epiphyseal growth plate Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The disk or plate of cartilage interposed between the epiphysis and the shaft of the bone during the period of growth; by its growth the bone increases in length. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000412)
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Genes

248 proteins co-occuring with the tissue epiphyseal growth plate in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
IHH indian hedgehog 2.20191
ACAN aggrecan 1.83528
PTHLH parathyroid hormone-like hormone 1.78942
ALPL alkaline phosphatase, liver/bone/kidney 1.76676
ALPPL2 alkaline phosphatase, placental-like 2 1.75824
ALPP alkaline phosphatase, placental 1.75624
IGF1 insulin-like growth factor 1 (somatomedin C) 1.73081
FGFR3 fibroblast growth factor receptor 3 1.63906
COL2A1 collagen, type II, alpha 1 1.62507
EXT2 exostosin glycosyltransferase 2 1.5888
PTH parathyroid hormone 1.55746
RUNX2 runt-related transcription factor 2 1.55503
LECT1 leukocyte cell derived chemotaxin 1 1.55406
EXT1 exostosin glycosyltransferase 1 1.47195
COL10A1 collagen, type X, alpha 1 1.44033
EPYC epiphycan 1.43015
MSLNL mesothelin-like 1.39467
SHOX short stature homeobox 1.33681
MATN1 matrilin 1, cartilage matrix protein 1.23182
MMP13 matrix metallopeptidase 13 1.2238
SOX5 SRY (sex determining region Y)-box 5 1.19934
SOX6 SRY (sex determining region Y)-box 6 1.09916
CRELD2 cysteine-rich with EGF-like domains 2 1.07221
MATN3 matrilin 3 1.07132
SOX9 SRY (sex determining region Y)-box 9 1.06823
BMP2 bone morphogenetic protein 2 1.03127
COMP cartilage oligomeric matrix protein 1.02075
XPO4 exportin 4 0.998473
PTH1R parathyroid hormone 1 receptor 0.98977
ACPP acid phosphatase, prostate 0.974149
TRPS1 trichorhinophalangeal syndrome I 0.968955
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.937059
GLI2 GLI family zinc finger 2 0.933195
USO1 USO1 vesicle transport factor 0.927192
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.916069
SPP1 secreted phosphoprotein 1 0.915642
OSBPL6 oxysterol binding protein-like 6 0.89477
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.882474
FGF2 fibroblast growth factor 2 (basic) 0.880781
FGFR2 fibroblast growth factor receptor 2 0.876552
PPA1 pyrophosphatase (inorganic) 1 0.871905
BGN biglycan 0.871905
TGFB1 transforming growth factor, beta 1 0.867263
BGLAP bone gamma-carboxyglutamate (gla) protein 0.86642
COL11A2 collagen, type XI, alpha 2 0.842027
FMOD fibromodulin 0.830291
GDF5 growth differentiation factor 5 0.824849
HEBP1 heme binding protein 1 0.812309
PTCH1 patched 1 0.801042
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.797708
SP7 Sp7 transcription factor 0.772344
UXS1 UDP-glucuronate decarboxylase 1 0.762811
GHR growth hormone receptor 0.762397
ESR1 estrogen receptor 1 0.754124
DCN decorin 0.752884
PCNA proliferating cell nuclear antigen 0.747515
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.742564
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.74009
CTGF connective tissue growth factor 0.728975
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.719934
THRB thyroid hormone receptor, beta 0.717061
COL13A1 collagen, type XIII, alpha 1 0.707631
MMP9 matrix metallopeptidase 9 0.706812
MEX3C mex-3 RNA binding family member C 0.706812
SDC3 syndecan 3 0.704355
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.695354
IGF1R insulin-like growth factor 1 receptor 0.688817
RPL31 ribosomal protein L31 0.688409
NKX3-2 NK3 homeobox 2 0.678617
EVC Ellis van Creveld protein 0.676172
FGF1 fibroblast growth factor 1 (acidic) 0.672913
COL9A1 collagen, type IX, alpha 1 0.670878
OGN osteoglycin 0.66925
WNT9A wingless-type MMTV integration site family, member 9A 0.662742
IGFBP3 insulin-like growth factor binding protein 3 0.66071
ATOH8 atonal homolog 8 (Drosophila) 0.656648
