esculetin-7459 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the esculetin-7459 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM20 ADAM metallopeptidase domain 20
ADAM22 ADAM metallopeptidase domain 22
ADARB1 adenosine deaminase, RNA-specific, B1
ADRA1D adrenoceptor alpha 1D
ADTRP androgen-dependent TFPI-regulating protein
AQP3 aquaporin 3 (Gill blood group)
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARMC4 armadillo repeat containing 4
ART1 ADP-ribosyltransferase 1
ATP10B ATPase, class V, type 10B
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C1ORF61 chromosome 1 open reading frame 61
CALB2 calbindin 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CLCF1 cardiotrophin-like cytokine factor 1
CSPP1 centrosome and spindle pole associated protein 1
CTAGE5 CTAGE family, member 5
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYBB cytochrome b-245, beta polypeptide
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ECE1 endothelin converting enzyme 1
ERCC2 excision repair cross-complementation group 2
EWSR1 EWS RNA-binding protein 1
FADS3 fatty acid desaturase 3
FLJ42627 uncharacterized LOC645644
FOXG1 forkhead box G1
GLI1 GLI family zinc finger 1
GPR137 G protein-coupled receptor 137
GRTP1 growth hormone regulated TBC protein 1
GSTM4 glutathione S-transferase mu 4
HAUS5 HAUS augmin-like complex, subunit 5
HFE hemochromatosis
HIST1H1B histone cluster 1, H1b
HPX hemopexin
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS2 insulin receptor substrate 2
ITPK1 inositol-tetrakisphosphate 1-kinase
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD7 potassium channel tetramerization domain containing 7
KHSRP KH-type splicing regulatory protein
LAT2 linker for activation of T cells family, member 2
LHX2 LIM homeobox 2
LMAN1 lectin, mannose-binding, 1
LRP12 low density lipoprotein receptor-related protein 12
LRP5L low density lipoprotein receptor-related protein 5-like
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP4 microtubule-associated protein 4
MAPK8 mitogen-activated protein kinase 8
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIER2 mesoderm induction early response 1, family member 2
MYL5 myosin, light chain 5, regulatory
NCAPH2 non-SMC condensin II complex, subunit H2
NCOR2 nuclear receptor corepressor 2
NF2 neurofibromin 2 (merlin)
NOP14-AS1 NOP14 antisense RNA 1
PAX2 paired box 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLAC1 placenta-specific 1
PLCD1 phospholipase C, delta 1
POLL polymerase (DNA directed), lambda
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSG11 pregnancy specific beta-1-glycoprotein 11
PTH1R parathyroid hormone 1 receptor
RAB33A RAB33A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIMS3 regulating synaptic membrane exocytosis 3
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPL18 ribosomal protein L18
RPL35A ribosomal protein L35a
S100A8 S100 calcium binding protein A8
SAPCD1 suppressor APC domain containing 1
SENP6 SUMO1/sentrin specific peptidase 6
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPN sialophorin
SPTBN1 spectrin, beta, non-erythrocytic 1
STAB2 stabilin 2
STIM1 stromal interaction molecule 1
STK11 serine/threonine kinase 11
SYNJ2 synaptojanin 2
THBS3 thrombospondin 3
TJAP1 tight junction associated protein 1 (peripheral)
TMEM97 transmembrane protein 97
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TTC38 tetratricopeptide repeat domain 38
TTLL5 tubulin tyrosine ligase-like family member 5
USP34 ubiquitin specific peptidase 34
WIZ widely interspaced zinc finger motifs
WNT2B wingless-type MMTV integration site family, member 2B
ZBTB17 zinc finger and BTB domain containing 17
ZC3H13 zinc finger CCCH-type containing 13

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
AGO3 argonaute RISC catalytic component 3
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD36 ankyrin repeat domain 36
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA1 annexin A1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMC7 armadillo repeat containing 7
ASRGL1 asparaginase like 1
AXIN1 axin 1
BACE1 beta-site APP-cleaving enzyme 1
BCAS1 breast carcinoma amplified sequence 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C7ORF43 chromosome 7 open reading frame 43
CCNL2 cyclin L2
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CGREF1 cell growth regulator with EF-hand domain 1
CIC capicua transcriptional repressor
CNKSR1 connector enhancer of kinase suppressor of Ras 1
DCAF13 DDB1 and CUL4 associated factor 13
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAL4 dynein, axonemal, light chain 4
EFHC1 EF-hand domain (C-terminal) containing 1
EPHA2 EPH receptor A2
FBXO31 F-box protein 31
FCHO1 FCH domain only 1
FKBP10 FK506 binding protein 10, 65 kDa
GALK1 galactokinase 1
GLB1L2 galactosidase, beta 1-like 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPX2 glutathione peroxidase 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AI histone cluster 1, H2ai
HIST1H4F histone cluster 1, H4f
HS1BP3 HCLS1 binding protein 3
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
KLHDC4 kelch domain containing 4
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC8E leucine rich repeat containing 8 family, member E
LYPD1 LY6/PLAUR domain containing 1
LYPLA2P1 lysophospholipase II pseudogene 1
MANBA mannosidase, beta A, lysosomal
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK12 mitogen-activated protein kinase 12
MGC12488
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MPI mannose phosphate isomerase
MPST mercaptopyruvate sulfurtransferase
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTRF1 mitochondrial translational release factor 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NECAB3 N-terminal EF-hand calcium binding protein 3
NT5DC3 5'-nucleotidase domain containing 3
NUAK1 NUAK family, SNF1-like kinase, 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDZRN3 PDZ domain containing ring finger 3
PGP phosphoglycolate phosphatase
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIBF1 progesterone immunomodulatory binding factor 1
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLA2G15 phospholipase A2, group XV
PLD2 phospholipase D2
PMM1 phosphomannomutase 1
PODXL2 podocalyxin-like 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTDSS2 phosphatidylserine synthase 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS19 regulator of G-protein signaling 19
RNF2 ring finger protein 2
RNF25 ring finger protein 25
RPAP1 RNA polymerase II associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RRP1 ribosomal RNA processing 1
SETD3 SET domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLC16A6 solute carrier family 16, member 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TEAD3 TEA domain family member 3
TMEM104 transmembrane protein 104
TTC33 tetratricopeptide repeat domain 33
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
VEGFC vascular endothelial growth factor C
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZNF248 zinc finger protein 248
ZNF8 zinc finger protein 8
ZSCAN9 zinc finger and SCAN domain containing 9