esophageal neoplasms; head and neck neoplasms; laryngeal neoplasms; mouth neoplasms; pharyngeal neoplasms Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group cancer (Genetic Association Database)
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Genes

59 genes associated with the disease esophageal neoplasms; head and neck neoplasms; laryngeal neoplasms; mouth neoplasms; pharyngeal neoplasms in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKK1 ankyrin repeat and kinase domain containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
COMT catechol-O-methyltransferase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DEC1 deleted in esophageal cancer 1
DLEC1 deleted in lung and esophageal cancer 1
DRD2 dopamine receptor D2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
FANCG Fanconi anemia, complementation group G
FHIT fragile histidine triad
GJB5 gap junction protein, beta 5, 31.1kDa
GSTA2 glutathione S-transferase alpha 2
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
IL1R1 interleukin 1 receptor, type I
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KDM4C lysine (K)-specific demethylase 4C
LIG3 ligase III, DNA, ATP-dependent
LTBP1 latent transforming growth factor beta binding protein 1
LZTS1 leucine zipper, putative tumor suppressor 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NQO1 NAD(P)H dehydrogenase, quinone 1
OGG1 8-oxoguanine DNA glycosylase
PCNA proliferating cell nuclear antigen
POLB polymerase (DNA directed), beta
SOD2 superoxide dismutase 2, mitochondrial
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNF tumor necrosis factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TP53 tumor protein p53
TYMS thymidylate synthetase
WRAP53 WD repeat containing, antisense to TP53
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3