drug dependence Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A substance dependence that involves the continued use of drugs despite problems related to use of the substance. (Human Disease Ontology, DOID_9974)
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Genes

281 genes co-occuring with the disease drug dependence in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
OPRM1 opioid receptor, mu 1 1.90614
DRD2 dopamine receptor D2 1.75278
CNR1 cannabinoid receptor 1 (brain) 1.5238
DSTN destrin (actin depolymerizing factor) 1.51413
PDYN prodynorphin 1.5014
FOS FBJ murine osteosarcoma viral oncogene homolog 1.44342
NPFF neuropeptide FF-amide peptide precursor 1.43991
DRD3 dopamine receptor D3 1.41534
DRD4 dopamine receptor D4 1.34156
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.31755
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.30139
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.29571
ANKK1 ankyrin repeat and kinase domain containing 1 1.23733
FYB FYN binding protein 1.22605
OPRD1 opioid receptor, delta 1 1.22345
OPRK1 opioid receptor, kappa 1 1.19661
PENK proenkephalin 1.19186
CRH corticotropin releasing hormone 1.17078
CREB1 cAMP responsive element binding protein 1 1.12867
NISCH nischarin 1.12656
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.12235
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 1.10931
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.10931
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 1.10636
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 1.10216
FGD1 FYVE, RhoGEF and PH domain containing 1 1.10175
FAM53B family with sequence similarity 53, member B 1.0837
ADCY2 adenylate cyclase 2 (brain) 1.07866
CCKBR cholecystokinin B receptor 1.06312
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.05513
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.02524
COMT catechol-O-methyltransferase 1.00668
GRM2 glutamate receptor, metabotropic 2 0.994439
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.994439
TTC12 tetratricopeptide repeat domain 12 0.986849
TH tyrosine hydroxylase 0.986428
OPRL1 opiate receptor-like 1 0.963309
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.959123
POMC proopiomelanocortin 0.958705
DRD1 dopamine receptor D1 0.956196
MAOA monoamine oxidase A 0.944106
MANEA mannosidase, endo-alpha 0.935385
CCK cholecystokinin 0.933727
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.926692
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.926279
FAAH fatty acid amide hydrolase 0.912257
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.894179
DAD1 defender against cell death 1 0.888848
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.868777
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.851583
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.848716
AUTS2 autism susceptibility candidate 2 0.840525
BDNF brain-derived neurotrophic factor 0.839296
INTS8 integrator complex subunit 8 0.836837
NRXN3 neurexin 3 0.824128
CRHR1 corticotropin releasing hormone receptor 1 0.821257
CPLX4 complexin 4 0.804026
CREB3 cAMP responsive element binding protein 3 0.794181
MAOB monoamine oxidase B 0.792131
PNOC prepronociceptin 0.781888
CPLX3 complexin 3 0.765127
HCRTR2 hypocretin (orexin) receptor 2 0.754934
GRM5 glutamate receptor, metabotropic 5 0.752085
EPHB1 EPH receptor B1 0.749237
UBE3C ubiquitin protein ligase E3C 0.74883
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.731381
ADORA1 adenosine A1 receptor 0.712796
TPH2 tryptophan hydroxylase 2 0.711183
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.711183
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.698715
CHRM5 cholinergic receptor, muscarinic 5 0.697109
HOMER2 homer scaffolding protein 2 0.693098
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.691094
CALY calcyon neuron-specific vesicular protein 0.687491
GAL galanin/GMAP prepropeptide 0.681894
HOMER1 homer scaffolding protein 1 0.670333
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.658818
SNPH syntaphilin 0.653671
RGMB repulsive guidance molecule family member b 0.649718
ARRB1 arrestin, beta 1 0.639857
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.628065
DRD5 dopamine receptor D5 0.620617
ADCY8 adenylate cyclase 8 (brain) 0.619442
HCRT hypocretin (orexin) neuropeptide precursor 0.617094
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.59952
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.592506
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.583552
CSNK1E casein kinase 1, epsilon 0.574217
