down syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability. (Human Disease Ontology, DOID_14250)
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Genes

548 genes co-occuring with the disease down syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.72481
AFP alpha-fetoprotein 2.53637
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 2.48794
RCAN1 regulator of calcineurin 1 2.20363
DSCAM Down syndrome cell adhesion molecule 2.11582
SIM2 single-minded family bHLH transcription factor 2 1.81555
DSCR3 Down syndrome critical region 3 1.7709
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 1.70542
APP amyloid beta (A4) precursor protein 1.60726
SOD2 superoxide dismutase 2, mitochondrial 1.57824
PFKL phosphofructokinase, liver 1.56978
TTC3 tetratricopeptide repeat domain 3 1.56356
DOPEY2 dopey family member 2 1.54186
SH3BGR SH3 domain binding glutamate-rich protein 1.5194
MAST4 microtubule associated serine/threonine kinase family member 4 1.51896
ITSN1 intersectin 1 (SH3 domain protein) 1.50974
CBS cystathionine-beta-synthase 1.50798
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 1.50316
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1.49438
ZBTB21 zinc finger and BTB domain containing 21 1.44825
SH3BGRL SH3 domain binding glutamate-rich protein like 1.4421
CRELD1 cysteine-rich with EGF-like domains 1 1.43113
SYNJ1 synaptojanin 1 1.41884
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.40176
TMEM50B transmembrane protein 50B 1.38472
RCAN2 regulator of calcineurin 2 1.37687
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 1.36902
DBN1 drebrin 1 1.36379
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.35899
S100B S100 calcium binding protein B 1.35071
DSCR4 Down syndrome critical region 4 1.34766
WRB tryptophan rich basic protein 1.33414
APOE apolipoprotein E 1.33021
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 1.32192
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.31362
WDR4 WD repeat domain 4 1.29964
CBR1 carbonyl reductase 1 1.29483
CHAT choline O-acetyltransferase 1.28217
CRLF2 cytokine receptor-like factor 2 1.27301
BACE2 beta-site APP-cleaving enzyme 2 1.27083
RCAN3 RCAN family member 3 1.27039
PKNOX1 PBX/knotted 1 homeobox 1 1.22649
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 1.22388
FPR1 formyl peptide receptor 1 1.21392
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 1.21262
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 1.17851
HMGN1 high mobility group nucleosome binding domain 1 1.16521
RIPPLY3 ripply transcriptional repressor 3 1.14051
GPX1 glutathione peroxidase 1 1.13501
ADAM12 ADAM metallopeptidase domain 12 1.1194
RUNX1 runt-related transcription factor 1 1.11772
GPX5 glutathione peroxidase 5 1.11183
GPX4 glutathione peroxidase 4 1.10804
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1.09671
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 1.08495
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 1.07278
NGF nerve growth factor (beta polypeptide) 1.06564
GABPA GA binding protein transcription factor, alpha subunit 60kDa 1.05345
COL6A1 collagen, type VI, alpha 1 1.03746
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 1.03198
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 1.02313
ACHE acetylcholinesterase (Yt blood group) 1.01047
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.991909
FAM207A family with sequence similarity 207, member A 0.979268
C6ORF203 chromosome 6 open reading frame 203 0.979268
RBM4B RNA binding motif protein 4B 0.979268
SMIM11 small integral membrane protein 11 0.979268
MRPL39 mitochondrial ribosomal protein L39 0.979268
DONSON downstream neighbor of SON 0.979268
LINC01547 long intergenic non-protein coding RNA 1547 0.979268
DSCR8 Down syndrome critical region 8 0.97086
WDR20 WD repeat domain 20 0.943274
CD79A CD79a molecule, immunoglobulin-associated alpha 0.939119
MAPT microtubule-associated protein tau 0.935385
PCP4 Purkinje cell protein 4 0.93207
PLD6 phospholipase D family, member 6 0.927932
C21ORF33 chromosome 21 open reading frame 33 0.915551
PFKM phosphofructokinase, muscle 0.91061
MX1 MX dynamin-like GTPase 1 0.908553
AGO2 argonaute RISC catalytic component 2 0.904032
MORC3 MORC family CW-type zinc finger 3 0.901567
INHA inhibin, alpha 0.890078
FMR1 fragile X mental retardation 1 0.882701
OSCAR osteoclast associated, immunoglobulin-like receptor 0.880653