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.653807
GLI1 GLI family zinc finger 1 0.648938
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.648127
RUNX3 runt-related transcription factor 3 0.63638
AES amino-terminal enhancer of split 0.634358
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.631527
TRAPPC2 trafficking protein particle complex 2 0.626273
MGP matrix Gla protein 0.626273
BCO1 beta-carotene oxygenase 1 0.614974
PRKG2 protein kinase, cGMP-dependent, type II 0.604502
CHAD chondroadherin 0.598871
IFT88 intraflagellar transport 88 0.597263
IVD isovaleryl-CoA dehydrogenase 0.590839
BMP6 bone morphogenetic protein 6 0.582019
ACP5 acid phosphatase 5, tartrate resistant 0.563637
GLI3 GLI family zinc finger 3 0.559652
DSEL dermatan sulfate epimerase-like 0.559254
EXTL2 exostosin-like glycosyltransferase 2 0.557263
CCND1 cyclin D1 0.551695
HHIP hedgehog interacting protein 0.549312
NTPCR nucleoside-triphosphatase, cancer-related 0.547326
INS insulin 0.546929
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.544946
GSAP gamma-secretase activating protein 0.541377
SIK3 SIK family kinase 3 0.528323
IGFBP1 insulin-like growth factor binding protein 1 0.527534
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.527139
VEGFA vascular endothelial growth factor A 0.520041
EXTL1 exostosin-like glycosyltransferase 1 0.516497
CHKB choline kinase beta 0.516104
MATN4 matrilin 4 0.51453
FGF23 fibroblast growth factor 23 0.510992
GH1 growth hormone 1 0.50079
IBSP integrin-binding sialoprotein 0.499223
S100G S100 calcium binding protein G 0.49844
CALCA calcitonin-related polypeptide alpha 0.498048
ATF2 activating transcription factor 2 0.496483
LEP leptin 0.494528
SMAD5 SMAD family member 5 0.491791
TNS3 tensin 3 0.491009
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.483596
PAX1 paired box 1 0.483596
FRZB frizzled-related protein 0.483206
MANF mesencephalic astrocyte-derived neurotrophic factor 0.477756
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.471539
RASIP1 Ras interacting protein 1 0.470763
IGFBP5 insulin-like growth factor binding protein 5 0.469211
TAOK1 TAO kinase 1 0.465335
SIX5 SIX homeobox 5 0.449886
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.449116
GALNS galactosamine (N-acetyl)-6-sulfatase 0.448731
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.448731
C4BPA complement component 4 binding protein, alpha 0.447961
GPC6 glypican 6 0.446038
TIMP1 TIMP metallopeptidase inhibitor 1 0.441042
DGKB diacylglycerol kinase, beta 90kDa 0.440658
MGAM maltase-glucoamylase 0.438739
FGF9 fibroblast growth factor 9 0.437205
LYZ lysozyme 0.436438
FGFR1 fibroblast growth factor receptor 1 0.432608
GPANK1 G patch domain and ankyrin repeats 1 0.432225
C11ORF58 chromosome 11 open reading frame 58 0.43146
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.43146
MMP3 matrix metallopeptidase 3 0.430312
NPHP3 nephronophthisis 3 (adolescent) 0.429165
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.425344
EBP emopamil binding protein (sterol isomerase) 0.424581
SIX4 SIX homeobox 4 0.422292
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.419623
FGF22 fibroblast growth factor 22 0.418861
MEPE matrix extracellular phosphoglycoprotein 0.417337
HOXC10 homeobox C10 0.411251
NPPC natriuretic peptide C 0.407453
DEFB105B defensin, beta 105B 0.406694
POU6F2 POU class 6 homeobox 2 0.406315
DNAH8 dynein, axonemal, heavy chain 8 0.404797
ARSB arylsulfatase B 0.401007
RUNX1 runt-related transcription factor 1 0.400628
HAS2 hyaluronan synthase 2 0.397222
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.391553
IGF2 insulin-like growth factor 2 0.389666
PLLP plasmolipin 0.387027
PRICKLE1 prickle homolog 1 (Drosophila) 0.385896
SMAD6 SMAD family member 6 0.380627
TNC tenascin C 0.377621
TNNI2 troponin I type 2 (skeletal, fast) 0.377245
