dry eye syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

321 genes co-occuring with the disease dry eye syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
LTF lactotransferrin 1.3952
DNASE1L1 deoxyribonuclease I-like 1 1.3542
BPIFA2 BPI fold containing family A, member 2 1.3494
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 1.34504
PRR4 proline rich 4 (lacrimal) 1.32978
TNF tumor necrosis factor 1.29877
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.26168
LCN1 lipocalin 1 1.25471
LYZ lysozyme 1.25167
HSPG2 heparan sulfate proteoglycan 2 1.24081
LACRT lacritin 1.14348
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.09167
AATF apoptosis antagonizing transcription factor 1.07446
S100A7 S100 calcium binding protein A7 0.99233
IL1B interleukin 1, beta 0.973801
GJB6 gap junction protein, beta 6, 30kDa 0.949936
CD4 CD4 molecule 0.947019
TLR4 toll-like receptor 4 0.915139
MMP9 matrix metallopeptidase 9 0.88475
IL6 interleukin 6 0.853221
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.829459
MUC4 mucin 4, cell surface associated 0.826589
AQP5 aquaporin 5 0.824948
IRAK4 interleukin-1 receptor-associated kinase 4 0.813462
MUC16 mucin 16, cell surface associated 0.806488
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.799513
VSIG4 V-set and immunoglobulin domain containing 4 0.783526
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.778204
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.774114
PKD2L2 polycystic kidney disease 2-like 2 0.768393
SPRR1B small proline-rich protein 1B 0.765127
S100A9 S100 calcium binding protein A9 0.739488
PRSS21 protease, serine, 21 (testisin) 0.730571
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.726929
ARSI arylsulfatase family, member I 0.724502
KLK13 kallikrein-related peptidase 13 0.715215
ADSL adenylosuccinate lyase 0.705547
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.699919
MUC1 mucin 1, cell surface associated 0.699517
CCL2 chemokine (C-C motif) ligand 2 0.698715
S100A8 S100 calcium binding protein A8 0.696707
TGFB1 transforming growth factor, beta 1 0.684692
LYNX1 Ly6/neurotoxin 1 0.680697
IVL involucrin 0.680297
IL1A interleukin 1, alpha 0.661197
STAB1 stabilin 1 0.6608
HMGB1 high mobility group box 1 0.656046
JAK2 Janus kinase 2 0.656046
FLG filaggrin 0.65565
IFNA4 interferon, alpha 4 0.646559
TTR transthyretin 0.645375
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.636315
PADI1 peptidyl arginine deiminase, type I 0.625711
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.619834
CADM1 cell adhesion molecule 1 0.605372
CD40 CD40 molecule, TNF receptor superfamily member 5 0.60303
MUC7 mucin 7, secreted 0.60264
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.6003
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.596012
CD79A CD79a molecule, immunoglobulin-associated alpha 0.593285
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.586665
TRIM21 tripartite motif containing 21 0.581996
DNTT DNA nucleotidylexotransferase 0.574605
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 0.572273
RGPD1 RANBP2-like and GRIP domain containing 1 0.566054
TLR5 toll-like receptor 5 0.55945
AGFG2 ArfGAP with FG repeats 2 0.55518
CXCL10 chemokine (C-X-C motif) ligand 10 0.552463
ICAM1 intercellular adhesion molecule 1 0.550134
HLA-C major histocompatibility complex, class I, C 0.548583
NBAS neuroblastoma amplified sequence 0.548195
TLR3 toll-like receptor 3 0.538893
SPRR1A small proline-rich protein 1A 0.535409
MED4 mediator complex subunit 4 0.524202
ITSN2 intersectin 2 0.509576
FN1 fibronectin 1 0.506123
SPRR2A small proline-rich protein 2A 0.501144
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.501144
CXCR3 chemokine (C-X-C motif) receptor 3 0.499614