BACE1 beta-site APP-cleaving enzyme 1 0.879424
CCL4 chemokine (C-C motif) ligand 4 0.877786
USP25 ubiquitin specific peptidase 25 0.874919
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 0.865912
DNM1 dynamin 1 0.859771
YBEY ybeY metallopeptidase (putative) 0.851583
NUP93 nucleoporin 93kDa 0.851583
MIRLET7C microRNA let-7c 0.813052
SOD1 superoxide dismutase 1, soluble 0.812642
CABIN1 calcineurin binding protein 1 0.805257
EPGN epithelial mitogen 0.805257
PRDM15 PR domain containing 15 0.801154
PAPPA2 pappalysin 2 0.797872
CAT catalase 0.792131
MECP2 methyl CpG binding protein 2 0.791721
COL6A2 collagen, type VI, alpha 2 0.790492
GRIK1 glutamate receptor, ionotropic, kainate 1 0.781069
RBM11 RNA binding motif protein 11 0.780251
PSG9 pregnancy specific beta-1-glycoprotein 9 0.779841
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.774523
RHD Rh blood group, D antigen 0.774523
C21ORF2 chromosome 21 open reading frame 2 0.772887
HCST hematopoietic cell signal transducer 0.771252
REPS1 RALBP1 associated Eps domain containing 1 0.770844
PSEN1 presenilin 1 0.770435
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 0.76921
CBR3 carbonyl reductase 3 0.768393
SNX27 sorting nexin family member 27 0.762678
BRWD1 bromodomain and WD repeat domain containing 1 0.762271
UMODL1 uromodulin-like 1 0.760231
TIAM1 T-cell lymphoma invasion and metastasis 1 0.759824
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.754934
PTER phosphotriesterase related 0.749644
CORO7 coronin 7 0.749237
TMOD2 tropomodulin 2 (neuronal) 0.745172
CLK3 CDC-like kinase 3 0.74436
CD33 CD33 molecule 0.740299
DCXR dicarbonyl/L-xylulose reductase 0.730571
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.729762
SETD4 SET domain containing 4 0.729762
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.729762
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.724502
EVA1C eva-1 homolog C (C. elegans) 0.72127
C21ORF58 chromosome 21 open reading frame 58 0.711989
BDNF brain-derived neurotrophic factor 0.705547
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.691896
RABIF RAB interacting factor 0.689092
BHMT betaine--homocysteine S-methyltransferase 0.686691
EPS15 epidermal growth factor receptor pathway substrate 15 0.681894
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.681495
ZRANB1 zinc finger, RAN-binding domain containing 1 0.680297
JAK2 Janus kinase 2 0.676706
PGF placental growth factor 0.673917
ALPP alkaline phosphatase, placental 0.671527
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.66596
STRIP1 striatin interacting protein 1 0.66596
STRIP2 striatin interacting protein 2 0.66596
MRPS18A mitochondrial ribosomal protein S18A 0.66596
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.665166
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.664372
DSCAML1 Down syndrome cell adhesion molecule like 1 0.662387
SUMO3 small ubiquitin-like modifier 3 0.659215
BCHE butyrylcholinesterase 0.654858
DRAXIN dorsal inhibitory axon guidance protein 0.649718
ICT1 immature colon carcinoma transcript 1 0.647743
SIM1 single-minded family bHLH transcription factor 1 0.642615
ALPPL2 alkaline phosphatase, placental-like 2 0.642221
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.641433
ALPL alkaline phosphatase, liver/bone/kidney 0.641433
SUMO2 small ubiquitin-like modifier 2 0.641039
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.638282
AMPH amphiphysin 0.637102
SH3GL2 SH3-domain GRB2-like 2 0.633956
MCM8 minichromosome maintenance complex component 8 0.623751
SH3GLB2 SH3-domain GRB2-like endophilin B2 0.623359
LAX1 lymphocyte transmembrane adaptor 1 0.621792
PRMT2 protein arginine methyltransferase 2 0.620226
OLIG2 oligodendrocyte lineage transcription factor 2 0.620226
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.612401
UBB ubiquitin B 0.610057
AIRE autoimmune regulator 0.603811
CST3 cystatin C 0.60108
PFKP phosphofructokinase, platelet 0.596402
SERP2 stress-associated endoplasmic reticulum protein family member 2 0.594843
CD7 CD7 molecule 0.593285
NRIP1 nuclear receptor interacting protein 1 0.590558
OLIG1 oligodendrocyte transcription factor 1 0.588222
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.581996
PUS10 pseudouridylate synthase 10 0.580439
ACTG1 actin gamma 1 0.578494
PCBP3 poly(rC) binding protein 3 0.578106
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.574605
TPO thyroid peroxidase 0.570329
