estradiol-1079 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the estradiol-1079 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP44 Rho GTPase activating protein 44
ARID4A AT rich interactive domain 4A (RBP1-like)
ARMC8 armadillo repeat containing 8
ATP11A ATPase, class VI, type 11A
AXIN1 axin 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP1 bone morphogenetic protein 1
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C11ORF80 chromosome 11 open reading frame 80
C17ORF75 chromosome 17 open reading frame 75
C5ORF45 chromosome 5 open reading frame 45
CCNG2 cyclin G2
CENPQ centromere protein Q
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CREBZF CREB/ATF bZIP transcription factor
CRYL1 crystallin, lambda 1
CTBS chitobiase, di-N-acetyl-
CXCL12 chemokine (C-X-C motif) ligand 12
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DIAPH1 diaphanous-related formin 1
DND1 DND microRNA-mediated repression inhibitor 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
EFNA3 ephrin-A3
EGR3 early growth response 3
EID1 EP300 interacting inhibitor of differentiation 1
EIF1 eukaryotic translation initiation factor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS3 fatty acid desaturase 3
FEM1C fem-1 homolog c (C. elegans)
FGFR2 fibroblast growth factor receptor 2
FOXC1 forkhead box C1
FRS2 fibroblast growth factor receptor substrate 2
FXR2 fragile X mental retardation, autosomal homolog 2
GADD45B growth arrest and DNA-damage-inducible, beta
HABP4 hyaluronan binding protein 4
HSF1 heat shock transcription factor 1
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KDM5C lysine (K)-specific demethylase 5C
KLHL22 kelch-like family member 22
KPTN kaptin (actin binding protein)
MANEA mannosidase, endo-alpha
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCAPH2 non-SMC condensin II complex, subunit H2
NIPBL Nipped-B homolog (Drosophila)
NKAIN1 Na+/K+ transporting ATPase interacting 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OGFR opioid growth factor receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PDZK1 PDZ domain containing 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK4 polo-like kinase 4
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPIA peptidylprolyl isomerase A (cyclophilin A)
PTBP3 polypyrimidine tract binding protein 3
PVR poliovirus receptor
RAB28 RAB28, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RPAP1 RNA polymerase II associated protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLK STE20-like kinase
SMA4 glucuronidase, beta pseudogene
SNORA21 small nucleolar RNA, H/ACA box 21
SOAT1 sterol O-acyltransferase 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STC1 stanniocalcin 1
STX2 syntaxin 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBL1X transducin (beta)-like 1X-linked
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM194A transmembrane protein 194A
TMEM2 transmembrane protein 2
TOP3A topoisomerase (DNA) III alpha
TWF2 twinfilin actin binding protein 2
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBE3C ubiquitin protein ligase E3C
WDHD1 WD repeat and HMG-box DNA binding protein 1
WDR48 WD repeat domain 48
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZDHHC17 zinc finger, DHHC-type containing 17
ZMAT5 zinc finger, matrin-type 5
ZNF124 zinc finger protein 124

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
ANKMY2 ankyrin repeat and MYND domain containing 2
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARMC7 armadillo repeat containing 7
ASB8 ankyrin repeat and SOCS box containing 8
ATG2A autophagy related 2A
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BBC3 BCL2 binding component 3
C12ORF43 chromosome 12 open reading frame 43
C19ORF24 chromosome 19 open reading frame 24
C1ORF216 chromosome 1 open reading frame 216
C2CD2 C2 calcium-dependent domain containing 2
C5 complement component 5
CBR4 carbonyl reductase 4
CCNL2 cyclin L2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP83 centrosomal protein 83kDa
CHKB choline kinase beta
CHMP7 charged multivesicular body protein 7
CLDN9 claudin 9
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CRABP2 cellular retinoic acid binding protein 2
CTSV cathepsin V
DAAM1 dishevelled associated activator of morphogenesis 1
DHDDS dehydrodolichyl diphosphate synthase
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNA2 DNA replication helicase/nuclease 2
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
ECD ecdysoneless homolog (Drosophila)
ECHDC3 enoyl CoA hydratase domain containing 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
ERCC5 excision repair cross-complementation group 5
FAM114A2 family with sequence similarity 114, member A2
FAM172A family with sequence similarity 172, member A
FBXO46 F-box protein 46
FDXR ferredoxin reductase
FOCAD focadhesin
FOXJ2 forkhead box J2
GAREM GRB2 associated, regulator of MAPK1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
HIST1H1C histone cluster 1, H1c
HIST1H2BF histone cluster 1, H2bf
HPS6 Hermansky-Pudlak syndrome 6
IP6K1 inositol hexakisphosphate kinase 1
JADE1 jade family PHD finger 1
JUNB jun B proto-oncogene
KLHL21 kelch-like family member 21
LIN37 lin-37 DREAM MuvB core complex component
LRP10 low density lipoprotein receptor-related protein 10
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MB myoglobin
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYLIP myosin regulatory light chain interacting protein
NABP2 nucleic acid binding protein 2
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NSD1 nuclear receptor binding SET domain protein 1
NUBPL nucleotide binding protein-like
ORC3 origin recognition complex, subunit 3
PADI2 peptidyl arginine deiminase, type II
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDZRN3 PDZ domain containing ring finger 3
PKN1 protein kinase N1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PPOX protoporphyrinogen oxidase
PRSS8 protease, serine, 8
QTRT1 queuine tRNA-ribosyltransferase 1
RIPK4 receptor-interacting serine-threonine kinase 4
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIL1 SIL1 nucleotide exchange factor
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYTL2 synaptotagmin-like 2
TESK2 testis-specific kinase 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM115 transmembrane protein 115
TMEM132A transmembrane protein 132A
TMEM183A transmembrane protein 183A
TRIP10 thyroid hormone receptor interactor 10
TXLNA taxilin alpha
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UNC13B unc-13 homolog B (C. elegans)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDR60 WD repeat domain 60
ZMYM3 zinc finger, MYM-type 3
ZNF672 zinc finger protein 672
ZNF675 zinc finger protein 675
ZNF721 zinc finger protein 721