erastin-6417 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the erastin-6417 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADCY6 adenylate cyclase 6
AKR1C1 aldo-keto reductase family 1, member C1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOL2 apolipoprotein L, 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB2 arrestin, beta 2
ATG2B autophagy related 2B
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAHCC1 BAH domain and coiled-coil containing 1
BAX BCL2-associated X protein
BBS7 Bardet-Biedl syndrome 7
CARD8 caspase recruitment domain family, member 8
CASZ1 castor zinc finger 1
CCNJL cyclin J-like
CCNO cyclin O
CCSER2 coiled-coil serine-rich protein 2
CD58 CD58 molecule
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSNK1E casein kinase 1, epsilon
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTSZ cathepsin Z
CYLD cylindromatosis (turban tumor syndrome)
DDIT4 DNA-damage-inducible transcript 4
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAL4 dynein, axonemal, light chain 4
EML2 echinoderm microtubule associated protein like 2
EMP1 epithelial membrane protein 1
ETV1 ets variant 1
FAM214B family with sequence similarity 214, member B
FANCF Fanconi anemia, complementation group F
FGFR1 fibroblast growth factor receptor 1
FLJ11710 uncharacterized protein FLJ11710
FURIN furin (paired basic amino acid cleaving enzyme)
GK glycerol kinase
GOSR2 golgi SNAP receptor complex member 2
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFT122 intraflagellar transport 122
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
IQCE IQ motif containing E
KIFC1 kinesin family member C1
KLHL20 kelch-like family member 20
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LARP6 La ribonucleoprotein domain family, member 6
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEH1 melanoma antigen family H1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK14 mitogen-activated protein kinase 14
MARS methionyl-tRNA synthetase
MCM3AP minichromosome maintenance complex component 3 associated protein
MFSD6 major facilitator superfamily domain containing 6
NDE1 nudE neurodevelopment protein 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PFDN6 prefoldin subunit 6
PGPEP1 pyroglutamyl-peptidase I
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PISD phosphatidylserine decarboxylase
PKP1 plakophilin 1
POMT2 protein-O-mannosyltransferase 2
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRPH peripherin
PTGFR prostaglandin F receptor (FP)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB17 RAB17, member RAS oncogene family
RANGAP1 Ran GTPase activating protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
SAPCD1 suppressor APC domain containing 1
SFTPB surfactant protein B
SGSM2 small G protein signaling modulator 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNAP23 synaptosomal-associated protein, 23kDa
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STC1 stanniocalcin 1
STON1 stonin 1
SYT1 synaptotagmin I
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
THBD thrombomodulin
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM259 transmembrane protein 259
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRIB3 tribbles pseudokinase 3
TUBGCP2 tubulin, gamma complex associated protein 2
WSB1 WD repeat and SOCS box containing 1
YPEL1 yippee-like 1 (Drosophila)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB20 zinc finger and BTB domain containing 20
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAP2 ArfGAP with dual PH domains 2
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANP32A-IT1 ANP32A intronic transcript 1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARMCX4 armadillo repeat containing, X-linked 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C3AR1 complement component 3a receptor 1
C4ORF29 chromosome 4 open reading frame 29
C5ORF42 chromosome 5 open reading frame 42
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CENPQ centromere protein Q
CHAT choline O-acetyltransferase
CRY2 cryptochrome circadian clock 2
DDN dendrin
EGF epidermal growth factor
FAM50B family with sequence similarity 50, member B
FRMD1 FERM domain containing 1
FSD1 fibronectin type III and SPRY domain containing 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GBP2 guanylate binding protein 2, interferon-inducible
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRTP1 growth hormone regulated TBC protein 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMB major histocompatibility complex, class II, DM beta
HOOK1 hook microtubule-tethering protein 1
HOXA6 homeobox A6
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSF2BP heat shock transcription factor 2 binding protein
HYAL3 hyaluronoglucosaminidase 3
IL20RA interleukin 20 receptor, alpha
INHBB inhibin, beta B
KIAA1456 KIAA1456
KLC2 kinesin light chain 2
KLHL36 kelch-like family member 36
LOC100127972 uncharacterized LOC100127972
LOC100286895 cell division cycle 27 homolog pseudogene
MMP10 matrix metallopeptidase 10
MMP2 matrix metallopeptidase 2
MON1B MON1 secretory trafficking family member B
NECAB3 N-terminal EF-hand calcium binding protein 3
NELL2 NEL-like 2 (chicken)
NOD1 nucleotide-binding oligomerization domain containing 1
NPFFR1 neuropeptide FF receptor 1
NRTN neurturin
ODF1 outer dense fiber of sperm tails 1
OSBP2 oxysterol binding protein 2
PADI1 peptidyl arginine deiminase, type I
PER3 period circadian clock 3
PLXNA3 plexin A3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLH polymerase (DNA directed), eta
PRAMEF11 PRAME family member 11
PRMT7 protein arginine methyltransferase 7
RAB3A RAB3A, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RETN resistin
RHOBTB2 Rho-related BTB domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SAYSD1 SAYSVFN motif domain containing 1
SETD6 SET domain containing 6
SIRT6 sirtuin 6
SIX3 SIX homeobox 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SMCP sperm mitochondria-associated cysteine-rich protein
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX12 SRY (sex determining region Y)-box 12
STAG3 stromal antigen 3
SULT4A1 sulfotransferase family 4A, member 1
TAOK1 TAO kinase 1
TBXAS1 thromboxane A synthase 1 (platelet)
TEAD3 TEA domain family member 3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TMEM212 transmembrane protein 212
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF2 TNF receptor-associated factor 2
TRAPPC13 trafficking protein particle complex 13
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VASP vasodilator-stimulated phosphoprotein
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR18 WD repeat domain 18
WNT7A wingless-type MMTV integration site family, member 7A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF107 zinc finger protein 107
ZNF155 zinc finger protein 155
ZNF408 zinc finger protein 408
ZNF862 zinc finger protein 862