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 0.569552
ACTB actin, beta 0.567997
MAP2 microtubule-associated protein 2 0.566054
NRD1 nardilysin (N-arginine dibasic convertase) 0.564112
SNAP25 synaptosomal-associated protein, 25kDa 0.556344
NANS N-acetylneuraminic acid synthase 0.554015
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.554015
GATA2 GATA binding protein 2 0.543542
GSR glutathione reductase 0.535409
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 0.533088
JAK3 Janus kinase 3 0.531154
OR1E1 olfactory receptor, family 1, subfamily E, member 1 0.530768
CREB1 cAMP responsive element binding protein 1 0.529222
SYNGR2 synaptogyrin 2 0.528063
MCM3AP minichromosome maintenance complex component 3 associated protein 0.526904
NCAM1 neural cell adhesion molecule 1 0.521888
CTSB cathepsin B 0.521117
POFUT2 protein O-fucosyltransferase 2 0.520346
TAGLN3 transgelin 3 0.518805
FABP7 fatty acid binding protein 7, brain 0.518805
RGAG1 retrotransposon gag domain containing 1 0.514571
HSPA13 heat shock protein 70kDa family, member 13 0.505739
PAXBP1 PAX3 and PAX7 binding protein 1 0.503824
CD4 CD4 molecule 0.500761
ETV6 ets variant 6 0.496939
SRPRB signal recognition particle receptor, B subunit 0.496557
CTH cystathionine gamma-lyase 0.494648
NPDC1 neural proliferation, differentiation and control, 1 0.491597
ARHGAP25 Rho GTPase activating protein 25 0.491597
ENO2 enolase 2 (gamma, neuronal) 0.490454
RGS7BP regulator of G-protein signaling 7 binding protein 0.487788
CLEC3B C-type lectin domain family 3, member B 0.486646
MAP3K7CL MAP3K7 C-terminal like 0.485125
AMELX amelogenin, X-linked 0.483985
RHCE Rh blood group, CcEe antigens 0.483985
EDNRB endothelin receptor type B 0.483985
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 0.479807
SPANXA2 SPANX family, member A2 0.479807
PHB2 prohibitin 2 0.477909
ENSA endosulfine alpha 0.47374
CDK5 cyclin-dependent kinase 5 0.473361
RAD54L2 RAD54-like 2 (S. cerevisiae) 0.471089
NEFH neurofilament, heavy polypeptide 0.469197
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.468063
CPA1 carboxypeptidase A1 (pancreatic) 0.46466
RRP1B ribosomal RNA processing 1B 0.462772
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.462394
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.460883
CP ceruloplasmin (ferroxidase) 0.460506
CLDN14 claudin 14 0.460129
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.459373
PSG6 pregnancy specific beta-1-glycoprotein 6 0.457109
BTG3 BTG family, member 3 0.456732
CD34 CD34 molecule 0.456732
FN1 fibronectin 1 0.453716
NEFM neurofilament, medium polypeptide 0.453339
APCS amyloid P component, serum 0.451831
PCNT pericentrin 0.451454
GRM5 glutamate receptor, metabotropic 5 0.448817
MUC13 mucin 13, cell surface associated 0.447687
OR5AC2 olfactory receptor, family 5, subfamily AC, member 2 0.443171
REST RE1-silencing transcription factor 0.440914
LARS leucyl-tRNA synthetase 0.439786
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.439034
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.439034
EGR3 early growth response 3 0.435651
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.435275
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.430768
SMC1B structural maintenance of chromosomes 1B 0.429266
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.428516
PDE9A phosphodiesterase 9A 0.427015
SYP synaptophysin 0.42289
TG thyroglobulin 0.42214
KIF17 kinesin family member 17 0.41727
CHODL chondrolectin 0.416896
PRNP prion protein 0.416521
TPTE transmembrane phosphatase with tensin homology 0.41465
LGALS13 lectin, galactoside-binding, soluble, 13 0.409787
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.40904
GTF3A general transcription factor IIIA 0.408666
MRPL13 mitochondrial ribosomal protein L13 0.408666
ERP29 endoplasmic reticulum protein 29 0.405678
GSN gelsolin 0.405678
DLG2 discs, large homolog 2 (Drosophila) 0.403811
VIP vasoactive intestinal peptide 0.399707
PAX5 paired box 5 0.399707
ZFPM1 zinc finger protein, FOG family member 1 0.399334
AMELY amelogenin, Y-linked 0.398962
CD19 CD19 molecule 0.398216
NFYA nuclear transcription factor Y, alpha 0.396353
NIT2 nitrilase family, member 2 0.391885
CLDN8 claudin 8 0.390397
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 0.390397
RSU1 Ras suppressor protein 1 0.389653
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 0.388538
SNORA29 small nucleolar RNA, H/ACA box 29 0.386308
