endocrine system disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. (Human Disease Ontology, DOID_28)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:28
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Genes

229 genes associated with the disease endocrine system disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
PDE8B phosphodiesterase 8B 1.58296
DIO1 deiodinase, iodothyronine, type I 1.01258
PDE10A phosphodiesterase 10A 0.668836
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 0.492075
FGF7 fibroblast growth factor 7 0.485839
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.47048
PRDM11 PR domain containing 11 0.469622
ZNF789 zinc finger protein 789 0.468982
ZNF655 zinc finger protein 655 0.467179
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.465696
LHX3 LIM homeobox 3 0.459305
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.451436
ADAM32 ADAM metallopeptidase domain 32 0.449115
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.4409
TSHR thyroid stimulating hormone receptor 0.432715
NFIA nuclear factor I/A 0.429018
C6ORF10 chromosome 6 open reading frame 10 0.422809
MORC4 MORC family CW-type zinc finger 4 0.422809
CLDN2 claudin 2 0.413851
ZCWPW1 zinc finger, CW type with PWWP domain 1 0.41052
PVRIG poliovirus receptor related immunoglobulin domain containing 0.408577
INSR insulin receptor 0.40191
MPDU1 mannose-P-dolichol utilization defect 1 0.395081
TMEM196 transmembrane protein 196 0.394391
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.394076
CAPZB capping protein (actin filament) muscle Z-line, beta 0.389211
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.389052
SLAMF6 SLAM family member 6 0.388963
FAM200A family with sequence similarity 200, member A 0.383949
NRG1 neuregulin 1 0.382185
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 0.381826
PTCD1 pentatricopeptide repeat domain 1 0.379253
MYO16 myosin XVI 0.379084
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.372437
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.371363
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.367348
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.365108
GLIS3 GLIS family zinc finger 3 0.360052
HLA-J major histocompatibility complex, class I, J (pseudogene) 0.356114
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.354926
TCF19 transcription factor 19 0.347621
CCHCR1 coiled-coil alpha-helical rod protein 1 0.34026
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.334594
MUC22 mucin 22 0.334594
FCRL3 Fc receptor-like 3 0.330469
CFHR3 complement factor H-related 3 0.325033
ZMIZ1 zinc finger, MIZ-type containing 1 0.323243
SH2B3 SH2B adaptor protein 3 0.312949
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.31104
ATXN2 ataxin 2 0.309564
TMPRSS15 transmembrane protease, serine 15 0.305692
MCM7 minichromosome maintenance complex component 7 0.304742
TRIM4 tripartite motif containing 4 0.299233
ADAM23 ADAM metallopeptidase domain 23 0.298529
FGFR1OP FGFR1 oncogene partner 0.289197
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.287526
CRX cone-rod homeobox 0.283166
MOG myelin oligodendrocyte glycoprotein 0.28183
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.277733
CEP128 centrosomal protein 128kDa 0.274732
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.274227
VAV3 vav 3 guanine nucleotide exchange factor 0.268149
PILRB paired immunoglobin-like type 2 receptor beta 0.266496
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.266139
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.254482
CNTNAP2 contactin associated protein-like 2 0.254025
TG thyroglobulin 0.246141
REEP3 receptor accessory protein 3 0.243917
FCRL1 Fc receptor-like 1 0.242704
GRM5 glutamate receptor, metabotropic 5 0.236372
MINOS1 mitochondrial inner membrane organizing system 1 0.235928
CNTNAP5 contactin associated protein-like 5 0.233904
GYS1 glycogen synthase 1 (muscle) 0.230348
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.229911
ALCAM activated leukocyte cell adhesion molecule 0.228038
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.22547
TNF tumor necrosis factor 0.223161
NUP62 nucleoporin 62kDa 0.222297
IL1R2 interleukin 1 receptor, type II 0.221948
OLA1 Obg-like ATPase 1 0.217572
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.213809
NELFE negative elongation factor complex member E 0.211972
SLA Src-like-adaptor 0.205544
GLDN gliomedin 0.20134
CES1 carboxylesterase 1 0.198075
FBXO15 F-box protein 15 0.19781
ADGB androglobin 0.197541
RNASET2 ribonuclease T2 0.197331
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast) 0.196434
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.192711
CD5L CD5 molecule-like 0.192192
HLA-B major histocompatibility complex, class I, B 0.191943
PTPRT protein tyrosine phosphatase, receptor type, T 0.190778
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.190242
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.190242
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.190242
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.187919
MAST4 microtubule associated serine/threonine kinase family member 4 0.187511
HSPA4L heat shock 70kDa protein 4-like 0.18693
C6ORF15 chromosome 6 open reading frame 15 0.186029
CCDC81 coiled-coil domain containing 81 0.185926
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 0.185757
NCKAP5 NCK-associated protein 5 0.183866
TTC21A tetratricopeptide repeat domain 21A 0.18381
IFNGR1 interferon gamma receptor 1 0.183064
FCRL2 Fc receptor-like 2 0.17964
CFB complement factor B 0.177951
RECQL5 RecQ protein-like 5 0.177799
ARMC9 armadillo repeat containing 9 0.177354
ZNF804B zinc finger protein 804B 0.177354
ASIC2 acid sensing (proton gated) ion channel 2 0.177354
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.177354
