doxorubicin-3291 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the doxorubicin-3291 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACTN2 actinin, alpha 2
ADAM19 ADAM metallopeptidase domain 19
ADAM22 ADAM metallopeptidase domain 22
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX15 arachidonate 15-lipoxygenase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ATRNL1 attractin-like 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BMP1 bone morphogenetic protein 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CCL13 chemokine (C-C motif) ligand 13
CEL carboxyl ester lipase
CEP41 centrosomal protein 41kDa
CGA glycoprotein hormones, alpha polypeptide
CHD5 chromodomain helicase DNA binding protein 5
CLCN7 chloride channel, voltage-sensitive 7
CLDN11 claudin 11
CNOT3 CCR4-NOT transcription complex, subunit 3
COL1A1 collagen, type I, alpha 1
CTIF CBP80/20-dependent translation initiation factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYHR1 cysteine/histidine-rich 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLX2 distal-less homeobox 2
DMTN dematin actin binding protein
E2F5 E2F transcription factor 5, p130-binding
EGF epidermal growth factor
FABP6 fatty acid binding protein 6, ileal
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGL2 fibrinogen-like 2
FKBP10 FK506 binding protein 10, 65 kDa
FOXN3 forkhead box N3
FSCN1 fascin actin-bundling protein 1
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GLS glutaminase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNRHR gonadotropin-releasing hormone receptor
H3F3B H3 histone, family 3B (H3.3B)
HAB1 B1 for mucin
HBEGF heparin-binding EGF-like growth factor
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
IL5RA interleukin 5 receptor, alpha
KIAA0368 KIAA0368
KRT17 keratin 17, type I
LDB3 LIM domain binding 3
LGALS9 lectin, galactoside-binding, soluble, 9
LOXL2 lysyl oxidase-like 2
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MYH14 myosin, heavy chain 14, non-muscle
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NBL1 neuroblastoma 1, DAN family BMP antagonist
NPM3 nucleophosmin/nucleoplasmin 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFML3 olfactomedin-like 3
PRDM11 PR domain containing 11
PSG3 pregnancy specific beta-1-glycoprotein 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB6B RAB6B, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RHBDD3 rhomboid domain containing 3
RPS2 ribosomal protein S2
RUNX1 runt-related transcription factor 1
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SARM1 sterile alpha and TIR motif containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND2P SCAN domain containing 2 pseudogene
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3D21 SH3 domain containing 21
SLC17A4 solute carrier family 17, member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPINK4 serine peptidase inhibitor, Kazal type 4
SYNDIG1 synapse differentiation inducing 1
TCP11L1 t-complex 11, testis-specific-like 1
TGM2 transglutaminase 2
TM4SF4 transmembrane 4 L six family member 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM242 transmembrane protein 242
TUBA4B tubulin, alpha 4b
TXNRD2 thioredoxin reductase 2
ULBP2 UL16 binding protein 2
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)
ZNF280A zinc finger protein 280A

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANKRD49 ankyrin repeat domain 49
ARL4A ADP-ribosylation factor-like 4A
ASTE1 asteroid homolog 1 (Drosophila)
BAMBI BMP and activin membrane-bound inhibitor
BCAR3 breast cancer anti-estrogen resistance 3
BCL10 B-cell CLL/lymphoma 10
CHD1 chromodomain helicase DNA binding protein 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
E2F6 E2F transcription factor 6
EFNA1 ephrin-A1
EFNA4 ephrin-A4
EGR3 early growth response 3
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
GPATCH1 G patch domain containing 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
HOXC6 homeobox C6
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
JMJD1C jumonji domain containing 1C
KIN Kin17 DNA and RNA binding protein
LIPT1 lipoyltransferase 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MED17 mediator complex subunit 17
MED7 mediator complex subunit 7
METTL18 methyltransferase like 18
MGA MGA, MAX dimerization protein
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MSL2 male-specific lethal 2 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYNN myoneurin
NDC80 NDC80 kinetochore complex component
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
OSR2 odd-skipped related transciption factor 2
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PALB2 partner and localizer of BRCA2
PHF21A PHD finger protein 21A
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PNRC2 proline-rich nuclear receptor coactivator 2
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PPAN peter pan homolog (Drosophila)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR15L proline rich 15-like
PUS3 pseudouridylate synthase 3
RANBP6 RAN binding protein 6
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBM7 RNA binding motif protein 7
RHOB ras homolog family member B
RIOK2 RIO kinase 2
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RNF146 ring finger protein 146
RPP38 ribonuclease P/MRP 38kDa subunit
SEC24B SEC24 family member B
SLC38A2 solute carrier family 38, member 2
SPATA2L spermatogenesis associated 2-like
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TGS1 trimethylguanosine synthase 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TSKU tsukushi, small leucine rich proteoglycan
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR5B WD repeat domain 5B
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB10 zinc finger and BTB domain containing 10
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZIC1 Zic family member 1
ZNF107 zinc finger protein 107
ZNF217 zinc finger protein 217
ZNF267 zinc finger protein 267
ZNF273 zinc finger protein 273
ZNF274 zinc finger protein 274
ZNF443 zinc finger protein 443
ZNF587 zinc finger protein 587
ZNF84 zinc finger protein 84
ZSCAN16 zinc finger and SCAN domain containing 16