doxorubicin-4610 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the doxorubicin-4610 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALDOB aldolase B, fructose-bisphosphate
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOA1 apolipoprotein A-I
AREG amphiregulin
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARL4D ADP-ribosylation factor-like 4D
B9D1 B9 protein domain 1
BEST2 bestrophin 2
BTNL2 butyrophilin-like 2
CCL21 chemokine (C-C motif) ligand 21
CD244 CD244 molecule, natural killer cell receptor 2B4
CD4 CD4 molecule
COL3A1 collagen, type III, alpha 1
CORO2B coronin, actin binding protein, 2B
CPA2 carboxypeptidase A2 (pancreatic)
CRP C-reactive protein, pentraxin-related
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DACH1 dachshund family transcription factor 1
DGKE diacylglycerol kinase, epsilon 64kDa
DLX2 distal-less homeobox 2
DPY19L1P1 DPY19L1 pseudogene 1
DRD2 dopamine receptor D2
EDN3 endothelin 3
EPB42 erythrocyte membrane protein band 4.2
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP3 fatty acid binding protein 3, muscle and heart
FGF16 fibroblast growth factor 16
GAB1 GRB2-associated binding protein 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GAST gastrin
GFI1 growth factor independent 1 transcription repressor
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPX7 glutathione peroxidase 7
GRIA3 glutamate receptor, ionotropic, AMPA 3
GSTTP1 glutathione S-transferase theta pseudogene 1
HCRTR2 hypocretin (orexin) receptor 2
HHAT hedgehog acyltransferase
HIST1H2BB histone cluster 1, H2bb
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNMT histamine N-methyltransferase
HOXB3 homeobox B3
IFNA17 interferon, alpha 17
INE1 inactivation escape 1 (non-protein coding)
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
LHX1 LIM homeobox 1
MAGEB2 melanoma antigen family B2
MAU2 MAU2 sister chromatid cohesion factor
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MORN1 MORN repeat containing 1
MYH13 myosin, heavy chain 13, skeletal muscle
NEFM neurofilament, medium polypeptide
NF1 neurofibromin 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
ONECUT1 one cut homeobox 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PCDHA6 protocadherin alpha 6
PCDHGB6 protocadherin gamma subfamily B, 6
PDE11A phosphodiesterase 11A
PDE4DIP phosphodiesterase 4D interacting protein
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POU3F2 POU class 3 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PRKCA protein kinase C, alpha
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RABGAP1L RAB GTPase activating protein 1-like
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBBP9 retinoblastoma binding protein 9
RBM12B RNA binding motif protein 12B
RBMY2FP RNA binding motif protein, Y-linked, family 2, member F pseudogene
RBP3 retinol binding protein 3, interstitial
RGS6 regulator of G-protein signaling 6
RIN3 Ras and Rab interactor 3
RPH3AL rabphilin 3A-like (without C2 domains)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC16A4 solute carrier family 16, member 4
SLC45A2 solute carrier family 45, member 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPAG11A sperm associated antigen 11A
SPI1 Spi-1 proto-oncogene
SRD5A3 steroid 5 alpha-reductase 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SYMPK symplekin
SYNGR4 synaptogyrin 4
SYT5 synaptotagmin V
TAS2R1 taste receptor, type 2, member 1
TAT tyrosine aminotransferase
TGFB2 transforming growth factor, beta 2
VGF VGF nerve growth factor inducible
ZMYND10 zinc finger, MYND-type containing 10
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
ACVR2A activin A receptor, type IIA
ADNP activity-dependent neuroprotector homeobox
ADRB2 adrenoceptor beta 2, surface
AMOTL2 angiomotin like 2
ANKRD49 ankyrin repeat domain 49
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID5B AT rich interactive domain 5B (MRF1-like)
BCAR3 breast cancer anti-estrogen resistance 3
BCL10 B-cell CLL/lymphoma 10
BRIX1 BRX1, biogenesis of ribosomes
C14ORF169 chromosome 14 open reading frame 169
CASP8AP2 caspase 8 associated protein 2
CDCA4 cell division cycle associated 4
CHD1 chromodomain helicase DNA binding protein 1
CHSY1 chondroitin sulfate synthase 1
CLDN4 claudin 4
CLK4 CDC-like kinase 4
CLP1 cleavage and polyadenylation factor I subunit 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYR61 cysteine-rich, angiogenic inducer, 61
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPF2 D4, zinc and double PHD fingers family 2
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
E2F6 E2F transcription factor 6
EXO1 exonuclease 1
FADD Fas (TNFRSF6)-associated via death domain
FOSL1 FOS-like antigen 1
FZD8 frizzled class receptor 8
GBX2 gastrulation brain homeobox 2
GGNBP2 gametogenetin binding protein 2
HAS2 hyaluronan synthase 2
HAUS3 HAUS augmin-like complex, subunit 3
HIST1H4C histone cluster 1, H4c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD1C jumonji domain containing 1C
KANSL2 KAT8 regulatory NSL complex subunit 2
KIF18A kinesin family member 18A
KLF10 Kruppel-like factor 10
MAD2L1BP MAD2L1 binding protein
MED17 mediator complex subunit 17
MORC3 MORC family CW-type zinc finger 3
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUP153 nucleoporin 153kDa
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PNRC2 proline-rich nuclear receptor coactivator 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
RAB20 RAB20, member RAS oncogene family
RBM7 RNA binding motif protein 7
RGS2 regulator of G-protein signaling 2
RIPK4 receptor-interacting serine-threonine kinase 4
RNF113A ring finger protein 113A
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SNAI2 snail family zinc finger 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSFA2 sperm specific antigen 2
SUOX sulfite oxidase
SYBU syntabulin (syntaxin-interacting)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBCC tubulin folding cofactor C
TBCCD1 TBCC domain containing 1
TBK1 TANK-binding kinase 1
TEFM transcription elongation factor, mitochondrial
TGDS TDP-glucose 4,6-dehydratase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM177 transmembrane protein 177
TRIB1 tribbles pseudokinase 1
TRIM13 tripartite motif containing 13
TRIM26 tripartite motif containing 26
TRIM68 tripartite motif containing 68
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VCPKMT valosin containing protein lysine (K) methyltransferase
ZBED5 zinc finger, BED-type containing 5
ZBTB24 zinc finger and BTB domain containing 24
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF12 zinc finger protein 12
ZNF217 zinc finger protein 217
ZNF274 zinc finger protein 274
ZNF394 zinc finger protein 394
ZNF443 zinc finger protein 443
ZNF586 zinc finger protein 586
ZNF7 zinc finger protein 7
ZNF85 zinc finger protein 85