etacrynic acid-1565 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the etacrynic acid-1565 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD3 abhydrolase domain containing 3
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
APOL2 apolipoprotein L, 2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
C2ORF49 chromosome 2 open reading frame 49
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD84 CD84 molecule
CLCN3 chloride channel, voltage-sensitive 3
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COX15 cytochrome c oxidase assembly homolog 15 (yeast)
CRTC1 CREB regulated transcription coactivator 1
CTSL cathepsin L
CYLD cylindromatosis (turban tumor syndrome)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DDB2 damage-specific DNA binding protein 2, 48kDa
EFHC1 EF-hand domain (C-terminal) containing 1
ELK1 ELK1, member of ETS oncogene family
FAM49B family with sequence similarity 49, member B
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GBAP1 glucosidase, beta, acid pseudogene 1
GCLM glutamate-cysteine ligase, modifier subunit
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GSR glutathione reductase
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BF histone cluster 1, H2bf
HTT huntingtin
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
ING4 inhibitor of growth family, member 4
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JRKL JRK-like
KIAA0232 KIAA0232
KIAA1033 KIAA1033
KIFAP3 kinesin-associated protein 3
LMAN2L lectin, mannose-binding 2-like
LPAR2 lysophosphatidic acid receptor 2
MAOA monoamine oxidase A
MARK4 MAP/microtubule affinity-regulating kinase 4
MDC1 mediator of DNA-damage checkpoint 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP2 matrix metallopeptidase 2
MSRB1 methionine sulfoxide reductase B1
MXD4 MAX dimerization protein 4
NBR1 neighbor of BRCA1 gene 1
NDFIP1 Nedd4 family interacting protein 1
NIPAL2 NIPA-like domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUCB1 nucleobindin 1
PCLO piccolo presynaptic cytomatrix protein
PGD phosphogluconate dehydrogenase
PHF21A PHD finger protein 21A
PHTF1 putative homeodomain transcription factor 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIR pirin (iron-binding nuclear protein)
PREPL prolyl endopeptidase-like
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOQ ras homolog family member Q
RIT1 Ras-like without CAAX 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPL13P5 ribosomal protein L13 pseudogene 5
RTEL1 regulator of telomere elongation helicase 1
SAMD9 sterile alpha motif domain containing 9
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS1 son of sevenless homolog 1 (Drosophila)
SQSTM1 sequestosome 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STRA6 stimulated by retinoic acid 6
SYNRG synergin, gamma
TESK1 testis-specific kinase 1
TFE3 transcription factor binding to IGHM enhancer 3
TFEC transcription factor EC
TPM1 tropomyosin 1 (alpha)
TPST1 tyrosylprotein sulfotransferase 1
TRADD TNFRSF1A-associated via death domain
TRAPPC11 trafficking protein particle complex 11
TRIB2 tribbles pseudokinase 2
TRIM68 tripartite motif containing 68
TUFT1 tuftelin 1
TULP3 tubby like protein 3
TXNRD1 thioredoxin reductase 1
UBE4B ubiquitination factor E4B
UNKL unkempt family zinc finger-like
USF2 upstream transcription factor 2, c-fos interacting
VWA5A von Willebrand factor A domain containing 5A
WDR45 WD repeat domain 45
XPO1 exportin 1
ZNF516 zinc finger protein 516
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ASB13 ankyrin repeat and SOCS box containing 13
BATF3 basic leucine zipper transcription factor, ATF-like 3
BEX1 brain expressed, X-linked 1
C10ORF2 chromosome 10 open reading frame 2
C11ORF48
C1ORF123 chromosome 1 open reading frame 123
CA2 carbonic anhydrase II
CARM1 coactivator-associated arginine methyltransferase 1
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CD3EAP CD3e molecule, epsilon associated protein
CLUH clustered mitochondria (cluA/CLU1) homolog
CSK c-src tyrosine kinase
CTPS1 CTP synthase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
FARSA phenylalanyl-tRNA synthetase, alpha subunit
GFI1 growth factor independent 1 transcription repressor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX5 glutaredoxin 5
GMPPB GDP-mannose pyrophosphorylase B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HELLS helicase, lymphoid-specific
HOMER1 homer scaffolding protein 1
IER3 immediate early response 3
IL2RG interleukin 2 receptor, gamma
KIAA0020 KIAA0020
KIF21B kinesin family member 21B
LAS1L LAS1-like (S. cerevisiae)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMNB2 lamin B2
LOC642236 FSHD region gene 1 pseudogene
LPL lipoprotein lipase
MAGOHB mago-nashi homolog B (Drosophila)
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPV17 MpV17 mitochondrial inner membrane protein
MRPL17 mitochondrial ribosomal protein L17
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NOLC1 nucleolar and coiled-body phosphoprotein 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PADI1 peptidyl arginine deiminase, type I
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PES1 pescadillo ribosomal biogenesis factor 1
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAN peter pan homolog (Drosophila)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCR1 pyrroline-5-carboxylate reductase 1
RCL1 RNA terminal phosphate cyclase-like 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RPP14 ribonuclease P/MRP 14kDa subunit
RRP1 ribosomal RNA processing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SDF2L1 stromal cell-derived factor 2-like 1
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEH1L SEH1-like (S. cerevisiae)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
STRA13 stimulated by retinoic acid 13
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TERT telomerase reverse transcriptase
TESC tescalcin
TFB2M transcription factor B2, mitochondrial
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRHDE thyrotropin-releasing hormone degrading enzyme
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTF2 transcription termination factor, RNA polymerase II
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UCK2 uridine-cytidine kinase 2
UNG uracil-DNA glycosylase
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WDYHV1 WDYHV motif containing 1
ZNF593 zinc finger protein 593