estradiol-7000 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the estradiol-7000 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
APLP1 amyloid beta (A4) precursor-like protein 1
ARRB1 arrestin, beta 1
ASIC1 acid sensing (proton gated) ion channel 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CCDC93 coiled-coil domain containing 93
CD44 CD44 molecule (Indian blood group)
CDHR2 cadherin-related family member 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDON cell adhesion associated, oncogene regulated
CENPT centromere protein T
CLMN calmin (calponin-like, transmembrane)
COL8A1 collagen, type VIII, alpha 1
CPED1 cadherin-like and PC-esterase domain containing 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGKA diacylglycerol kinase, alpha 80kDa
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOC2A double C2-like domains, alpha
DPYSL4 dihydropyrimidinase-like 4
DSPP dentin sialophosphoprotein
EFNB3 ephrin-B3
EGR3 early growth response 3
EHD1 EH-domain containing 1
EPHB3 EPH receptor B3
EXT1 exostosin glycosyltransferase 1
FAM198B family with sequence similarity 198, member B
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZD7 frizzled class receptor 7
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
IGFBP5 insulin-like growth factor binding protein 5
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KIF13B kinesin family member 13B
KLF6 Kruppel-like factor 6
KRIT1 KRIT1, ankyrin repeat containing
LMNB1 lamin B1
MAP4 microtubule-associated protein 4
MAST2 microtubule associated serine/threonine kinase 2
MBD1 methyl-CpG binding domain protein 1
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MYO9B myosin IXB
NAV2 neuron navigator 2
NF2 neurofibromin 2 (merlin)
NPY1R neuropeptide Y receptor Y1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NYNRIN NYN domain and retroviral integrase containing
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
ORAI2 ORAI calcium release-activated calcium modulator 2
ORC5 origin recognition complex, subunit 5
PAQR6 progestin and adipoQ receptor family member VI
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDZK1 PDZ domain containing 1
PER1 period circadian clock 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKNOX1 PBX/knotted 1 homeobox 1
PLSCR3 phospholipid scramblase 3
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRPF18 pre-mRNA processing factor 18
PRR5 proline rich 5 (renal)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRE protein tyrosine phosphatase, receptor type, E
RANBP1 RAN binding protein 1
RPS14 ribosomal protein S14
SETD8 SET domain containing (lysine methyltransferase) 8
SGSM2 small G protein signaling modulator 2
SH3BP2 SH3-domain binding protein 2
SIX2 SIX homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SOGA1 suppressor of glucose, autophagy associated 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
SUGP1 SURP and G patch domain containing 1
SYT12 synaptotagmin XII
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAPBP TAP binding protein (tapasin)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPP1 tripeptidyl peptidase I
XK X-linked Kx blood group
ZC3H7B zinc finger CCCH-type containing 7B
ZFHX4 zinc finger homeobox 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF16 zinc finger protein 16
ZNF528 zinc finger protein 528
ZNF783 zinc finger family member 783
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ALPK1 alpha-kinase 1
ANKRD36 ankyrin repeat domain 36
ARHGAP10 Rho GTPase activating protein 10
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD5 ATPase family, AAA domain containing 5
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BATF basic leucine zipper transcription factor, ATF-like
BBS1 Bardet-Biedl syndrome 1
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF80 chromosome 11 open reading frame 80
C14ORF132 chromosome 14 open reading frame 132
C2ORF44 chromosome 2 open reading frame 44
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHML choroideremia-like (Rab escort protein 2)
CLCN5 chloride channel, voltage-sensitive 5
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DEAF1 DEAF1 transcription factor
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHDDS dehydrodolichyl diphosphate synthase
EFCAB2 EF-hand calcium binding domain 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM111A family with sequence similarity 111, member A
FAM114A2 family with sequence similarity 114, member A2
FBXL6 F-box and leucine-rich repeat protein 6
FBXO31 F-box protein 31
FGGY FGGY carbohydrate kinase domain containing
FLCN folliculin
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
FURIN furin (paired basic amino acid cleaving enzyme)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GRTP1 growth hormone regulated TBC protein 1
HCFC2 host cell factor C2
HMBOX1 homeobox containing 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFT140 intraflagellar transport 140
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF2 interferon regulatory factor 2
JMJD4 jumonji domain containing 4
KDM8 lysine (K)-specific demethylase 8
KLF2 Kruppel-like factor 2
LAMA5 laminin, alpha 5
LHFPL2 lipoma HMGIC fusion partner-like 2
LIG4 ligase IV, DNA, ATP-dependent
LOC100272216 uncharacterized LOC100272216
LRRC37A2 leucine rich repeat containing 37, member A2
LY6D lymphocyte antigen 6 complex, locus D
MAP9 microtubule-associated protein 9
MAPK12 mitogen-activated protein kinase 12
MBTD1 mbt domain containing 1
METTL2B methyltransferase like 2B
MFAP2 microfibrillar-associated protein 2
OSMR oncostatin M receptor
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCDHA5 protocadherin alpha 5
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
PRPH peripherin
RIPK4 receptor-interacting serine-threonine kinase 4
RNF123 ring finger protein 123
ROM1 retinal outer segment membrane protein 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SBNO2 strawberry notch homolog 2 (Drosophila)
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SH2D4A SH2 domain containing 4A
SLC46A3 solute carrier family 46, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSFA2 sperm specific antigen 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX5 syntaxin 5
TEP1 telomerase-associated protein 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM180 transmembrane protein 180
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
TRIM66 tripartite motif containing 66
TUBG2 tubulin, gamma 2
USP20 ubiquitin specific peptidase 20
VAV1 vav 1 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
WDR33 WD repeat domain 33
WDR4 WD repeat domain 4
WDR60 WD repeat domain 60
WDR91 WD repeat domain 91
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF134 zinc finger protein 134
ZNF141 zinc finger protein 141
ZNF432 zinc finger protein 432
ZNF665 zinc finger protein 665
ZNF767P zinc finger family member 767, pseudogene