double Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

316 genes co-occuring with the biological term double in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADGRL3 adhesion G protein-coupled receptor L3
ADRB1 adrenoceptor beta 1
AGO2 argonaute RISC catalytic component 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15B arachidonate 15-lipoxygenase, type B
ALOX5 arachidonate 5-lipoxygenase
ANKK1 ankyrin repeat and kinase domain containing 1
ANXA5 annexin A5
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARID4A AT rich interactive domain 4A (RBP1-like)
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BAX BCL2-associated X protein
BCCIP BRCA2 and CDKN1A interacting protein
BCL2L1 BCL2-like 1
BCO2 beta-carotene oxygenase 2
BCR breakpoint cluster region
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BLM Bloom syndrome, RecQ helicase-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD2 bromodomain containing 2
BRD3 bromodomain containing 3
BSND barttin CLCNK-type chloride channel accessory beta subunit
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
C10ORF2 chromosome 10 open reading frame 2
C5 complement component 5
C7ORF49 chromosome 7 open reading frame 49
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2
CCDC26 CCDC26 long non-coding RNA
CCNA1 cyclin A1
CCR2 chemokine (C-C motif) receptor 2
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD46 CD46 molecule, complement regulatory protein
CD5 CD5 molecule
CDA cytidine deaminase
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CECR2 cat eye syndrome chromosome region, candidate 2
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHN1 chimerin 1
CLCNKA chloride channel, voltage-sensitive Ka
CLCNKB chloride channel, voltage-sensitive Kb
CLN5 ceroid-lipofuscinosis, neuronal 5
CNR1 cannabinoid receptor 1 (brain)
COX2
CRYZ crystallin, zeta (quinone reductase)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCLRE1C DNA cross-link repair 1C
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DMD dystrophin
DNA2 DNA replication helicase/nuclease 2
DRD2 dopamine receptor D2
DSC2 desmocollin 2
DSCAM Down syndrome cell adhesion molecule
DSG2 desmoglein 2
DSP desmoplakin
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENG endoglin
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
ERCC6 excision repair cross-complementation group 6
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FANCD2 Fanconi anemia, complementation group D2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FEN1 flap structure-specific endonuclease 1
FGF7 fibroblast growth factor 7
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FLNA filamin A, alpha
FYN FYN proto-oncogene, Src family tyrosine kinase
GBA glucosidase, beta, acid
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GH2 growth hormone 2
GHR growth hormone receptor
GJB2 gap junction protein, beta 2, 26kDa
GJB6 gap junction protein, beta 6, 30kDa
GMNN geminin, DNA replication inhibitor
GPR68 G protein-coupled receptor 68
GRHL2 grainyhead-like 2 (Drosophila)
GRK6 G protein-coupled receptor kinase 6
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H2AFX H2A histone family, member X
HAS1 hyaluronan synthase 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST2H3C histone cluster 2, H3c
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGB2 high mobility group box 2
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
IAPP islet amyloid polypeptide
IFIH1 interferon induced with helicase C domain 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL10 interleukin 10
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL6 interleukin 6
INS insulin
ITM2B integral membrane protein 2B
JAK2 Janus kinase 2
KAT5 K(lysine) acetyltransferase 5
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KDM4A lysine (K)-specific demethylase 4A
KIAA0101 KIAA0101
KRT19 keratin 19, type I
LAMA2 laminin, alpha 2
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LMNA lamin A/C
LPA lipoprotein, Lp(a)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP1S microtubule-associated protein 1S
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MBP myelin basic protein
MC3R melanocortin 3 receptor
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECP2 methyl CpG binding protein 2
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MICA MHC class I polypeptide-related sequence A
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MPL MPL proto-oncogene, thrombopoietin receptor
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSX1 msh homeobox 1
MT-TH tRNA
MTA1 metastasis associated 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH9 myosin, heavy chain 9, non-muscle
NBN nibrin
NEK8 NIMA-related kinase 8
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF1 neurofibromin 1
NHEJ1 nonhomologous end-joining factor 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPPB natriuretic peptide B
NR2E3 nuclear receptor subfamily 2, group E, member 3
NTHL1 nth endonuclease III-like 1 (E. coli)
NTM neurotrimin
NTN1 netrin 1
NUP210 nucleoporin 210kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGN osteoglycin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPCML opioid binding protein/cell adhesion molecule-like
OPRM1 opioid receptor, mu 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PARP1 poly (ADP-ribose) polymerase 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX3 paired box 3
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PDCD6IP programmed cell death 6 interacting protein
PDZK1 PDZ domain containing 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PITX2 paired-like homeodomain 2
PKP2 plakophilin 2
PLAT plasminogen activator, tissue
PLTP phospholipid transfer protein
PNKP polynucleotide kinase 3'-phosphatase
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POMT1 protein-O-mannosyltransferase 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT7 protein arginine methyltransferase 7
PRRT2 proline-rich transmembrane protein 2
PSEN1 presenilin 1
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
RET ret proto-oncogene
RMI1 RecQ mediated genome instability 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF169 ring finger protein 169
RPA1 replication protein A1, 70kDa
RPE65 retinal pigment epithelium-specific protein 65kDa
RSF1 remodeling and spacing factor 1
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SBDS Shwachman-Bodian-Diamond syndrome
SCN5A sodium channel, voltage gated, type V alpha subunit
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETX senataxin
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC45A3 solute carrier family 45, member 3
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMPX small muscle protein, X-linked
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
TDP1 tyrosyl-DNA phosphodiesterase 1
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TF transferrin
TIMP1 TIMP metallopeptidase inhibitor 1
TLK1 tousled-like kinase 1
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNNT2 troponin T type 2 (cardiac)
TOP1 topoisomerase (DNA) I
TOR1B torsin family 1, member B (torsin B)
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TPSAB1 tryptase alpha/beta 1
TRB T cell receptor beta locus
TRIM28 tripartite motif containing 28
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UIMC1 ubiquitin interaction motif containing 1
UNC5C unc-5 homolog C (C. elegans)
USP15 ubiquitin specific peptidase 15
UTF1 undifferentiated embryonic cell transcription factor 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VWF von Willebrand factor
WRN Werner syndrome, RecQ helicase-like
XPC xeroderma pigmentosum, complementation group C
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YBX1 Y box binding protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFPM2 zinc finger protein, FOG family member 2