esophageal cancer Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A gastrointestinal system cancer that is located_in the esophagus. (Human Disease Ontology, DOID_5041)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:5041
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Genes

166 genes associated with the disease esophageal cancer in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.99483
FUT2 fucosyltransferase 2 (secretor status included) 3.51446
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 3.08092
APOE apolipoprotein E 2.80494
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.69543
PLCE1 phospholipase C, epsilon 1 2.62232
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.42814
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.40544
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.29198
CHEK2 checkpoint kinase 2 2.07674
FAM3B family with sequence similarity 3, member B 2.07237
RUNX1 runt-related transcription factor 1 2.0635
ACAD10 acyl-CoA dehydrogenase family, member 10 2.03641
HEATR3 HEAT repeat containing 3 2.01898
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 2.00953
RASIP1 Ras interacting protein 1 1.99432
PDE4D phosphodiesterase 4D, cAMP-specific 1.98052
AFP alpha-fetoprotein 1.93944
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 1.88168
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 1.82832
XBP1 X-box binding protein 1 1.80795
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 1.78856
CHRM2 cholinergic receptor, muscarinic 2 1.78507
DBP D site of albumin promoter (albumin D-box) binding protein 1.76717
SEC1P secretory blood group 1, pseudogene 1.76045
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.75752
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 1.75142
FCRL6 Fc receptor-like 6 1.749
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 1.72112
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 1.69848
TRAFD1 TRAF-type zinc finger domain containing 1 1.65258
BRAP BRCA1 associated protein 1.65185
RPL18 ribosomal protein L18 1.65109
CCDC63 coiled-coil domain containing 63 1.64727
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 1.64472
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.62029
SMG6 SMG6 nonsense mediated mRNA decay factor 1.62029
SLC22A17 solute carrier family 22, member 17 1.61215
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 1.58623
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 1.54181
PES1 pescadillo ribosomal biogenesis factor 1 1.51698
SYK spleen tyrosine kinase 1.51474
LPA lipoprotein, Lp(a) 1.51138
NANP N-acetylneuraminic acid phosphatase 1.49613
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 1.45641
CSNK1A1 casein kinase 1, alpha 1 1.45471
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.44768
LDLR low density lipoprotein receptor 1.4399
HSP90AA6P heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene 1.43592
HELQ helicase, POLQ-like 1.42467
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 1.42111
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.39396
MAP1A microtubule-associated protein 1A 1.35898
CA11 carbonic anhydrase XI 1.35121
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 1.34633
TP53BP1 tumor protein p53 binding protein 1 1.33817
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 1.31635
OCA2 oculocutaneous albinism II 1.3155
TMC1 transmembrane channel-like 1 1.31297
MTAP methylthioadenosine phosphorylase 1.30814
PEBP4 phosphatidylethanolamine-binding protein 4 1.29944
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.29323
FKBP1A FK506 binding protein 1A, 12kDa 1.28862
MCC mutated in colorectal cancers 1.28755
KANK1 KN motif and ankyrin repeat domains 1 1.28205
CLN3 ceroid-lipofuscinosis, neuronal 3 1.27884
WWOX WW domain containing oxidoreductase 1.27529
SREBF2 sterol regulatory element binding transcription factor 2 1.27473
DGKH diacylglycerol kinase, eta 1.27275
TFDP1 transcription factor Dp-1 1.27154
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 1.26953
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.26366
MUC1 mucin 1, cell surface associated 1.25477
TSPAN11 tetraspanin 11 1.23909
ZFAND5 zinc finger, AN1-type domain 5 1.23875
CCDC101 coiled-coil domain containing 101 1.23691
TEX41 testis expressed 41 (non-protein coding) 1.2346
FAM167A family with sequence similarity 167, member A 1.23283