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 0.385193
MZF1 myeloid zinc finger 1 0.384079
TFB1M transcription factor B1, mitochondrial 0.384079
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.381852
LEP leptin 0.381481
IL10RB interleukin 10 receptor, beta 0.379256
LIG3 ligase III, DNA, ATP-dependent 0.378514
FLT3 fms-related tyrosine kinase 3 0.378514
DYNLT3 dynein, light chain, Tctex-type 3 0.37592
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.374809
GFAP glial fibrillary acidic protein 0.373328
JAK1 Janus kinase 1 0.372587
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 0.371107
VSX1 visual system homeobox 1 0.369997
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.368888
MAP4 microtubule-associated protein 4 0.368518
STMN2 stathmin 2 0.368518
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.36741
CALB1 calbindin 1, 28kDa 0.36704
CCBL1 cysteine conjugate-beta lyase, cytoplasmic 0.365562
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.364824
TMPRSS15 transmembrane protease, serine 15 0.362978
HP haptoglobin 0.361133
SP4 Sp4 transcription factor 0.360395
IMMT inner membrane protein, mitochondrial 0.357446
CTRL chymotrypsin-like 0.357077
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 0.356709
C8A complement component 8, alpha polypeptide 0.355972
HPR haptoglobin-related protein 0.355235
CSTB cystatin B (stefin B) 0.354131
KDM2A lysine (K)-specific demethylase 2A 0.352291
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 0.351923
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 0.350084
MANF mesencephalic astrocyte-derived neurotrophic factor 0.350084
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 0.348246
UXT ubiquitously-expressed, prefoldin-like chaperone 0.347144
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 0.347144
DSE dermatan sulfate epimerase 0.346777
LHCGR luteinizing hormone/choriogonadotropin receptor 0.346777
SEPT5 septin 5 0.346409
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.346409
USP28 ubiquitin specific peptidase 28 0.344941
NOTCH1 notch 1 0.340173
PLXNC1 plexin C1 0.340173
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 0.337242
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.336144
B3GAT1 beta-1,3-glucuronyltransferase 1 0.334315
RBM4 RNA binding motif protein 4 0.334315
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.333949
PARVA parvin, alpha 0.333583
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.331025
FGFR3 fibroblast growth factor receptor 3 0.3292
FTCD formimidoyltransferase cyclodeaminase 0.32774
CSH2 chorionic somatomammotropin hormone 2 0.32701
TUBB1 tubulin, beta 1 class VI 0.326646
TF transferrin 0.325916
GATA5 GATA binding protein 5 0.324823
SNCB synuclein, beta 0.324458
CMC4 C-x(9)-C motif containing 4 0.323365
ANAPC1 anaphase promoting complex subunit 1 0.321545
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.321181
TMEM131 transmembrane protein 131 0.319363
MME membrane metallo-endopeptidase 0.318272
AMBP alpha-1-microglobulin/bikunin precursor 0.315003
DCC DCC netrin 1 receptor 0.315003
MPO myeloperoxidase 0.31464
CD48 CD48 molecule 0.313189
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.312827
PRDX6 peroxiredoxin 6 0.309566
CLIC6 chloride intracellular channel 6 0.308118
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.307033
TFDP3 transcription factor Dp family, member 3 0.305587
UBA3 ubiquitin-like modifier activating enzyme 3 0.301976
GCFC2 GC-rich sequence DNA-binding factor 2 0.301615
TP53 tumor protein p53 0.301615
FANCL Fanconi anemia, complementation group L 0.299812
IL2 interleukin 2 0.299452
TTR transthyretin 0.294413
ETV3 ets variant 3 0.294053
PDE10A phosphodiesterase 10A 0.293694
PAX2 paired box 2 0.293334
CD1B CD1b molecule 0.292975
DCK deoxycytidine kinase 0.290821
GSK3B glycogen synthase kinase 3 beta 0.290462
C8B complement component 8, beta polypeptide 0.290462
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.290462
JAM2 junctional adhesion molecule 2 0.290103
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 0.289386
STRBP spermatid perinuclear RNA binding protein 0.28831
G6PD glucose-6-phosphate dehydrogenase 0.287593
PER1 period circadian clock 1 0.286877
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.286519
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.28616
RPL15 ribosomal protein L15 0.28616
PICALM phosphatidylinositol binding clathrin assembly protein 0.285444
