enteric nervous system Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002506)
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Genes

199 proteins co-occuring with the tissue enteric nervous system in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
RET ret proto-oncogene 2.29145
GDNF glial cell derived neurotrophic factor 2.23788
SOX10 SRY (sex determining region Y)-box 10 2.10112
EDNRB endothelin receptor type B 2.09791
VIP vasoactive intestinal peptide 2.00385
TAC1 tachykinin, precursor 1 1.9525
EDN3 endothelin 3 1.79195
ELAVL3 ELAV like neuron-specific RNA binding protein 3 1.67706
CHAT choline O-acetyltransferase 1.62907
NRTN neurturin 1.62357
NPS neuropeptide S 1.51285
CALB2 calbindin 2 1.49773
CALB1 calbindin 1, 28kDa 1.46915
CALCA calcitonin-related polypeptide alpha 1.46588
GFRA1 GDNF family receptor alpha 1 1.43801
NPY neuropeptide Y 1.41261
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.3933
SST somatostatin 1.2149
PRNP prion protein 1.20734
ENO2 enolase 2 (gamma, neuronal) 1.20511
CCK cholecystokinin 1.19267
TH tyrosine hydroxylase 1.19089
GAL galanin/GMAP prepropeptide 1.18645
NTF3 neurotrophin 3 1.15628
ARTN artemin 1.15318
PSPN persephin 1.14476
B3GAT1 beta-1,3-glucuronyltransferase 1 1.08015
PYY peptide YY 1.07618
MLN motilin 1.07441
NTS neurotensin 1.06382
RASGEF1A RasGEF domain family, member 1A 1.06074
GRP gastrin-releasing peptide 1.05589
ACHE acetylcholinesterase (Yt blood group) 1.0484
HOXB5 homeobox B5 1.02644
SYP synaptophysin 0.971119
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.955134
GHRL ghrelin/obestatin prepropeptide 0.93577
HOXA4 homeobox A4 0.890525
MRGPRF MAS-related GPR, member F 0.88671
GFAP glial fibrillary acidic protein 0.831547
HAND2 heart and neural crest derivatives expressed 2 0.811056
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.806465
GNG3 guanine nucleotide binding protein (G protein), gamma 3 0.783972
GAST gastrin 0.783557
TACR3 tachykinin receptor 3 0.781478
GHSR growth hormone secretagogue receptor 0.76364
KIF1BP KIF1 binding protein 0.761984
NGF nerve growth factor (beta polypeptide) 0.756604
CLDN11 claudin 11 0.753297
TMEM100 transmembrane protein 100 0.752884
MRGPRE MAS-related GPR, member E 0.750405
NGFR nerve growth factor receptor 0.743389
SORBS2 sorbin and SH3 domain containing 2 0.743389
TACR1 tachykinin receptor 1 0.742976
PPY pancreatic polypeptide 0.742976
HCRTR1 hypocretin (orexin) receptor 1 0.742976
CARTPT CART prepropeptide 0.737618
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.729385
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.719934
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.717061
FOS FBJ murine osteosarcoma viral oncogene homolog 0.717061
IGLV1-51 immunoglobulin lambda variable 1-51 0.711729
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.700262
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.697399
PHACTR4 phosphatase and actin regulator 4 0.687592
CNR1 cannabinoid receptor 1 (brain) 0.687184
NRG1 neuregulin 1 0.68188
DOK6 docking protein 6 0.681471
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.670471
S100B S100 calcium binding protein B 0.656648
MYO5A myosin VA (heavy chain 12, myoxin) 0.644884
PROKR1 prokineticin receptor 1 0.642048
PDYN prodynorphin 0.640428
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.634762
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.630718
BDNF brain-derived neurotrophic factor 0.621831
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.605709
SPAG7 sperm associated antigen 7 0.603697
GCG glucagon 0.599273
ZEB2 zinc finger E-box binding homeobox 2 0.592845
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.584422
NTNG1 netrin G1 0.561644
NES nestin 0.557263
SOX8 SRY (sex determining region Y)-box 8 0.556865
ASCL1 achaete-scute family bHLH transcription factor 1 0.550106
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.548517
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.547326
ECE1 endothelin converting enzyme 1 0.538209
ASIC3 acid sensing (proton gated) ion channel 3 0.534251
TPH1 tryptophan hydroxylase 1 0.527928
HCRT hypocretin (orexin) neuropeptide precursor 0.523982
PAX3 paired box 3 0.518072
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.513743
HMOX2 heme oxygenase 2 0.509027
GFRA3 GDNF family receptor alpha 3 0.496092
TACR2 tachykinin receptor 2 0.488276
PHOX2A paired-like homeobox 2a 0.485156
NMU neuromedin U 0.48087
NTF4 neurotrophin 4 0.477756
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.471539
NALCN sodium leak channel, non selective 0.469599