MYD88 myeloid differentiation primary response 88 0.498467
FASLG Fas ligand (TNF superfamily, member 6) 0.498467
CCL20 chemokine (C-C motif) ligand 20 0.497703
AOAH acyloxyacyl hydrolase (neutrophil) 0.496939
DGKQ diacylglycerol kinase, theta 110kDa 0.494266
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 0.491978
JUNB jun B proto-oncogene 0.48893
TLR2 toll-like receptor 2 0.487407
MAPK8 mitogen-activated protein kinase 8 0.482464
PADI3 peptidyl arginine deiminase, type III 0.480186
LOR loricrin 0.477909
MSR1 macrophage scavenger receptor 1 0.474498
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.471846
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.467684
PHIP pleckstrin homology domain interacting protein 0.465416
IL1R1 interleukin 1 receptor, type I 0.46466
CD274 CD274 molecule 0.460506
EDA ectodysplasin A 0.459751
MMP21 matrix metallopeptidase 21 0.458619
RAB10 RAB10, member RAS oncogene family 0.457864
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.455601
TFF3 trefoil factor 3 (intestinal) 0.451831
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.448064
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.447687
KLF4 Kruppel-like factor 4 (gut) 0.446935
RANGAP1 Ran GTPase activating protein 1 0.44129
CCL4 chemokine (C-C motif) ligand 4 0.44129
PSIP1 PC4 and SFRS1 interacting protein 1 0.436026
TNPO3 transportin 3 0.436026
CXCL9 chemokine (C-X-C motif) ligand 9 0.429642
E2F7 E2F transcription factor 7 0.428516
DSG3 desmoglein 3 0.42814
RNASE7 ribonuclease, RNase A family, 7 0.42589
SASH1 SAM and SH3 domain containing 1 0.424765
LIPI lipase, member I 0.42289
MARVELD2 MARVEL domain containing 2 0.422515
CCL17 chemokine (C-C motif) ligand 17 0.416896
LDLR low density lipoprotein receptor 0.413901
SCARF1 scavenger receptor class F, member 1 0.403438
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.400826
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.396353
CA6 carbonic anhydrase VI 0.387423
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.381481
RAB27B RAB27B, member RAS oncogene family 0.381481
NAT10 N-acetyltransferase 10 (GCN5-related) 0.378143
STAB2 stabilin 2 0.377031
CST4 cystatin S 0.375179
CCL13 chemokine (C-C motif) ligand 13 0.374809
ILVBL ilvB (bacterial acetolactate synthase)-like 0.372217
SCARB2 scavenger receptor class B, member 2 0.369997
CD40LG CD40 ligand 0.364454
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.357814
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.357446
AREG amphiregulin 0.356709
CD36 CD36 molecule (thrombospondin receptor) 0.354499
ALB albumin 0.352291
CCR6 chemokine (C-C motif) receptor 6 0.345675
PPAN-P2RY11 PPAN-P2RY11 readthrough 0.339073
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 0.339073
MEGF6 multiple EGF-like-domains 6 0.338341
OCLN occludin 0.335778
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.335046
NGF nerve growth factor (beta polypeptide) 0.32373
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.321909
CD200 CD200 molecule 0.321181
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.321181
MMP2 matrix metallopeptidase 2 0.318272
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.317545
SCARB1 scavenger receptor class B, member 1 0.315003
FAM83H family with sequence similarity 83, member H 0.313915
KRT10 keratin 10, type I 0.311739
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.306672
MAPK14 mitogen-activated protein kinase 14 0.301254
KRT1 keratin 1, type II 0.300894
IL10 interleukin 10 0.298371
AIRE autoimmune regulator 0.297291
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.296211
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.291539
JUN jun proto-oncogene 0.290821
XDH xanthine dehydrogenase 0.287952
MUC2 mucin 2, oligomeric mucus/gel-forming 0.28616