HOXD13 homeobox D13 0.376494
BMP7 bone morphogenetic protein 7 0.374993
HOXD1 homeobox D1 0.373493
LOXL4 lysyl oxidase-like 4 0.37087
EXTL3 exostosin-like glycosyltransferase 3 0.364886
PRELP proline/arginine-rich end leucine-rich repeat protein 0.364513
MEF2C myocyte enhancer factor 2C 0.363766
TDP1 tyrosyl-DNA phosphodiesterase 1 0.362646
COL9A3 collagen, type IX, alpha 3 0.357802
MMP11 matrix metallopeptidase 11 0.35743
PNMA2 paraneoplastic Ma antigen 2 0.357058
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.356686
PLAC8 placenta-specific 8 0.35557
EMCN endomucin 0.352969
ANXA8 annexin A8 0.34926
FGF18 fibroblast growth factor 18 0.348519
MATN2 matrilin 2 0.347038
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.342971
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.339282
CTSK cathepsin K 0.339282
BMP3 bone morphogenetic protein 3 0.337808
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.330094
TGFB3 transforming growth factor, beta 3 0.327164
ESR2 estrogen receptor 2 (ER beta) 0.326432
PLCE1 phospholipase C, epsilon 1 0.323509
KLF5 Kruppel-like factor 5 (intestinal) 0.323509
BMP1 bone morphogenetic protein 1 0.322779
HBA1 hemoglobin, alpha 1 0.322779
GPC4 glypican 4 0.320227
ANGPTL7 angiopoietin-like 7 0.318407
TST thiosulfate sulfurtransferase (rhodanese) 0.318407
PRSS58 protease, serine, 58 0.315861
SHOX2 short stature homeobox 2 0.314046
FGFRL1 fibroblast growth factor receptor-like 1 0.31187
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.31187
HBA2 hemoglobin, alpha 2 0.310783
CFL1 cofilin 1 (non-muscle) 0.306805
FN1 fibronectin 1 0.305361
PHEX phosphate regulating endopeptidase homolog, X-linked 0.303919
FGF13 fibroblast growth factor 13 0.297806
STAG2 stromal antigen 2 0.295297
THBS3 thrombospondin 3 0.294939
DNTT DNA nucleotidylexotransferase 0.292793
CAMK1 calcium/calmodulin-dependent protein kinase I 0.292436
MMP2 matrix metallopeptidase 2 0.287803
TGFBR1 transforming growth factor, beta receptor 1 0.287092
FLT1 fms-related tyrosine kinase 1 0.284962
NELL2 NEL-like 2 (chicken) 0.283899
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.280364
PDE11A phosphodiesterase 11A 0.279659
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.277197
FAM120A family with sequence similarity 120A 0.276846
RXRG retinoid X receptor, gamma 0.276145
NOV nephroblastoma overexpressed 0.274744
NPR2 natriuretic peptide receptor 2 0.270214
IGFBP6 insulin-like growth factor binding protein 6 0.269174
PLAA phospholipase A2-activating protein 0.266413
HTRA1 HtrA serine peptidase 1 0.263669
FGF4 fibroblast growth factor 4 0.263327
FOSL2 FOS-like antigen 2 0.263327
HDAC4 histone deacetylase 4 0.261964
AVIL advillin 0.260945
GDF7 growth differentiation factor 7 0.254902
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.253908
LECT2 leukocyte cell-derived chemotaxin 2 0.253908
LOX lysyl oxidase 0.253248
INHBB inhibin, beta B 0.251279
FOXA3 forkhead box A3 0.250627
HOXD4 homeobox D4 0.250627
CARS cysteinyl-tRNA synthetase 0.243294
COL1A1 collagen, type I, alpha 1 0.242672
CALU calumenin 0.241746
FGF21 fibroblast growth factor 21 0.23961
STAT1 signal transducer and activator of transcription 1, 91kDa 0.23961
STAT5B signal transducer and activator of transcription 5B 0.237513
TPR translocated promoter region, nuclear basket protein 0.236921
ATF5 activating transcription factor 5 0.236921
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 0.235167
SCGB2A1 secretoglobin, family 2A, member 1 0.234016
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.233162
FGFBP1 fibroblast growth factor binding protein 1 0.225395
KLF15 Kruppel-like factor 15 0.22246
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.22246
CYTIP cytohesin 1 interacting protein 0.221755
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.221755
SRY sex determining region Y 0.217346