ACPT acid phosphatase, testicular 0.569552
NPY2R neuropeptide Y receptor Y2 0.56722
ARF4 ADP-ribosylation factor 4 0.564889
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.562169
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.558674
SYT2 synaptotagmin II 0.555568
CDNF cerebral dopamine neurotrophic factor 0.554015
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.549359
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.547807
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.537731
CLOCK clock circadian regulator 0.53657
ADH6 alcohol dehydrogenase 6 (class V) 0.532314
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.531154
CCKAR cholecystokinin A receptor 0.52729
CPLX1 complexin 1 0.52536
LY96 lymphocyte antigen 96 0.523045
GALR3 galanin receptor 3 0.51842
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.508424
NPY5R neuropeptide Y receptor Y5 0.507273
CREB3L4 cAMP responsive element binding protein 3-like 4 0.507273
DLL1 delta-like 1 (Drosophila) 0.507273
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.503441
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.501527
GDNF glial cell derived neurotrophic factor 0.497703
GLS2 glutaminase 2 (liver, mitochondrial) 0.489311
MC5R melanocortin 5 receptor 0.488549
TECR trans-2,3-enoyl-CoA reductase 0.483604
CPLX2 complexin 2 0.476772
IFI44L interferon-induced protein 44-like 0.473361
EPHB2 EPH receptor B2 0.467306
VIPR2 vasoactive intestinal peptide receptor 2 0.457487
CIRBP cold inducible RNA binding protein 0.455224
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.452208
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.451454
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.447687
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.445805
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.445805
GRM7 glutamate receptor, metabotropic 7 0.439786
HCRTR1 hypocretin (orexin) receptor 1 0.43941
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.435275
SPATA21 spermatogenesis associated 21 0.434524
HSPH1 heat shock 105kDa/110kDa protein 1 0.428891
GRM1 glutamate receptor, metabotropic 1 0.427015
PRL prolactin 0.424765
ADCY4 adenylate cyclase 4 0.421765
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.418768
CNTN3 contactin 3 (plasmacytoma associated) 0.418768
NCOR2 nuclear receptor corepressor 2 0.415773
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.408292
ADGRL4 adhesion G protein-coupled receptor L4 0.407545
ADCY7 adenylate cyclase 7 0.401199
NOS1 nitric oxide synthase 1 (neuronal) 0.394491
NOTO notochord homeobox 0.388538
GALR1 galanin receptor 1 0.387051
TAC1 tachykinin, precursor 1 0.385936
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.383337
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.382966
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.379256
PIR pirin (iron-binding nuclear protein) 0.373328
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.369628
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.368149
TAC3 tachykinin 3 0.36704
NPY1R neuropeptide Y receptor Y1 0.360764
CORT cortistatin 0.360764
ADORA2A adenosine A2a receptor 0.354868
ADCY1 adenylate cyclase 1 (brain) 0.352659
ADCY3 adenylate cyclase 3 0.35082
GRM3 glutamate receptor, metabotropic 3 0.342739
MOGS mannosyl-oligosaccharide glucosidase 0.340173
MAPK7 mitogen-activated protein kinase 7 0.33651
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.335046
ACTG1 actin gamma 1 0.334681
ADCY10 adenylate cyclase 10 (soluble) 0.32774
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.325552
INSC inscuteable homolog (Drosophila) 0.325552
NPY neuropeptide Y 0.317545
STXBP1 syntaxin binding protein 1 0.316819
ADCY9 adenylate cyclase 9 0.307033
SYT1 synaptotagmin I 0.305226
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.305226
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.304142
OPN3 opsin 3 0.303781
RAB3A RAB3A, member RAS oncogene family 0.302337
TACR3 tachykinin receptor 3 0.300533
ADCY6 adenylate cyclase 6 0.296931
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.296211
ADRA1A adrenoceptor alpha 1A 0.295851
ADCY5 adenylate cyclase 5 0.294053
PATE1 prostate and testis expressed 1 0.291898
GGN gametogenetin 0.28831
ZDHHC23 zinc finger, DHHC-type containing 23 0.280082
DCXR dicarbonyl/L-xylulose reductase 0.278654
STX8 syntaxin 8 0.274376
NTF3 neurotrophin 3 0.271886
NPS neuropeptide S 0.268687
NPSR1 neuropeptide S receptor 1 0.267267
SIX4 SIX homeobox 4 0.255241
MFRP membrane frizzled-related protein 0.254888
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.25207
