doxepin-7415 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the doxepin-7415 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHI1 Abelson helper integration site 1
AKAP17A A kinase (PRKA) anchor protein 17A
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BBS9 Bardet-Biedl syndrome 9
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C14ORF93 chromosome 14 open reading frame 93
C9ORF9 chromosome 9 open reading frame 9
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAPG capping protein (actin filament), gelsolin-like
CCDC134 coiled-coil domain containing 134
CCNG2 cyclin G2
CEP162 centrosomal protein 162kDa
CNOT4 CCR4-NOT transcription complex, subunit 4
CTNND2 catenin (cadherin-associated protein), delta 2
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
FADS3 fatty acid desaturase 3
FGFR1 fibroblast growth factor receptor 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPR137 G protein-coupled receptor 137
HIPK3 homeodomain interacting protein kinase 3
HIST1H2BC histone cluster 1, H2bc
IL4R interleukin 4 receptor
IRF5 interferon regulatory factor 5
IRF6 interferon regulatory factor 6
KDM5A lysine (K)-specific demethylase 5A
KIAA0485 uncharacterized LOC57235
KIF13B kinesin family member 13B
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LIMK1 LIM domain kinase 1
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRRC23 leucine rich repeat containing 23
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBD1 methyl-CpG binding domain protein 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MEF2D myocyte enhancer factor 2D
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MVD mevalonate (diphospho) decarboxylase
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP3 NEDD4 binding protein 3
NAAA N-acylethanolamine acid amidase
NCAPH2 non-SMC condensin II complex, subunit H2
NCR2 natural cytotoxicity triggering receptor 2
NKX3-1 NK3 homeobox 1
NPFFR1 neuropeptide FF receptor 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUMA1 nuclear mitotic apparatus protein 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PACS1 phosphofurin acidic cluster sorting protein 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
POFUT1 protein O-fucosyltransferase 1
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRY PTPN13-like, Y-linked
PXDC1 PX domain containing 1
RAB40B RAB40B, member RAS oncogene family
RECQL5 RecQ protein-like 5
RIN1 Ras and Rab interactor 1
RNF39 ring finger protein 39
RSU1 Ras suppressor protein 1
RTN2 reticulon 2
RUFY3 RUN and FYVE domain containing 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH2B1 SH2B adaptor protein 1
SIK2 salt-inducible kinase 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SNAI2 snail family zinc finger 2
SND1-IT1 SND1 intronic transcript 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SYMPK symplekin
SYNGR1 synaptogyrin 1
TADA2A transcriptional adaptor 2A
TAPBP TAP binding protein (tapasin)
TRAIP TRAF interacting protein
TRIM2 tripartite motif containing 2
TTC33 tetratricopeptide repeat domain 33
USP34 ubiquitin specific peptidase 34
VLDLR very low density lipoprotein receptor
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWTR1 WW domain containing transcription regulator 1
YTHDC2 YTH domain containing 2
ZFAND6 zinc finger, AN1-type domain 6
ZMYM2 zinc finger, MYM-type 2
ZNF136 zinc finger protein 136
ZNF45 zinc finger protein 45

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACO1 aconitase 1, soluble
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APOO apolipoprotein O
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARL15 ADP-ribosylation factor-like 15
AXIN1 axin 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAHD1 bromo adjacent homology domain containing 1
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
CLSPN claspin
COQ9 coenzyme Q9
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDIT3 DNA-damage-inducible transcript 3
ECH1 enoyl CoA hydratase 1, peroxisomal
FBXL15 F-box and leucine-rich repeat protein 15
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FSD1 fibronectin type III and SPRY domain containing 1
FUZ fuzzy planar cell polarity protein
FZD4 frizzled class receptor 4
GAREM GRB2 associated, regulator of MAPK1
GJA1 gap junction protein, alpha 1, 43kDa
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR87 G protein-coupled receptor 87
HMBOX1 homeobox containing 1
HOXC10 homeobox C10
IRX4 iroquois homeobox 4
KLHL21 kelch-like family member 21
KRBOX4 KRAB box domain containing 4
LHFPL2 lipoma HMGIC fusion partner-like 2
LOC100272216 uncharacterized LOC100272216
LOC100287590 uncharacterized LOC100287590
LRRC37A2 leucine rich repeat containing 37, member A2
LYPD1 LY6/PLAUR domain containing 1
LZTFL1 leucine zipper transcription factor-like 1
MAGEH1 melanoma antigen family H1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCOLN1 mucolipin 1
MEIS1 Meis homeobox 1
MICALL2 MICAL-like 2
MUM1 melanoma associated antigen (mutated) 1
MYO1E myosin IE
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
NRSN2 neurensin 2
NVL nuclear VCP-like
PCSK7 proprotein convertase subtilisin/kexin type 7
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
PEX26 peroxisomal biogenesis factor 26
PGPEP1 pyroglutamyl-peptidase I
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PMM1 phosphomannomutase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RCOR3 REST corepressor 3
RNASEH2B ribonuclease H2, subunit B
RNF123 ring finger protein 123
RNF126P1 ring finger protein 126 pseudogene 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SNORA21 small nucleolar RNA, H/ACA box 21
SPATA7 spermatogenesis associated 7
STX17 syntaxin 17
TBC1D17 TBC1 domain family, member 17
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM7SF3 transmembrane 7 superfamily member 3
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
TXNL4B thioredoxin-like 4B
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
WDR60 WD repeat domain 60
YEATS2 YEATS domain containing 2
YIPF1 Yip1 domain family, member 1
ZNF205 zinc finger protein 205
ZNF286A zinc finger protein 286A
ZNF428 zinc finger protein 428
ZNF787 zinc finger protein 787
ZW10 zw10 kinetochore protein