essential hypertension Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A hypertension with no known cause. It is the most common type of hypertension. (Human Disease Ontology, DOID_10825)
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Genes

334 genes co-occuring with the disease essential hypertension in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
REN renin 3.66094
ACE angiotensin I converting enzyme 2.74289
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.33497
NPPA natriuretic peptide A 2.23033
ADD1 adducin 1 (alpha) 1.9769
INS insulin 1.93421
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.91734
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 1.84045
ALB albumin 1.81374
DNAH8 dynein, axonemal, heavy chain 8 1.6624
KNG1 kininogen 1 1.59787
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.58983
SELENBP1 selenium binding protein 1 1.5014
AGTR1 angiotensin II receptor, type 1 1.50096
EDN1 endothelin 1 1.41797
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.41183
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.37556
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.35725
NOS3 nitric oxide synthase 3 (endothelial cell) 1.31013
POMC proopiomelanocortin 1.28435
CRP C-reactive protein, pentraxin-related 1.2656
ADRB1 adrenoceptor beta 1 1.25167
ADRB2 adrenoceptor beta 2, surface 1.23212
WNK4 WNK lysine deficient protein kinase 4 1.22562
ADM adrenomedullin 1.20872
GRK4 G protein-coupled receptor kinase 4 1.17808
MGAM maltase-glucoamylase 1.15496
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.12277
AVP arginine vasopressin 1.11393
PTH parathyroid hormone 1.1051
APOB apolipoprotein B 1.06606
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.06396
WNK1 WNK lysine deficient protein kinase 1 1.03198
ADD2 adducin 2 (beta) 1.03114
ADRA1D adrenoceptor alpha 1D 1.01765
ACE2 angiotensin I converting enzyme 2 1.01554
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.988535
KLK1 kallikrein 1 0.987693
UTS2 urotensin 2 0.980531
NPY neuropeptide Y 0.978426
LEP leptin 0.97002
MME membrane metallo-endopeptidase 0.918436
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.892538
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.891308
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.890488
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.88434
VWF von Willebrand factor 0.865502
CLCNKB chloride channel, voltage-sensitive Kb 0.862228
ADRA2B adrenoceptor alpha 2B 0.856087
ADD3 adducin 3 (gamma) 0.848716
NTS neurotensin 0.845031
CHGA chromogranin A 0.835607
DNM2 dynamin 2 0.791721
PLG plasminogen 0.785165
INSR insulin receptor 0.783526
BDKRB2 bradykinin receptor B2 0.781888
SOD2 superoxide dismutase 2, mitochondrial 0.779841
COG2 component of oligomeric golgi complex 2 0.776568
PTGIS prostaglandin I2 (prostacyclin) synthase 0.769618
EMILIN1 elastin microfibril interfacer 1 0.76921
EDNRA endothelin receptor type A 0.768801
C4ORF22 chromosome 4 open reading frame 22 0.752898
TMEM38A transmembrane protein 38A 0.752898
CALCA calcitonin-related polypeptide alpha 0.751678
PLAT plasminogen activator, tissue 0.750457
MLX MLX, MAX dimerization protein 0.748424
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.746391
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 0.738676
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.737054
APOA1 apolipoprotein A-I 0.730976
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.730571
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.728143
LATS2 large tumor suppressor kinase 2 0.723694
EDN2 endothelin 2 0.722482
THBD thrombomodulin 0.718443
ADRA1A adrenoceptor alpha 1A 0.717232
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.71078
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.696707
PLCD3 phospholipase C, delta 3 0.687891
MGP matrix Gla protein 0.678701
FMO3 flavin containing monooxygenase 3 0.676706
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.67551
SELE selectin E 0.674713
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.66914
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.654858
STK39 serine threonine kinase 39 0.654858
C5ORF38 chromosome 5 open reading frame 38 0.653671
CD164L2 CD164 sialomucin-like 2 0.646559
KIN Kin17 DNA and RNA binding protein 0.632384
PPARG peroxisome proliferator-activated receptor gamma 0.630027
PNMT phenylethanolamine N-methyltransferase 0.630027
IL6 interleukin 6 0.630027
NFYB nuclear transcription factor Y, beta 0.627672
CTF1 cardiotrophin 1 0.620226
GCGR glucagon receptor 0.617877
NPPB natriuretic peptide B 0.616703
NPPC natriuretic peptide C 0.615921
ADRB3 adrenoceptor beta 3 0.615529
TAC1 tachykinin, precursor 1 0.611229
ADCY2 adenylate cyclase 2 (brain) 0.607323
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.606152
ICAM1 intercellular adhesion molecule 1 0.60108
LPA lipoprotein, Lp(a) 0.60108
NPR3 natriuretic peptide receptor 3 0.594454
CMA1 chymase 1, mast cell 0.592506
CAT catalase 0.590169
F11R F11 receptor 0.586276
AMBP alpha-1-microglobulin/bikunin precursor 0.578494
GPX1 glutathione peroxidase 1 0.576161
HPR haptoglobin-related protein 0.575383
LPL lipoprotein lipase 0.568775
MTMR4 myotubularin related protein 4 0.56722
RGS2 regulator of G-protein signaling 2 0.564889
CST3 cystatin C 0.563723
RETN resistin 0.555956