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.285444
AQP3 aquaporin 3 (Gill blood group) 0.284728
FFAR4 free fatty acid receptor 4 0.279724
IL17A interleukin 17A 0.278654
DKK4 dickkopf WNT signaling pathway inhibitor 4 0.277584
KDM6B lysine (K)-specific demethylase 6B 0.27687
CCL7 chemokine (C-C motif) ligand 7 0.273664
PRG4 proteoglycan 4 0.272953
TGM3 transglutaminase 3 0.27153
TANK TRAF family member-associated NFKB activator 0.270464
LAX1 lymphocyte transmembrane adaptor 1 0.270108
MMP13 matrix metallopeptidase 13 0.268687
FAM167A family with sequence similarity 167, member A 0.268687
TLR9 toll-like receptor 9 0.267622
RPLP0 ribosomal protein, large, P0 0.264785
IL1RN interleukin 1 receptor antagonist 0.263722
RREB1 ras responsive element binding protein 1 0.261245
RANBP2 RAN binding protein 2 0.260891
SOD2 superoxide dismutase 2, mitochondrial 0.257358
TOLLIP toll interacting protein 0.247852
SCGB1D1 secretoglobin, family 1D, member 1 0.24715
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.24715
ARG1 arginase 1 0.243995
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.241546
NELFCD negative elongation factor complex member C/D 0.240847
SCGB2A1 secretoglobin, family 2A, member 1 0.237706
IL17C interleukin 17C 0.234225
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.231795
HDAC11 histone deacetylase 11 0.228333
TWIST2 twist family bHLH transcription factor 2 0.228333
GLDC glycine dehydrogenase (decarboxylating) 0.227988
E2F6 E2F transcription factor 6 0.225229
ICAM3 intercellular adhesion molecule 3 0.222479
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.221108
ICA1 islet cell autoantigen 1, 69kDa 0.221108
ADSS adenylosuccinate synthase 0.220766
KRT12 keratin 12, type I 0.220424
MAPK9 mitogen-activated protein kinase 9 0.21974
KRT14 keratin 14, type I 0.217352
TLR1 toll-like receptor 1 0.217012
FRMD6 FERM domain containing 6 0.216672
UCN urocortin 0.216672
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.215314
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.215314
CCR7 chemokine (C-C motif) receptor 7 0.214636
CCL3 chemokine (C-C motif) ligand 3 0.213283
TSPO translocator protein (18kDa) 0.209248
ADCY9 adenylate cyclase 9 0.208914
IRF5 interferon regulatory factor 5 0.208245
TLR7 toll-like receptor 7 0.207245
FABP7 fatty acid binding protein 7, brain 0.206248
GAS1 growth arrest-specific 1 0.204263
MMP1 matrix metallopeptidase 1 0.203933
SLURP1 secreted LY6/PLAUR domain containing 1 0.199356
IGF1 insulin-like growth factor 1 (somatomedin C) 0.199033
PKD2L1 polycystic kidney disease 2-like 1 0.197742
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.196459
CD209 CD209 molecule 0.196139
CPVL carboxypeptidase, vitellogenic-like 0.196139
CXCL11 chemokine (C-X-C motif) ligand 11 0.19582
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.195501
CORO1A coronin, actin binding protein, 1A 0.195183
NPR1 natriuretic peptide receptor 1 0.1936
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.193285
ZMYND10 zinc finger, MYND-type containing 10 0.192971
GUCY2C guanylate cyclase 2C 0.192657
SHB Src homology 2 domain containing adaptor protein B 0.190476
PNMA1 paraneoplastic Ma antigen 1 0.187113
CARD8 caspase recruitment domain family, member 8 0.185313
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.18472
IRF3 interferon regulatory factor 3 0.18151
CCL5 chemokine (C-C motif) ligand 5 0.18151
SFTPD surfactant protein D 0.18151
TIMP1 TIMP metallopeptidase inhibitor 1 0.180652
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.179802
PDCD1LG2 programmed cell death 1 ligand 2 0.179239
IRAK3 interleukin-1 receptor-associated kinase 3 0.17896
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.174093
