erastin-6412 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the erastin-6412 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMPH amphiphysin
ANGPT4 angiopoietin 4
APOL3 apolipoprotein L, 3
APP amyloid beta (A4) precursor protein
ARMC4 armadillo repeat containing 4
ARMCX4 armadillo repeat containing, X-linked 4
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C11ORF21 chromosome 11 open reading frame 21
C14ORF1 chromosome 14 open reading frame 1
C7ORF69 chromosome 7 open reading frame 69
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASC1 cancer susceptibility candidate 1
CAV2 caveolin 2
CCR8 chemokine (C-C motif) receptor 8
CDK13 cyclin-dependent kinase 13
CENPO centromere protein O
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLSTN3 calsyntenin 3
COL16A1 collagen, type XVI, alpha 1
COLEC12 collectin sub-family member 12
CXORF21 chromosome X open reading frame 21
DDIT3 DNA-damage-inducible transcript 3
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EPHA3 EPH receptor A3
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
FH fumarate hydratase
FNDC3A fibronectin type III domain containing 3A
FOSL2 FOS-like antigen 2
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GAP43 growth associated protein 43
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIPK3 homeodomain interacting protein kinase 3
HIST1H1B histone cluster 1, H1b
HIST1H2BN histone cluster 1, H2bn
HIST1H4D histone cluster 1, H4d
IFNA14 interferon, alpha 14
INHBE inhibin, beta E
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCTD17 potassium channel tetramerization domain containing 17
KIAA1661 KIAA1661 protein
KRTAP1-1 keratin associated protein 1-1
LARP7 La ribonucleoprotein domain family, member 7
MATN1 matrilin 1, cartilage matrix protein
MIER2 mesoderm induction early response 1, family member 2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSL3 male-specific lethal 3 homolog (Drosophila)
MYF5 myogenic factor 5
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NOVA2 neuro-oncological ventral antigen 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OSBPL10 oxysterol binding protein-like 10
PCDHB6 protocadherin beta 6
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLEK pleckstrin
PLIN2 perilipin 2
PLK3 polo-like kinase 3
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
PRKCB protein kinase C, beta
PRTN3 proteinase 3
PTCH1 patched 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RBFA ribosome binding factor A (putative)
RDH16 retinol dehydrogenase 16 (all-trans)
RNF126P1 ring finger protein 126 pseudogene 1
RYR2 ryanodine receptor 2 (cardiac)
S100A8 S100 calcium binding protein A8
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SDS serine dehydratase
SH2D3A SH2 domain containing 3A
SIGLEC7 sialic acid binding Ig-like lectin 7
SIRT5 sirtuin 5
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLN sarcolipin
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRSF7 serine/arginine-rich splicing factor 7
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TTLL1 tubulin tyrosine ligase-like family member 1
VIPR2 vasoactive intestinal peptide receptor 2
ZNF528 zinc finger protein 528
ZNF695 zinc finger protein 695
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
AFAP1 actin filament associated protein 1
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
AOC3 amine oxidase, copper containing 3
ARC activity-regulated cytoskeleton-associated protein
ARHGAP24 Rho GTPase activating protein 24
ASIC2 acid sensing (proton gated) ion channel 2
BEGAIN brain-enriched guanylate kinase-associated
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C1ORF21 chromosome 1 open reading frame 21
C3ORF18 chromosome 3 open reading frame 18
CCDC9 coiled-coil domain containing 9
CD14 CD14 molecule
CLEC4E C-type lectin domain family 4, member E
CSTA cystatin A (stefin A)
CT62 cancer/testis antigen 62
DGAT1 diacylglycerol O-acyltransferase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNA3 ephrin-A3
ELL elongation factor RNA polymerase II
EPPK1 epiplakin 1
ESM1 endothelial cell-specific molecule 1
FAM46C family with sequence similarity 46, member C
FAM76A family with sequence similarity 76, member A
FLT4 fms-related tyrosine kinase 4
FSHB follicle stimulating hormone, beta polypeptide
FXYD5 FXYD domain containing ion transport regulator 5
GLB1L galactosidase, beta 1-like
GPR143 G protein-coupled receptor 143
GPR15 G protein-coupled receptor 15
GRIP2 glutamate receptor interacting protein 2
HDAC5 histone deacetylase 5
HEXA-AS1 HEXA antisense RNA 1
HIST1H3A histone cluster 1, H3a
HOXB2 homeobox B2
HOXB3 homeobox B3
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNIP2 Kv channel interacting protein 2
KIAA1456 KIAA1456
KLHL28 kelch-like family member 28
LDB2 LIM domain binding 2
LHX1 LIM homeobox 1
LPAR4 lysophosphatidic acid receptor 4
LSP1 lymphocyte-specific protein 1
MAPK10 mitogen-activated protein kinase 10
MBTD1 mbt domain containing 1
MDFI MyoD family inhibitor
MIP major intrinsic protein of lens fiber
MIR600HG MIR600 host gene
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MS4A5 membrane-spanning 4-domains, subfamily A, member 5
NECAB2 N-terminal EF-hand calcium binding protein 2
NME5 NME/NM23 family member 5
NRL neural retina leucine zipper
ONECUT2 one cut homeobox 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALM paralemmin
PCBP3 poly(rC) binding protein 3
PCDHGA11 protocadherin gamma subfamily A, 11
PCDHGA9 protocadherin gamma subfamily A, 9
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
POU3F4 POU class 3 homeobox 4
PRDM12 PR domain containing 12
PROM1 prominin 1
PRSS53 protease, serine, 53
QPCT glutaminyl-peptide cyclotransferase
RAD54L2 RAD54-like 2 (S. cerevisiae)
RETN resistin
RNF122 ring finger protein 122
SCG5 secretogranin V
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SNTG1 syntrophin, gamma 1
SNX29 sorting nexin 29
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TCTN2 tectonic family member 2
TDRD12 tudor domain containing 12
TLR2 toll-like receptor 2
TMEM53 transmembrane protein 53
TMEM8B transmembrane protein 8B
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TTPA tocopherol (alpha) transfer protein
TUBB1 tubulin, beta 1 class VI
VIPR1 vasoactive intestinal peptide receptor 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WNT8B wingless-type MMTV integration site family, member 8B
XDH xanthine dehydrogenase
ZNF112 zinc finger protein 112
ZNF613 zinc finger protein 613