GCG glucagon 0.554015
PCP2 Purkinje cell protein 2 0.553239
RENBP renin binding protein 0.548971
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.547032
PF4 platelet factor 4 0.539667
TBK1 TANK-binding kinase 1 0.530381
B2M beta-2-microglobulin 0.528449
GPX4 glutathione peroxidase 4 0.528449
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.523816
HP haptoglobin 0.522659
IGF1 insulin-like growth factor 1 (somatomedin C) 0.517265
VAT1 vesicle amine transport 1 0.517265
ZNF652 zinc finger protein 652 0.515725
WSCD2 WSC domain containing 2 0.508808
PRR11 proline rich 11 0.508808
GPX5 glutathione peroxidase 5 0.507273
APOA2 apolipoprotein A-II 0.505356
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.50459
TGFB1 transforming growth factor, beta 1 0.497703
LACTB lactamase, beta 0.497321
VCAM1 vascular cell adhesion molecule 1 0.493503
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.487407
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 0.487027
PRAM1 PML-RARA regulated adaptor molecule 1 0.481705
RNPEP arginyl aminopeptidase (aminopeptidase B) 0.476014
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.475634
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 0.47374
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.472604
TNF tumor necrosis factor 0.455601
PRDM8 PR domain containing 8 0.455601
APOE apolipoprotein E 0.450701
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.449947
CCNA2 cyclin A2 0.44129
MEX3C mex-3 RNA binding family member C 0.438658
PPP1R12C protein phosphatase 1, regulatory subunit 12C 0.434899
PRSS8 protease, serine, 8 0.431144
PSTK phosphoseryl-tRNA kinase 0.431144
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.428516
RABAC1 Rab acceptor 1 (prenylated) 0.42289
TIMP1 TIMP metallopeptidase inhibitor 1 0.421016
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.420641
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.419142
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.41727
RPS19 ribosomal protein S19 0.416147
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 0.41465
LEPR leptin receptor 0.413901
ATP11A ATPase, class VI, type 11A 0.411283
YME1L1 YME1-like 1 ATPase 0.410161
IRS1 insulin receptor substrate 1 0.409414
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.40904
TOR2A torsin family 2, member A 0.406798
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.406425
GOSR1 golgi SNAP receptor complex member 1 0.402692
ERAP1 endoplasmic reticulum aminopeptidase 1 0.401945
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.401572
ADRA2A adrenoceptor alpha 2A 0.399707
GOSR2 golgi SNAP receptor complex member 2 0.394118
COMT catechol-O-methyltransferase 0.393001
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.380368
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.378514
PRCP prolylcarboxypeptidase (angiotensinase C) 0.378143
BFAR bifunctional apoptosis regulator 0.377031
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.37629
SCN7A sodium channel, voltage gated, type VII alpha subunit 0.37592
UTS2R urotensin 2 receptor 0.37555
ULK4 unc-51 like kinase 4 0.373698
LCAT lecithin-cholesterol acyltransferase 0.368149
DCLRE1C DNA cross-link repair 1C 0.36741
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.364824
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.364085
TBXAS1 thromboxane A synthase 1 (platelet) 0.363716
AVPR1A arginine vasopressin receptor 1A 0.360026
NXPH4 neurexophilin 4 0.357077
FGD1 FYVE, RhoGEF and PH domain containing 1 0.353027
ALPK2 alpha-kinase 2 0.351187
UFL1 UFM1-specific ligase 1 0.346409
TH tyrosine hydroxylase 0.346409
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.342006
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.338341
PRL prolactin 0.338341
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.336876
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.335778
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 0.335412
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 0.335412
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.333218
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.332487
APOC3 apolipoprotein C-III 0.328834
SNX5 sorting nexin 5 0.323365
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.323365
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.322273
KYNU kynureninase 0.321545
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.318635
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.313189
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.310652
SPP1 secreted phosphoprotein 1 0.310652
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.31029
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.30848
CAST calpastatin 0.304142
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.30342
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.30342
CD2 CD2 molecule 0.301976
OGN osteoglycin 0.298011
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 0.297651
LEMD1 LEM domain containing 1 0.292975
ECE2 endothelin converting enzyme 2 0.291539
DLL1 delta-like 1 (Drosophila) 0.288668
DRD1 dopamine receptor D1 0.287235
ECE1 endothelin converting enzyme 1 0.287235
APCDD1 adenomatosis polyposis coli down-regulated 1 0.28616
TRH thyrotropin-releasing hormone 0.284371
IGLV3-9 immunoglobulin lambda variable 3-9 (gene/pseudogene) 0.283655
