drofenine-3455 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the drofenine-3455 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARHGAP35 Rho GTPase activating protein 35
ASIC1 acid sensing (proton gated) ion channel 1
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CALD1 caldesmon 1
CCDC186 coiled-coil domain containing 186
CCNK cyclin K
CD58 CD58 molecule
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
COL11A2 collagen, type XI, alpha 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF15 DDB1 and CUL4 associated factor 15
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIO2 deiodinase, iodothyronine, type II
DOK4 docking protein 4
EFNA3 ephrin-A3
EGR1 early growth response 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPOR erythropoietin receptor
EPX eosinophil peroxidase
FADS3 fatty acid desaturase 3
FBXL7 F-box and leucine-rich repeat protein 7
FGF18 fibroblast growth factor 18
FGF6 fibroblast growth factor 6
FPR3 formyl peptide receptor 3
FSTL3 follistatin-like 3 (secreted glycoprotein)
GTPBP3 GTP binding protein 3 (mitochondrial)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1D histone cluster 1, H1d
HRK harakiri, BCL2 interacting protein
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL5RA interleukin 5 receptor, alpha
INHBE inhibin, beta E
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCTD7 potassium channel tetramerization domain containing 7
KIF5A kinesin family member 5A
KLHL22 kelch-like family member 22
LARP6 La ribonucleoprotein domain family, member 6
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LHX6 LIM homeobox 6
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LTBP2 latent transforming growth factor beta binding protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MARC2 mitochondrial amidoxime reducing component 2
MCOLN1 mucolipin 1
MED1 mediator complex subunit 1
MEFV Mediterranean fever
MMP13 matrix metallopeptidase 13
NEURL1 neuralized E3 ubiquitin protein ligase 1
NF1 neurofibromin 1
NUMA1 nuclear mitotic apparatus protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OLFML2A olfactomedin-like 2A
PICK1 protein interacting with PRKCA 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP prolactin-induced protein
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PSG9 pregnancy specific beta-1-glycoprotein 9
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RASAL2 RAS protein activator like 2
RNF31 ring finger protein 31
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SDC3 syndecan 3
SGSM3 small G protein signaling modulator 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STOML1 stomatin (EPB72)-like 1
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
TCP11L1 t-complex 11, testis-specific-like 1
TH tyrosine hydroxylase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF2 TNF receptor-associated factor 2
TRIM3 tripartite motif containing 3
TRIM36 tripartite motif containing 36
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
VLDLR very low density lipoprotein receptor
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
ZHX3 zinc fingers and homeoboxes 3
ZNF10 zinc finger protein 10
ZNF202 zinc finger protein 202
ZNF862 zinc finger protein 862
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
AMDHD2 amidohydrolase domain containing 2
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BTBD3 BTB (POZ) domain containing 3
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF80 chromosome 11 open reading frame 80
C2ORF54 chromosome 2 open reading frame 54
CDC37L1 cell division cycle 37-like 1
CDK3 cyclin-dependent kinase 3
CLDND1 claudin domain containing 1
CLK1 CDC-like kinase 1
CORT cortistatin
CRELD1 cysteine-rich with EGF-like domains 1
CRY2 cryptochrome circadian clock 2
CRYBG3 beta-gamma crystallin domain containing 3
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DMC1 DNA meiotic recombinase 1
ECSIT ECSIT signalling integrator
EYA2 EYA transcriptional coactivator and phosphatase 2
FAAH fatty acid amide hydrolase
FANCC Fanconi anemia, complementation group C
FANCE Fanconi anemia, complementation group E
FBRS fibrosin
FBXO31 F-box protein 31
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCHO1 FCH domain only 1
GNL1 guanine nucleotide binding protein-like 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDAC4 histone deacetylase 4
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BE histone cluster 1, H2be
HIST1H3B histone cluster 1, H3b
HMG20A high mobility group 20A
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IRAK4 interleukin-1 receptor-associated kinase 4
KCTD20 potassium channel tetramerization domain containing 20
KCTD3 potassium channel tetramerization domain containing 3
KLHL2 kelch-like family member 2
KLHL26 kelch-like family member 26
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIG1 ligase I, DNA, ATP-dependent
LRP6 low density lipoprotein receptor-related protein 6
LRRC61 leucine rich repeat containing 61
LRRC8E leucine rich repeat containing 8 family, member E
NEK11 NIMA-related kinase 11
NOL6 nucleolar protein 6 (RNA-associated)
NPIPB3 nuclear pore complex interacting protein family, member B3
NUBPL nucleotide binding protein-like
NUP62CL nucleoporin 62kDa C-terminal like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PARD6A par-6 family cell polarity regulator alpha
PC pyruvate carboxylase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G12A phospholipase A2, group XIIA
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP6R3 protein phosphatase 6, regulatory subunit 3
QTRT1 queuine tRNA-ribosyltransferase 1
REEP4 receptor accessory protein 4
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIRT6 sirtuin 6
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SOWAHC sosondowah ankyrin repeat domain family member C
SP1 Sp1 transcription factor
SPATA2L spermatogenesis associated 2-like
SRD5A3 steroid 5 alpha-reductase 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SYCP2 synaptonemal complex protein 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN1 tectonic family member 1
TET3 tet methylcytosine dioxygenase 3
THRAP3 thyroid hormone receptor associated protein 3
TMEM2 transmembrane protein 2
TMEM260 transmembrane protein 260
TMOD3 tropomodulin 3 (ubiquitous)
TOM1 target of myb1 (chicken)
TRIM25 tripartite motif containing 25
TRIM66 tripartite motif containing 66
TTC33 tetratricopeptide repeat domain 33
TUBGCP5 tubulin, gamma complex associated protein 5
URGCP upregulator of cell proliferation
WDR47 WD repeat domain 47
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YEATS4 YEATS domain containing 4
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED8 zinc finger, BED-type containing 8
ZC3H3 zinc finger CCCH-type containing 3
ZNF205 zinc finger protein 205
ZNF211 zinc finger protein 211
ZNF227 zinc finger protein 227
ZNF675 zinc finger protein 675
ZNHIT6 zinc finger, HIT-type containing 6