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.283297
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.28294
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.282225
CSNK1D casein kinase 1, delta 0.281153
LDOC1 leucine zipper, down-regulated in cancer 1 0.281153
ERCC3 excision repair cross-complementation group 3 0.280796
RNF7 ring finger protein 7 0.280082
FMNL3 formin-like 3 0.278654
NBAS neuroblastoma amplified sequence 0.278297
SRSF4 serine/arginine-rich splicing factor 4 0.27794
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.275445
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.27153
NF1 neurofibromin 1 0.270464
BCLAF1 BCL2-associated transcription factor 1 0.269753
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.268332
USF1 upstream transcription factor 1 0.267977
CD36 CD36 molecule (thrombospondin receptor) 0.267267
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.266558
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.266558
NCR3 natural cytotoxicity triggering receptor 3 0.26514
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.26514
SYN1 synapsin I 0.264785
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.263722
SNX1 sorting nexin 1 0.261952
GLIS2 GLIS family zinc finger 2 0.261245
PGK1 phosphoglycerate kinase 1 0.260891
PSEN2 presenilin 2 0.260538
HRK harakiri, BCL2 interacting protein 0.25983
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 0.258417
SPAG5 sperm associated antigen 5 0.257711
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.256652
NCK2 NCK adaptor protein 2 0.256652
NEXN nexilin (F actin binding protein) 0.256299
L1CAM L1 cell adhesion molecule 0.255946
CLTA clathrin, light chain A 0.253479
KIF21A kinesin family member 21A 0.253127
TMPRSS2 transmembrane protease, serine 2 0.251366
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.251366
NACA nascent polypeptide-associated complex alpha subunit 0.251015
TPH1 tryptophan hydroxylase 1 0.250311
SRY sex determining region Y 0.248554
NADK NAD kinase 0.247852
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.247501
ERLIN2 ER lipid raft associated 2 0.244696
UBASH3A ubiquitin associated and SH3 domain containing A 0.244696
APRT adenine phosphoribosyltransferase 0.243645
ABHD16A abhydrolase domain containing 16A 0.243295
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) 0.239799
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.239101
IFNA5 interferon, alpha 5 0.239101
VDAC3 voltage-dependent anion channel 3 0.238403
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.238403
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 0.237706
PHF1 PHD finger protein 1 0.237357
DCAF7 DDB1 and CUL4 associated factor 7 0.237009
CLIC2 chloride intracellular channel 2 0.236312
GPC4 glypican 4 0.235616
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.235616
SLC26A5 solute carrier family 26 (anion exchanger), member 5 0.234225
PHIP pleckstrin homology domain interacting protein 0.23353
CASZ1 castor zinc finger 1 0.230063
DAPK3 death-associated protein kinase 3 0.229716
ADAR adenosine deaminase, RNA-specific 0.229024
NR2E1 nuclear receptor subfamily 2, group E, member 1 0.229024
CGB7 chorionic gonadotropin, beta polypeptide 7 0.228679
MT4 metallothionein 4 0.228333
CGB5 chorionic gonadotropin, beta polypeptide 5 0.227297
GRID2 glutamate receptor, ionotropic, delta 2 0.226952
TRAPPC10 trafficking protein particle complex 10 0.225917
VAC14 Vac14 homolog (S. cerevisiae) 0.225229
LHX8 LIM homeobox 8 0.222479
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.222136
COL18A1 collagen, type XVIII, alpha 1 0.222136
LIMD1 LIM domains containing 1 0.221793
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.221108
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.219398
PRDX3 peroxiredoxin 3 0.219398
DNAI2 dynein, axonemal, intermediate chain 2 0.219398
EPHA1 EPH receptor A1 0.218715
RET ret proto-oncogene 0.218034
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.217693
CDK1 cyclin-dependent kinase 1 0.217352
ELANE elastase, neutrophil expressed 0.216672
SCN2B sodium channel, voltage gated, type II beta subunit 0.215992
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.214636
RBMS1 RNA binding motif, single stranded interacting protein 1 0.214297
NKX1-1 NK1 homeobox 1 0.213283
NPAS4 neuronal PAS domain protein 4 0.213283
HRH3 histamine receptor H3 0.213283
