essential tremor Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms. (Human Disease Ontology, DOID_4990)
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Genes

110 genes co-occuring with the disease essential tremor in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
VIM vimentin 3.13307
HS1BP3 HCLS1 binding protein 3 2.67443
LINGO1 leucine rich repeat and Ig domain containing 1 2.63691
DRD3 dopamine receptor D3 2.01659
LINGO2 leucine rich repeat and Ig domain containing 2 1.90847
CAMP cathelicidin antimicrobial peptide 1.57467
FUS FUS RNA binding protein 1.53216
LINGO4 leucine rich repeat and Ig domain containing 4 1.3027
ANO3 anoctamin 3 1.29221
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 1.22215
LAPTM4A lysosomal protein transmembrane 4 alpha 1.20613
RTN4R reticulon 4 receptor 1.20137
PUM2 pumilio RNA-binding family member 2 1.1194
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.11393
GCH1 GTP cyclohydrolase 1 1.069
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 1.05976
GIGYF2 GRB10 interacting GYF protein 2 1.0484
RPGRIP1L RPGRIP1-like 1.0303
LRRK2 leucine-rich repeat kinase 2 1.02018
NADK NAD kinase 1.00246
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.964567
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 0.913903
MANF mesencephalic astrocyte-derived neurotrophic factor 0.906086
SYT12 synaptotagmin XII 0.896641
HNMT histamine N-methyltransferase 0.881882
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.84544
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.840525
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.837656
BTBD9 BTB (POZ) domain containing 9 0.831099
CALB1 calbindin 1, 28kDa 0.830279
SYT11 synaptotagmin XI 0.804846
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.778204
ACMSD aminocarboxymuconate semialdehyde decarboxylase 0.762678
FMR1 fragile X mental retardation 1 0.757786
HIP1R huntingtin interacting protein 1 related 0.739082
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.738676
OMD osteomodulin 0.737054
RBPMS RNA binding protein with multiple splicing 0.733811
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.718039
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.685491
CCDC62 coiled-coil domain containing 62 0.664769
C9ORF72 chromosome 9 open reading frame 72 0.647348
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.638676
CHM choroideremia (Rab escort protein 1) 0.626103
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.613183
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.604201
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.583163
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.570718
STK39 serine threonine kinase 39 0.562946
PORCN porcupine homolog (Drosophila) 0.559839
HTRA2 HtrA serine peptidase 2 0.556732
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.550522
NONO non-POU domain containing, octamer-binding 0.543155
TAS1R1 taste receptor, type 1, member 1 0.533475
ADORA1 adenosine A1 receptor 0.517265
ADRB2 adrenoceptor beta 2, surface 0.506507
THAP1 THAP domain containing, apoptosis associated protein 1 0.496175
FGF20 fibroblast growth factor 20 0.488549
GJD2 gap junction protein, delta 2, 36kDa 0.479807
HRC histidine rich calcium binding protein 0.478668
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.469197
PRRT2 proline-rich transmembrane protein 2 0.467684
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 0.466928
MAPT microtubule-associated protein tau 0.451078
PANK1 pantothenate kinase 1 0.448441
RGMB repulsive guidance molecule family member b 0.42289
SGCE sarcoglycan, epsilon 0.418394
FRS2 fibroblast growth factor receptor substrate 2 0.405678
SCG2 secretogranin II 0.403811
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.397843
ATG4C autophagy related 4C, cysteine peptidase 0.393001
GRM4 glutamate receptor, metabotropic 4 0.392257
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.391513
SNCAIP synuclein, alpha interacting protein 0.390397
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.385936
GBA glucosidase, beta, acid 0.374068
CHGB chromogranin B 0.355235
MRPL49 mitochondrial ribosomal protein L49 0.347511
COMT catechol-O-methyltransferase 0.346777
SETX senataxin 0.332121
AR androgen receptor 0.330295
MATN3 matrilin 3 0.320817
LST1 leukocyte specific transcript 1 0.307757
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.29118
PANK2 pantothenate kinase 2 0.288668
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.282582
ALAD aminolevulinate dehydratase 0.265849
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.263368
NEFM neurofilament, medium polypeptide 0.262306
A2M alpha-2-macroglobulin 0.258417
MIXL1 Mix paired-like homeobox 0.257005
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.256299
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.243995
EWSR1 EWS RNA-binding protein 1 0.242245
FEN1 flap structure-specific endonuclease 1 0.239101
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.230063
MEIS1 Meis homeobox 1 0.224884
PARK2 parkin RBR E3 ubiquitin protein ligase 0.221793
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.220766
MAOB monoamine oxidase B 0.217012
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.210589
ASS1 argininosuccinate synthase 1 0.20229
GDNF glial cell derived neurotrophic factor 0.200656
TH tyrosine hydroxylase 0.194865
RET ret proto-oncogene 0.191408
PRSS21 protease, serine, 21 (testisin) 0.185313
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.179239
NEFH neurofilament, heavy polypeptide 0.171036
ADORA2A adenosine A2a receptor 0.16933
AFF2 AF4/FMR2 family, member 2 0.167915