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.469211
CRH corticotropin releasing hormone 0.468436
HOXA13 homeobox A13 0.465335
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.464561
DOK4 docking protein 4 0.463013
RGMB repulsive guidance molecule family member b 0.459918
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.445268
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.439123
SHARPIN SHANK-associated RH domain interactor 0.436055
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.430695
NOS1 nitric oxide synthase 1 (neuronal) 0.426872
GPBAR1 G protein-coupled bile acid receptor 1 0.412771
BMP4 bone morphogenetic protein 4 0.410491
NTNG2 netrin G2 0.405555
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.404797
NOG noggin 0.401765
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.393442
INA internexin neuronal intermediate filament protein, alpha 0.392309
NEO1 neogenin 1 0.390421
IQGAP2 IQ motif containing GTPase activating protein 2 0.383637
NCAM1 neural cell adhesion molecule 1 0.377245
L1CAM L1 cell adhesion molecule 0.374618
ABAT 4-aminobutyrate aminotransferase 0.371245
PBX3 pre-B-cell leukemia homeobox 3 0.368624
POFUT1 protein O-fucosyltransferase 1 0.36825
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.362273
MYLK myosin light chain kinase 0.357058
SCN2A sodium channel, voltage gated, type II alpha subunit 0.357058
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.356686
MYLK3 myosin light chain kinase 3 0.350001
WNT1 wingless-type MMTV integration site family, member 1 0.347778
NTN1 netrin 1 0.347408
HOXB7 homeobox B7 0.345558
CRYGD crystallin, gamma D 0.345558
IL1B interleukin 1, beta 0.344818
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.34371
MAP2 microtubule-associated protein 2 0.341126
CHD3 chromodomain helicase DNA binding protein 3 0.329727
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.325335
BMP2 bone morphogenetic protein 2 0.320227
FOXD3 forkhead box D3 0.308974
TOM1 target of myb1 (chicken) 0.307528
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.302838
RNF115 ring finger protein 115 0.301758
EDN2 endothelin 2 0.301398
OPHN1 oligophrenin 1 0.301398
TRAPPC9 trafficking protein particle complex 9 0.298524
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.29673
ELSPBP1 epididymal sperm binding protein 1 0.29673
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.292436
SHH sonic hedgehog 0.28887
MYLIP myosin regulatory light chain interacting protein 0.288158
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.286736
CNTF ciliary neurotrophic factor 0.286381
HIPK2 homeodomain interacting protein kinase 2 0.285671
MARK3 MAP/microtubule affinity-regulating kinase 3 0.284253
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.281423
UCN urocortin 0.280717
STX1A syntaxin 1A (brain) 0.280364
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.279307
HOXD9 homeobox D9 0.277549
BDKRB1 bradykinin receptor B1 0.274744
CHGA chromogranin A 0.271952
PBX2 pre-B-cell leukemia homeobox 2 0.268137
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.264353
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.262986
NRG3 neuregulin 3 0.259929
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 0.257572
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.253248
MNX1 motor neuron and pancreas homeobox 1 0.251934
BMP10 bone morphogenetic protein 10 0.249653
AQP1 aquaporin 1 (Colton blood group) 0.249006
DPYS dihydropyrimidinase 0.247719
PROS1 protein S (alpha) 0.245175
KNG1 kininogen 1 0.245175
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.241746
RGMA repulsive guidance molecule family member a 0.241746
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.240826
ANO1 anoctamin 1, calcium activated chloride channel 0.239913
CCKAR cholecystokinin A receptor 0.23961
OPRL1 opiate receptor-like 1 0.239007
HLX H2.0-like homeobox 0.236332
HOXB8 homeobox B8 0.232881
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.232881
PTK7 protein tyrosine kinase 7 (inactive) 0.232317
BBS2 Bardet-Biedl syndrome 2 0.230382
KCNIP4 Kv channel interacting protein 4 0.227445
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.2259
HOXB9 homeobox B9 0.225144
GLP2R glucagon-like peptide 2 receptor 0.223906
SPON1 spondin 1, extracellular matrix protein 0.223906
INS insulin 0.221755
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.219485
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.215928
WTIP Wilms tumor 1 interacting protein 0.215341
MME membrane metallo-endopeptidase 0.215147
STX1B syntaxin 1B 0.213112
GAP43 growth associated protein 43 0.212413