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 1.22979
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.21975
IL18R1 interleukin 18 receptor 1 1.21382
JAZF1 JAZF zinc finger 1 1.21296
AMPH amphiphysin 1.21184
TBL2 transducin (beta)-like 2 1.2101
TRPC4 transient receptor potential cation channel, subfamily C, member 4 1.20938
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.20178
AGBL4 ATP/GTP binding protein-like 4 1.20031
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 1.18285
PTPRM protein tyrosine phosphatase, receptor type, M 1.18117
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.18117
ATF1 activating transcription factor 1 1.17101
POSTN periostin, osteoblast specific factor 1.16218
USP18 ubiquitin specific peptidase 18 1.15841
DOCK9 dedicator of cytokinesis 9 1.15602
JAZF1-AS1 JAZF1 antisense RNA 1 1.15381
RBMS3 RNA binding motif, single stranded interacting protein 3 1.14463
AXDND1 axonemal dynein light chain domain containing 1 1.13617
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.13207
ATXN2L ataxin 2-like 1.12701
SPNS1 spinster homolog 1 (Drosophila) 1.11309
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.11309
LOC646762 uncharacterized LOC646762 1.10153
CADM2 cell adhesion molecule 2 1.1012
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.10023
THOC5 THO complex 5 1.09959
CLYBL citrate lyase beta like 1.09284
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.08934
IL1RAP interleukin 1 receptor accessory protein 1.08765
COL5A3 collagen, type V, alpha 3 1.07599
BCAT1 branched chain amino-acid transaminase 1, cytosolic 1.07393
DNAH11 dynein, axonemal, heavy chain 11 1.05823
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 1.04565
HCG18 HLA complex group 18 (non-protein coding) 1.03741
DOCK2 dedicator of cytokinesis 2 1.03112
ABHD6 abhydrolase domain containing 6 1.02921
KIAA0368 KIAA0368 1.02897
MSH5 mutS homolog 5 1.02476
OSMR oncostatin M receptor 1.0052
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.00039
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 0.986376
BPTF bromodomain PHD finger transcription factor 0.968253
ADH6 alcohol dehydrogenase 6 (class V) 0.93456
CCDC117 coiled-coil domain containing 117 0.93103
ESRRG estrogen-related receptor gamma 0.907791
TSC22D2 TSC22 domain family, member 2 0.90019
BDNF-AS BDNF antisense RNA 0.89953
FADS1 fatty acid desaturase 1 0.892579
PCDH7 protocadherin 7 0.887807
MTMR3 myotubularin related protein 3 0.863433
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.854796
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.854796
IL1RL1 interleukin 1 receptor-like 1 0.831584
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.738669
TMCC1 transmembrane and coiled-coil domain family 1 0.670054
FCRL5 Fc receptor-like 5 0.668836
C19ORF45 chromosome 19 open reading frame 45 0.668836
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.668836
OPRD1 opioid receptor, delta 1 0.564734
CRTC1 CREB regulated transcription coactivator 1 0.516381
BARX1 BARX homeobox 1 0.496271
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.49065
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.474717
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.468362
SLCO1B1 solute carrier organic anion transporter family, member 1B1 0.466852
PTPDC1 protein tyrosine phosphatase domain containing 1 0.465804
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.442803
SPARCL1 SPARC-like 1 (hevin) 0.422054
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.419335
APOC1 apolipoprotein C-I 0.416176
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 0.410113
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.395009
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.387239
FBXO11 F-box protein 11 0.385295
CETP cholesteryl ester transfer protein, plasma 0.383941
LECT1 leukocyte cell derived chemotaxin 1 0.378215
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.374496
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 0.363486
GRID1 glutamate receptor, ionotropic, delta 1 0.356365
OSBPL10 oxysterol binding protein-like 10 0.351977
DSG3 desmoglein 3 0.349005
ELP2 elongator acetyltransferase complex subunit 2 0.342736
FLJ45872 0.332037
AOX1 aldehyde oxidase 1 0.32949
OTX2-AS1 OTX2 antisense RNA 1 (head to head) 0.327326
RELN reelin 0.326362
MIR99AHG mir-99a-let-7c cluster host gene 0.321004