error-prone translesion synthesis Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. (Gene Ontology, GO_0042276)
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4 genes participating in the error-prone translesion synthesis biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
KIAA2022 KIAA2022
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit