamin B1
LRP5 low density lipoprotein receptor-related protein 5
LRRC20 leucine rich repeat containing 20
LYZ lysozyme
MAP1S microtubule-associated protein 1S
MAST3 microtubule associated serine/threonine kinase 3
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTERF4 mitochondrial transcription termination factor 4
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PADI2 peptidyl arginine deiminase, type II
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G10 phospholipase A2, group X
PLEK2 pleckstrin 2
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PRR15L proline rich 15-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RIBC2 RIB43A domain with coiled-coils 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC3 syndecan 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SOX3 SRY (sex determining region Y)-box 3
SRGN serglycin
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX1A syntaxin 1A (brain)
TMEM120B transmembrane protein 120B
TRAF2 TNF receptor-associated factor 2
TRAIP TRAF interacting protein
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VAV1 vav 1 guanine nucleotide exchange factor
WDR25 WD repeat domain 25
ZNF34 zinc finger protein 34
ZNF675 zinc finger protein 675
ZNF696 zinc finger protein 696
ZNF778 zinc finger protein 778