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.27794
GTF2IRD2 GTF2I repeat domain containing 2 0.275089
FOS FBJ murine osteosarcoma viral oncogene homolog 0.274376
HAP1 huntingtin-associated protein 1 0.273308
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.269753
CSN3 casein kappa 0.266558
MIRLET7E microRNA let-7e 0.263722
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.261599
FKBP1B FK506 binding protein 1B, 12.6 kDa 0.257005
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.255241
BDKRB1 bradykinin receptor B1 0.254536
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.253831
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.252422
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.251718
CCL2 chemokine (C-C motif) ligand 2 0.248905
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.248203
NEFH neurofilament, heavy polypeptide 0.247852
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.246448
NPS neuropeptide S 0.245046
SGK1 serum/glucocorticoid regulated kinase 1 0.244345
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.242945
FBL fibrillarin 0.242595
ACADSB acyl-CoA dehydrogenase, short/branched chain 0.241196
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.240148
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.23945
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.237706
CCDC27 coiled-coil domain containing 27 0.23666
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 0.236312
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.233878
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.232489
VIP vasoactive intestinal peptide 0.232489
EDN3 endothelin 3 0.231448
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.22937
HBA2 hemoglobin, alpha 2 0.22937
SLCO4C1 solute carrier organic anion transporter family, member 4C1 0.229024
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.227297
ATP13A1 ATPase type 13A1 0.227297
EXOC7 exocyst complex component 7 0.226607
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.223509
CRH corticotropin releasing hormone 0.216332
PLCD1 phospholipase C, delta 1 0.215653
HCCAT5 hepatocellular carcinoma associated transcript 5 (non-protein coding) 0.212271
IGLV2-8 immunoglobulin lambda variable 2-8 0.210589
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.209918
GPA33 glycoprotein A33 (transmembrane) 0.209918
SHROOM3 shroom family member 3 0.208245
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.208245
ULK3 unc-51 like kinase 3 0.207578
NPFF neuropeptide FF-amide peptide precursor 0.203604
AGTR2 angiotensin II receptor, type 2 0.202618
PNMA6A paraneoplastic Ma antigen family member 6A 0.202618
LDLR low density lipoprotein receptor 0.201308
SCARB2 scavenger receptor class B, member 2 0.200006
ETV3 ets variant 3 0.199033
ADHFE1 alcohol dehydrogenase, iron containing, 1 0.198709
IGLV1-36 immunoglobulin lambda variable 1-36 0.19742
FGF5 fibroblast growth factor 5 0.194232
FBLL1 fibrillarin-like 1 0.192971
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.189551
NAP1L2 nucleosome assembly protein 1-like 2 0.188326
NPR1 natriuretic peptide receptor 1 0.188022
IGLL5 immunoglobulin lambda-like polypeptide 5 0.187314
CD36 CD36 molecule (thrombospondin receptor) 0.186811
POMP proteasome maturation protein 0.185313
MYH9 myosin, heavy chain 9, non-muscle 0.184424
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.182666
MMP9 matrix metallopeptidase 9 0.182666
SNX1 sorting nexin 1 0.182375
FBN1 fibrillin 1 0.181798
UMOD uromodulin 0.181798
AIRE autoimmune regulator 0.18151
PON1 paraoxonase 1 0.180367
OTP orthopedia homeobox 0.179802
PDE5A phosphodiesterase 5A, cGMP-specific 0.179802
HBA1 hemoglobin, alpha 1 0.179239
SPTA1 spectrin, alpha, erythrocytic 1 0.17896
SRI sorcin 0.178682
RGS5 regulator of G-protein signaling 5 0.178126
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.176757
IRS2 insulin receptor substrate 2 0.175411
HLA-DMA major histocompatibility complex, class II, DM alpha 0.174617
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.172799
ABR active BCR-related 0.172291
NOS1 nitric oxide synthase 1 (neuronal) 0.171785
CYBA cytochrome b-245, alpha polypeptide 0.170544
SST somatostatin 0.169571
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.165655
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 0.165435
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.164571
TREH trehalase (brush-border membrane glycoprotein) 0.163938
DNM1 dynamin 1 0.163729
PNMA1 paraneoplastic Ma antigen 1 0.163523
SOAT1 sterol O-acyltransferase 1 0.162908
NTSR1 neurotensin receptor 1 (high affinity) 0.162505
RHOA ras homolog family member A 0.162306
LNPEP leucyl/cystinyl aminopeptidase 0.162109
F2 coagulation factor II (thrombin) 0.161331
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.160387
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.160203
SCARB1 scavenger receptor class B, member 1 0.160021
NOS2 nitric oxide synthase 2, inducible 0.159838
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.159302
HMOX2 heme oxygenase 2 0.158605
TSGA10 testis specific, 10 0.157929
HBD hemoglobin, delta 0.144934
HBB hemoglobin, beta 0.144173
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.142308
HLA-A major histocompatibility complex, class I, A 0.139702