double-strand break repair Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. (Gene Ontology, GO_0006302)
External Link http://amigo.geneontology.org/amigo/term/GO:0006302
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Genes

125 genes participating in the double-strand break repair biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLF aprataxin and PNKP like factor
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BABAM1 BRISC and BRCA1 A complex member 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C9ORF142 chromosome 9 open reading frame 142
CCDC155 coiled-coil domain containing 155
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA5 cell division cycle associated 5
CHEK2 checkpoint kinase 2
CIB1 calcium and integrin binding 1 (calmyrin)
DCLRE1C DNA cross-link repair 1C
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DTX3L deltex 3 like, E3 ubiquitin ligase
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
EYA1 EYA transcriptional coactivator and phosphatase 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM175A family with sequence similarity 175, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FEN1 flap structure-specific endonuclease 1
GEN1 GEN1 Holliday junction 5' flap endonuclease
H2AFX H2A histone family, member X
HELQ helicase, POLQ-like
HUS1 HUS1 checkpoint homolog (S. pombe)
HUS1B HUS1 checkpoint homolog b (S. pombe)
INO80 INO80 complex subunit
KAT5 K(lysine) acetyltransferase 5
KDM2A lysine (K)-specific demethylase 2A
KIAA0430 KIAA0430
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDC1 mediator of DNA-damage checkpoint 1
MEIOB meiosis specific with OB domains
MLH1 mutL homolog 1
MMS22L MMS22-like, DNA repair protein
MORF4L1 mortality factor 4 like 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NABP1 nucleic acid binding protein 1
NABP2 nucleic acid binding protein 2
NBN nibrin
NHEJ1 nonhomologous end-joining factor 1
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
PALB2 partner and localizer of BRCA2
PAPD7 PAP associated domain containing 7
PARP1 poly (ADP-ribose) polymerase 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP9 poly (ADP-ribose) polymerase family, member 9
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLN polymerase (DNA directed) nu
POLQ polymerase (DNA directed), theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF19 pre-mRNA processing factor 19
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RAD21 RAD21 homolog (S. pombe)
RAD21L1 RAD21-like 1 (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
REC8 REC8 meiotic recombination protein
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
SETMAR SET domain and mariner transposase fusion gene
SETX senataxin
SFPQ splicing factor proline/glutamine-rich
SFR1 SWI5-dependent recombination repair 1
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SLX4 SLX4 structure-specific endonuclease subunit
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMC5 structural maintenance of chromosomes 5
SMC6 structural maintenance of chromosomes 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIDR scaffolding protein involved in DNA repair
SWI5 SWI5 recombination repair homolog (yeast)
SWSAP1 SWIM-type zinc finger 7 associated protein 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TONSL tonsoku-like, DNA repair protein
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TRIP13 thyroid hormone receptor interactor 13
UBE2N ubiquitin-conjugating enzyme E2N
UIMC1 ubiquitin interaction motif containing 1
VCP valosin containing protein
WDR48 WD repeat domain 48
WRN Werner syndrome, RecQ helicase-like
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XRCC6BP1 XRCC6 binding protein 1
YY1 YY1 transcription factor
ZFYVE26 zinc finger, FYVE domain containing 26
ZSWIM7 zinc finger, SWIM-type containing 7