doxazosin-3024 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the doxazosin-3024 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABHD6 abhydrolase domain containing 6
ADAM22 ADAM metallopeptidase domain 22
ADRBK1 adrenergic, beta, receptor kinase 1
AGFG2 ArfGAP with FG repeats 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
C19ORF73 chromosome 19 open reading frame 73
C21ORF2 chromosome 21 open reading frame 2
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC85B coiled-coil domain containing 85B
CCSER2 coiled-coil serine-rich protein 2
CD84 CD84 molecule
CDCP1 CUB domain containing protein 1
CIDEC cell death-inducing DFFA-like effector c
CLDN17 claudin 17
CLDN9 claudin 9
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRAT carnitine O-acetyltransferase
CREM cAMP responsive element modulator
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNASE2 deoxyribonuclease II, lysosomal
DNMBP dynamin binding protein
DOC2B double C2-like domains, beta
DUSP4 dual specificity phosphatase 4
EMP1 epithelial membrane protein 1
EPHA4 EPH receptor A4
FGD1 FYVE, RhoGEF and PH domain containing 1
FLT1 fms-related tyrosine kinase 1
FMO6P flavin containing monooxygenase 6 pseudogene
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS2 growth arrest-specific 2
GK3P glycerol kinase 3 pseudogene
GPRC5C G protein-coupled receptor, class C, group 5, member C
HIST1H4B histone cluster 1, H4b
ICAM1 intercellular adhesion molecule 1
ICAM5 intercellular adhesion molecule 5, telencephalin
IFI6 interferon, alpha-inducible protein 6
IL12RB2 interleukin 12 receptor, beta 2
INA internexin neuronal intermediate filament protein, alpha
INF2 inverted formin, FH2 and WH2 domain containing
IRS4 insulin receptor substrate 4
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
IZUMO4 IZUMO family member 4
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIAA0040 KIAA0040
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
KLF12 Kruppel-like factor 12
KLHL35 kelch-like family member 35
LAMA5 laminin, alpha 5
LAMC3 laminin, gamma 3
LIG3 ligase III, DNA, ATP-dependent
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOC730101 uncharacterized LOC730101
LRRC36 leucine rich repeat containing 36
MISP mitotic spindle positioning
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
OPRL1 opiate receptor-like 1
OSBPL10 oxysterol binding protein-like 10
PBX2 pre-B-cell leukemia homeobox 2
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGBD5 piggyBac transposable element derived 5
PIGR polymeric immunoglobulin receptor
RECQL5 RecQ protein-like 5
RELN reelin
RGS5 regulator of G-protein signaling 5
RHOH ras homolog family member H
RIPPLY3 ripply transcriptional repressor 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAFB scaffold attachment factor B
SARM1 sterile alpha and TIR motif containing 1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SP4 Sp4 transcription factor
SPPL2B signal peptide peptidase like 2B
SPTBN4 spectrin, beta, non-erythrocytic 4
TAS2R16 taste receptor, type 2, member 16
TCP10 t-complex 10
TDRD12 tudor domain containing 12
TIMP2 TIMP metallopeptidase inhibitor 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAF1 TNF receptor-associated factor 1
TRIM29 tripartite motif containing 29
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TXNRD3 thioredoxin reductase 3
UNC119 unc-119 homolog (C. elegans)
USP29 ubiquitin specific peptidase 29
VAV2 vav 2 guanine nucleotide exchange factor
ZNF276 zinc finger protein 276
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACPP acid phosphatase, prostate
ADTRP androgen-dependent TFPI-regulating protein
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARMCX4 armadillo repeat containing, X-linked 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BACE1 beta-site APP-cleaving enzyme 1
BBC3 BCL2 binding component 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRIX1 BRX1, biogenesis of ribosomes
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
C9ORF9 chromosome 9 open reading frame 9
CASS4 Cas scaffolding protein family member 4
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDR2 cerebellar degeneration-related protein 2, 62kDa
CDR2L cerebellar degeneration-related protein 2-like
CLTCL1 clathrin, heavy chain-like 1
CROT carnitine O-octanoyltransferase
CRTAP cartilage associated protein
DCAF17 DDB1 and CUL4 associated factor 17
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB1 defensin, beta 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DSPP dentin sialophosphoprotein
DZANK1 double zinc ribbon and ankyrin repeat domains 1
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FKBP5 FK506 binding protein 5
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
GPR27 G protein-coupled receptor 27
HAMP hepcidin antimicrobial peptide
HIST1H2AI histone cluster 1, H2ai
HIST1H2BN histone cluster 1, H2bn
HIST1H3B histone cluster 1, H3b
ICK intestinal cell (MAK-like) kinase
IL12RB1 interleukin 12 receptor, beta 1
IL2 interleukin 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA1456 KIAA1456
KLHL26 kelch-like family member 26
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY75 lymphocyte antigen 75
MANSC1 MANSC domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTD1 mbt domain containing 1
MRPS18C mitochondrial ribosomal protein S18C
MRPS27 mitochondrial ribosomal protein S27
MTSS1L metastasis suppressor 1-like
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCKAP1L NCK-associated protein 1-like
NDE1 nudE neurodevelopment protein 1
NTSR1 neurotensin receptor 1 (high affinity)
ODF2 outer dense fiber of sperm tails 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLAT plasminogen activator, tissue
PLTP phospholipid transfer protein
PMFBP1 polyamine modulated factor 1 binding protein 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS53 protease, serine, 53
QTRT1 queuine tRNA-ribosyltransferase 1
RAB13 RAB13, member RAS oncogene family
RCAN3 RCAN family member 3
RFTN1 raftlin, lipid raft linker 1
RHOBTB1 Rho-related BTB domain containing 1
SENP7 SUMO1/sentrin specific peptidase 7
SIL1 SIL1 nucleotide exchange factor
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX12 SRY (sex determining region Y)-box 12
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TIAM2 T-cell lymphoma invasion and metastasis 2
TICAM1 toll-like receptor adaptor molecule 1
TMEM212 transmembrane protein 212
TMEM38B transmembrane protein 38B
TRAIP TRAF interacting protein
TRDMT1 tRNA aspartic acid methyltransferase 1
UPK3A uroplakin 3A
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB3 zinc finger and BTB domain containing 3
ZNF286A zinc finger protein 286A
ZNF37BP zinc finger protein 37B, pseudogene
ZNF529 zinc finger protein 529
ZNF668 zinc finger protein 668
ZNF76 zinc finger protein 76