dyclonine-7022 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dyclonine-7022 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR1B activin A receptor, type IB
ADD2 adducin 2 (beta)
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
C19ORF40 chromosome 19 open reading frame 40
C4ORF29 chromosome 4 open reading frame 29
CAMTA1 calmodulin binding transcription activator 1
CCDC186 coiled-coil domain containing 186
CCNT2 cyclin T2
CENPT centromere protein T
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CPT2 carnitine palmitoyltransferase 2
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
DESI2 desumoylating isopeptidase 2
ECE1 endothelin converting enzyme 1
EDA ectodysplasin A
EFNB3 ephrin-B3
EGFR epidermal growth factor receptor
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELOVL5 ELOVL fatty acid elongase 5
ESR1 estrogen receptor 1
FAM214B family with sequence similarity 214, member B
FGL1 fibrinogen-like 1
FZD7 frizzled class receptor 7
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGL immunoglobulin lambda locus
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUNB jun B proto-oncogene
KDSR 3-ketodihydrosphingosine reductase
KIAA0513 KIAA0513
KLF11 Kruppel-like factor 11
LRP5L low density lipoprotein receptor-related protein 5-like
LRP6 low density lipoprotein receptor-related protein 6
LYRM9 LYR motif containing 9
LYST lysosomal trafficking regulator
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEF2A myocyte enhancer factor 2A
MKL1 megakaryoblastic leukemia (translocation) 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRPS12 mitochondrial ribosomal protein S12
MTSS1L metastasis suppressor 1-like
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDE1 nudE neurodevelopment protein 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEU3 sialidase 3 (membrane sialidase)
OSGIN1 oxidative stress induced growth inhibitor 1
PASK PAS domain containing serine/threonine kinase
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PHC1 polyhomeotic homolog 1 (Drosophila)
PLAT plasminogen activator, tissue
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNPLA6 patatin-like phospholipase domain containing 6
POLH polymerase (DNA directed), eta
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRRC2A proline-rich coiled-coil 2A
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRA protein tyrosine phosphatase, receptor type, A
PYCRL pyrroline-5-carboxylate reductase-like
RBBP9 retinoblastoma binding protein 9
RBM34 RNA binding motif protein 34
RPAP1 RNA polymerase II associated protein 1
RRBP1 ribosome binding protein 1
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SASH1 SAM and SH3 domain containing 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SH2B1 SH2B adaptor protein 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS1 suppressor of cytokine signaling 1
SOWAHC sosondowah ankyrin repeat domain family member C
SOX4 SRY (sex determining region Y)-box 4
STK17B serine/threonine kinase 17b
STX7 syntaxin 7
TCP10L t-complex 10-like
TMEM180 transmembrane protein 180
TRD T cell receptor delta locus
TRIM25 tripartite motif containing 25
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VDAC3 voltage-dependent anion channel 3
VPRBP Vpr (HIV-1) binding protein
ZBED1 zinc finger, BED-type containing 1
ZNF224 zinc finger protein 224
ZNF24 zinc finger protein 24
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ADAM15 ADAM metallopeptidase domain 15
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ATAD5 ATPase family, AAA domain containing 5
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BRMS1 breast cancer metastasis suppressor 1
C1ORF106 chromosome 1 open reading frame 106
C21ORF91 chromosome 21 open reading frame 91
C2ORF44 chromosome 2 open reading frame 44
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CEP85 centrosomal protein 85kDa
CLDN9 claudin 9
CLSPN claspin
COCH cochlin
CORO1A coronin, actin binding protein, 1A
CORO2A coronin, actin binding protein, 2A
CTC1 CTS telomere maintenance complex component 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND4C DENN/MADD domain containing 4C
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNA2 DNA replication helicase/nuclease 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EML4 echinoderm microtubule associated protein like 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXOC3 exocyst complex component 3
FSD1 fibronectin type III and SPRY domain containing 1
GAMT guanidinoacetate N-methyltransferase
GLB1L2 galactosidase, beta 1-like 2
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GTF2I general transcription factor IIi
H2AFJ H2A histone family, member J
HIST1H2AJ histone cluster 1, H2aj
HOXC13 homeobox C13
IQSEC2 IQ motif and Sec7 domain 2
IRF9 interferon regulatory factor 9
KCNK15 potassium channel, two pore domain subfamily K, member 15
KLHL26 kelch-like family member 26
KRT13 keratin 13, type I
LAMB2 laminin, beta 2 (laminin S)
LAS1L LAS1-like (S. cerevisiae)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LNPEP leucyl/cystinyl aminopeptidase
LRRC20 leucine rich repeat containing 20
LYPD1 LY6/PLAUR domain containing 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED9 mediator complex subunit 9
METTL2B methyltransferase like 2B
MFAP2 microfibrillar-associated protein 2
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTA2 metastasis associated 1 family, member 2
MXD3 MAX dimerization protein 3
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK3 NIMA-related kinase 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P3H1 prolyl 3-hydroxylase 1
PARD6A par-6 family cell polarity regulator alpha
PCDHA6 protocadherin alpha 6
PELI1 pellino E3 ubiquitin protein ligase 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G10 phospholipase A2, group X
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB17 RAB17, member RAS oncogene family
RABL3 RAB, member of RAS oncogene family-like 3
RAD51B RAD51 paralog B
RFTN1 raftlin, lipid raft linker 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC12A8 solute carrier family 12, member 8
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC41A3 solute carrier family 41, member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPINK4 serine peptidase inhibitor, Kazal type 4
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFBI transforming growth factor, beta-induced, 68kDa
THAP1 THAP domain containing, apoptosis associated protein 1
THBS3 thrombospondin 3
TMEM254 transmembrane protein 254
TRIM52 tripartite motif containing 52
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
USP6 ubiquitin specific peptidase 6
VSIG10 V-set and immunoglobulin domain containing 10
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF282 zinc finger protein 282
ZNF654 zinc finger protein 654
ZNHIT2 zinc finger, HIT-type containing 2