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.172799
TAC1 tachykinin, precursor 1 0.172544
TBX2 T-box 2 0.172291
PRRC2A proline-rich coiled-coil 2A 0.169812
MMP8 matrix metallopeptidase 8 0.16933
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.168148
RNASEH2A ribonuclease H2, subunit A 0.165874
BAX BCL2-associated X protein 0.165655
TF transferrin 0.165435
PTPRJ protein tyrosine phosphatase, receptor type, J 0.164786
RAB3D RAB3D, member RAS oncogene family 0.163523
SSB Sjogren syndrome antigen B (autoantigen La) 0.162306
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.162109
CRYZ crystallin, zeta (quinone reductase) 0.161912
CCNB1 cyclin B1 0.161139
SIGLEC10 sialic acid binding Ig-like lectin 10 0.159838
ACE2 angiotensin I converting enzyme 2 0.145147
RHO rhodopsin 0.145118
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.144692
RBP1 retinol binding protein 1, cellular 0.144657
CENPB centromere protein B, 80kDa 0.144351
CHRM3 cholinergic receptor, muscarinic 3 0.144234
SIX3 SIX homeobox 3 0.14419
SOCS2 suppressor of cytokine signaling 2 0.144126
PRDX6 peroxiredoxin 6 0.1441
TXNL4B thioredoxin-like 4B 0.144057
NMT1 N-myristoyltransferase 1 0.143999
BMP6 bone morphogenetic protein 6 0.143783
SP6 Sp6 transcription factor 0.1433
HAND1 heart and neural crest derivatives expressed 1 0.142984
TOP3A topoisomerase (DNA) III alpha 0.142811
HLA-DMA major histocompatibility complex, class II, DM alpha 0.142222
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.141682
FTL ferritin, light polypeptide 0.141579
FTH1 ferritin, heavy polypeptide 1 0.141579
JAK3 Janus kinase 3 0.141225
SH2D1A SH2 domain containing 1A 0.14104
CRP C-reactive protein, pentraxin-related 0.141016
CLU clusterin 0.140952
LRP5 low density lipoprotein receptor-related protein 5 0.139784
KMT2A lysine (K)-specific methyltransferase 2A 0.139784
SOCS3 suppressor of cytokine signaling 3 0.138639
VCAM1 vascular cell adhesion molecule 1 0.138056
AARS alanyl-tRNA synthetase 0.138029
SALL1 spalt-like transcription factor 1 0.137779
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.137765
IFNL1 interferon, lambda 1 0.137722
CD68 CD68 molecule 0.137708
ANG angiogenin, ribonuclease, RNase A family, 5 0.137694
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.137665
CCL22 chemokine (C-C motif) ligand 22 0.137636
BCAN brevican 0.137505
LY75 lymphocyte antigen 75 0.13722
FADD Fas (TNFRSF6)-associated via death domain 0.137112
PLK2 polo-like kinase 2 0.137112
APOLD1 apolipoprotein L domain containing 1 0.136986
TSLP thymic stromal lymphopoietin 0.136891
NPTXR neuronal pentraxin receptor 0.136875
C3AR1 complement component 3a receptor 1 0.136664
IQGAP1 IQ motif containing GTPase activating protein 1 0.13624
TNIP1 TNFAIP3 interacting protein 1 0.136187
CCL27 chemokine (C-C motif) ligand 27 0.13617
PRKD1 protein kinase D1 0.13617
CTSS cathepsin S 0.13601
MIRLET7B microRNA let-7b 0.135865
GLUL glutamate-ammonia ligase 0.135846
CTGF connective tissue growth factor 0.135717
C3 complement component 3 0.135605
CRHR2 corticotropin releasing hormone receptor 2 0.135414
PNP purine nucleoside phosphorylase 0.135356
MT3 metallothionein 3 0.135218
IGFBP7 insulin-like growth factor binding protein 7 0.135179
MRI1 methylthioribose-1-phosphate isomerase 1 0.135159
GPBAR1 G protein-coupled bile acid receptor 1 0.135159
POU5F1B POU class 5 homeobox 1B 0.135078
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.134792
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.134708
KRT15 keratin 15, type I 0.134666
NRTN neurturin 0.134666
SCAI suppressor of cancer cell invasion 0.134644
LGALS9 lectin, galactoside-binding, soluble, 9 0.134644
BOC BOC cell adhesion associated, oncogene regulated 0.134538
HBEGF heparin-binding EGF-like growth factor 0.134495