HRAS Harvey rat sarcoma viral oncogene homolog 0.212608
MAGEA9 melanoma antigen family A9 0.211597
INS insulin 0.211597
MAGEA9B melanoma antigen family A9B 0.211597
MT3 metallothionein 3 0.211261
HIPK3 homeodomain interacting protein kinase 3 0.210925
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.209918
SCARB2 scavenger receptor class B, member 2 0.207912
PBX1 pre-B-cell leukemia homeobox 1 0.206913
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.20658
CGB chorionic gonadotropin, beta polypeptide 0.205585
CGB8 chorionic gonadotropin, beta polypeptide 8 0.204923
TSPY10 testis specific protein, Y-linked 10 0.203604
TSPY3 testis specific protein, Y-linked 3 0.203604
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 0.203604
TAL1 T-cell acute lymphocytic leukemia 1 0.203275
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.202946
DST dystonin 0.202946
SPO11 SPO11 meiotic protein covalently bound to DSB 0.200982
HIAT1 hippocampus abundant transcript 1 0.199681
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.199681
EIF3F eukaryotic translation initiation factor 3, subunit F 0.199033
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.198709
SHH sonic hedgehog 0.197099
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.19582
REG1A regenerating islet-derived 1 alpha 0.195183
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.194548
CALB2 calbindin 2 0.194232
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.192971
COL6A3 collagen, type VI, alpha 3 0.191719
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 0.190786
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.190168
IGF1 insulin-like growth factor 1 (somatomedin C) 0.190168
ST7 suppression of tumorigenicity 7 0.187719
LAMA1 laminin, alpha 1 0.187415
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.187113
PARD3 par-3 family cell polarity regulator 0.185612
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.184424
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.183541
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.183248
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 0.183248
OR5K1 olfactory receptor, family 5, subfamily K, member 1 0.182375
HBG2 hemoglobin, gamma G 0.181798
RELN reelin 0.181222
GAP43 growth associated protein 43 0.180367
NLGN2 neuroligin 2 0.180367
MATR3 matrin 3 0.179802
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.179802
RIPK4 receptor-interacting serine-threonine kinase 4 0.179239
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.179239
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.17896
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.178403
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.178126
JUN jun proto-oncogene 0.177029
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.176757
CDKL5 cyclin-dependent kinase-like 5 0.175679
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.175679
FST follistatin 0.175411
SEPT11 septin 11 0.175146
HBE1 hemoglobin, epsilon 1 0.173832
GOSR2 golgi SNAP receptor complex member 2 0.173832
TRH thyrotropin-releasing hormone 0.173571
ST18 suppression of tumorigenicity 18, zinc finger 0.172799
TRAC T cell receptor alpha constant 0.172291
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.171785
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.171785
THPO thrombopoietin 0.171535
IGLL1 immunoglobulin lambda-like polypeptide 1 0.171286
XYLT2 xylosyltransferase II 0.171286
FSIP1 fibrous sheath interacting protein 1 0.171036
NFYB nuclear transcription factor Y, beta 0.171036
CXADR coxsackie virus and adenovirus receptor 0.16933
CDA cytidine deaminase 0.168617
GRB2 growth factor receptor-bound protein 2 0.168148
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 0.167452
ALB albumin 0.166995
POMC proopiomelanocortin 0.165001
HEXIM1 hexamethylene bis-acetamide inducible 1 0.165001
SCARB1 scavenger receptor class B, member 1 0.164786
IL1B interleukin 1, beta 0.163729
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.163523
RND1 Rho family GTPase 1 0.162707
CST1 cystatin SN 0.162505
FAM3B family with sequence similarity 3, member B 0.161716
ATM ATM serine/threonine kinase 0.160761
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.160203
DTNA dystrobrevin, alpha 0.160021
FCMR Fc fragment of IgM receptor 0.15948
UNC5A unc-5 homolog A (C. elegans) 0.15948
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.157602
RTN1 reticulon 1 0.157602