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.251718
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.250311
ABAT 4-aminobutyrate aminotransferase 0.24996
FOXD3 forkhead box D3 0.243995
COCH cochlin 0.241196
NRG1 neuregulin 1 0.238752
AIM2 absent in melanoma 2 0.235268
FHL1 four and a half LIM domains 1 0.224196
ADRA2A adrenoceptor alpha 2A 0.220424
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.219057
MGP matrix Gla protein 0.219057
RGS4 regulator of G-protein signaling 4 0.216672
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.214975
ACTB actin, beta 0.213959
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.210253
PRDM16 PR domain containing 16 0.206248
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.201308
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.200982
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.200331
TDO2 tryptophan 2,3-dioxygenase 0.200006
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.192031
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.18621
CRHR2 corticotropin releasing hormone receptor 2 0.185612
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.183835
PER2 period circadian clock 2 0.18151
CXADR coxsackie virus and adenovirus receptor 0.181222
AGPS alkylglycerone phosphate synthase 0.181222
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.175947
FKBP5 FK506 binding protein 5 0.175146
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.173832
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.172291
DTNBP1 dystrobrevin binding protein 1 0.172291
NSF N-ethylmaleimide-sensitive factor 0.170544
EFNB1 ephrin-B1 0.170054
ASPN asporin 0.167224
ARRB2 arrestin, beta 2 0.167224
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.165435
CKMT1B creatine kinase, mitochondrial 1B 0.163523
GYPA glycophorin A (MNS blood group) 0.158951
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.158951
MEGF6 multiple EGF-like-domains 6 0.1436
APEH acylaminoacyl-peptide hydrolase 0.142716
C6ORF25 chromosome 6 open reading frame 25 0.139694
NOVA2 neuro-oncological ventral antigen 2 0.137742
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.13772
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.136124
NRL neural retina leucine zipper 0.136043
NPR1 natriuretic peptide receptor 1 0.135791
GUCY2C guanylate cyclase 2C 0.135757
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.135129
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.135076
PLCG1 phospholipase C, gamma 1 0.134721
NOS2 nitric oxide synthase 2, inducible 0.133792
HSPB1 heat shock 27kDa protein 1 0.133214
PEBP1 phosphatidylethanolamine binding protein 1 0.133074
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.132559
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.128136
PER3 period circadian clock 3 0.118251
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.118092
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.117853
GDF5 growth differentiation factor 5 0.117388
HAS1 hyaluronan synthase 1 0.116522
NTSR1 neurotensin receptor 1 (high affinity) 0.115974
MARS methionyl-tRNA synthetase 0.115117
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.113415
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.113191
ADRA1D adrenoceptor alpha 1D 0.112508
BCHE butyrylcholinesterase 0.111472
CTSA cathepsin A 0.109227
BEST1 bestrophin 1 0.108751
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.107595
PSENEN presenilin enhancer gamma secretase subunit 0.107595
NEUROD1 neuronal differentiation 1 0.106949
EXT1 exostosin glycosyltransferase 1 0.106715
F2R coagulation factor II (thrombin) receptor 0.106208
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.106169
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.105975
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.104735
STX1A syntaxin 1A (brain) 0.104119
CHM choroideremia (Rab escort protein 1) 0.103955
NLE1 notchless homolog 1 (Drosophila) 0.10308
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.101759
MGAM maltase-glucoamylase 0.100536
HSPA4 heat shock 70kDa protein 4 0.100051
HSPA8 heat shock 70kDa protein 8 0.099871
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.099781
ENO2 enolase 2 (gamma, neuronal) 0.09942
JUN jun proto-oncogene 0.098834
CNTF ciliary neurotrophic factor 0.098512
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.097262
TPH1 tryptophan hydroxylase 1 0.096697
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.09632
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.09589
VCP valosin containing protein 0.095314