ZFPM1 zinc finger protein, FOG family member 1 0.176003
KLF12 Kruppel-like factor 12 0.175121
MTF1 metal-regulatory transcription factor 1 0.174814
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 0.17477
HCG22 HLA complex group 22 0.17427
LOC100506999 uncharacterized LOC100506999 0.171925
TSHZ2 teashirt zinc finger homeobox 2 0.171925
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.171534
ANKRD62P1-PARP4P3 ANKRD62P1-PARP4P3 readthrough, transcribed pseudogene 0.169451
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.169368
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.169205
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.168571
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.168418
CALD1 caldesmon 1 0.168043
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.167824
PFKP phosphofructokinase, platelet 0.16768
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.167258
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.166985
DNAH7 dynein, axonemal, heavy chain 7 0.166587
CLECL1 C-type lectin-like 1 0.165118
RAB20 RAB20, member RAS oncogene family 0.165118
FGD4 FYVE, RhoGEF and PH domain containing 4 0.16506
CALN1 calneuron 1 0.164556
BVES blood vessel epicardial substance 0.164285
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.163607
PRKCE protein kinase C, epsilon 0.163507
SLC35F3 solute carrier family 35, member F3 0.162872
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.16209
LACTB lactamase, beta 0.161654
ZDHHC17 zinc finger, DHHC-type containing 17 0.161654
LRRC4C leucine rich repeat containing 4C 0.161654
THSD4 thrombospondin, type I, domain containing 4 0.160827
PCDH15 protocadherin-related 15 0.160827
RIMS1 regulating synaptic membrane exocytosis 1 0.159544
TACC2 transforming, acidic coiled-coil containing protein 2 0.159192
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.15865
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.158454
VAV1 vav 1 guanine nucleotide exchange factor 0.158421
ANK1 ankyrin 1, erythrocytic 0.158421
MED27 mediator complex subunit 27 0.158356
SNAP47 synaptosomal-associated protein, 47kDa 0.158324
ZDHHC21 zinc finger, DHHC-type containing 21 0.157821
AGER advanced glycosylation end product-specific receptor 0.157698
BTNL2 butyrophilin-like 2 0.157397
LOC440040 glutamate receptor, metabotropic 5 pseudogene 0.157104
HPS1 Hermansky-Pudlak syndrome 1 0.156457
CHN2 chimerin 2 0.15624
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.156133
FOXE1 forkhead box E1 0.155741
C22ORF31 chromosome 22 open reading frame 31 0.155715
CFH complement factor H 0.155386
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 0.155238
FKTN fukutin 0.154994
TASP1 taspase, threonine aspartase, 1 0.154046
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.15342
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.153378
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.153232
RBP4 retinol binding protein 4, plasma 0.153007
VMP1 vacuole membrane protein 1 0.152806
RPH3A rabphilin 3A 0.152376
TTLL6 tubulin tyrosine ligase-like family member 6 0.152224
CEP152 centrosomal protein 152kDa 0.152129
SMIM23 small integral membrane protein 23 0.152129
TRIM15 tripartite motif containing 15 0.152036
PRKCH protein kinase C, eta 0.152017
ARHGAP24 Rho GTPase activating protein 24 0.152017
WISP1 WNT1 inducible signaling pathway protein 1 0.151925
STAC SH3 and cysteine rich domain 0.15187
RTKN2 rhotekin 2 0.151688
ANKRD26 ankyrin repeat domain 26 0.151669
EPAS1 endothelial PAS domain protein 1 0.151473
DFNB31 deafness, autosomal recessive 31 0.15121
MGST3 microsomal glutathione S-transferase 3 0.151072
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.15097
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.15097
IL2RA interleukin 2 receptor, alpha 0.150472
DOCK8 dedicator of cytokinesis 8 0.150456
DLG2 discs, large homolog 2 (Drosophila) 0.15044
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.150311
KIRREL3 kin of IRRE like 3 (Drosophila) 0.150311
TOX2 TOX high mobility group box family member 2 0.150231
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.150152
KLHL29 kelch-like family member 29 0.150152
CHL1 cell adhesion molecule L1-like 0.150152
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.149996
URI1 URI1, prefoldin-like chaperone 0.149841
CSMD3 CUB and Sushi multiple domains 3 0.149795
OPCML opioid binding protein/cell adhesion molecule-like 0.149389
PHACTR1 phosphatase and actin regulator 1 0.14917
DAAM1 dishevelled associated activator of morphogenesis 1 0.148955
RIN2 Ras and Rab interactor 2 0.148884
PRKCA protein kinase C, alpha 0.148856
FAM110B family with sequence similarity 110, member B 0.148688
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.148674
TNNT3 troponin T type 3 (skeletal, fast) 0.148537
CNTN4 contactin 4 0.148401
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.148266
GPC5 glypican 5 0.148266
ERICH1 glutamate-rich 1 0.147744
CAMK1G calcium/calmodulin-dependent protein kinase IG 0.147731
ERCC5 excision repair cross-complementation group 5 0.147244
SNTG1 syntrophin, gamma 1 0.14722
CORO7 coronin 7 0.147208
MACROD2 MACRO domain containing 2 0.146884
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.14679
MAN1C1 mannosidase, alpha, class 1C, member 1 0.146766
KALRN kalirin, RhoGEF kinase 0.141455
UPK1B uroplakin 1B 0.139157
RNF144A ring finger protein 144A 0.137245
AMPH amphiphysin 0.132281
HCG9 HLA complex group 9 (non-protein coding) 0.130035
CIPC CLOCK-interacting pacemaker 0.123168
ACSF3 acyl-CoA synthetase family member 3 0.12246
IRF2BPL interferon regulatory factor 2 binding protein-like 0.116019
LEMD2 LEM domain containing 2 0.115737
CLEC16A C-type lectin domain family 16, member A 0.115737
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.11565