double-strand break repair via homologous recombination Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. (Gene Ontology, GO_0000724)
External Link http://amigo.geneontology.org/amigo/term/GO:0000724
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Genes

70 genes participating in the double-strand break repair via homologous recombination biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CCDC155 coiled-coil domain containing 155
CDC45 cell division cycle 45
CDC7 cell division cycle 7
ERCC4 excision repair cross-complementation group 4
FAN1 FANCD2/FANCI-associated nuclease 1
GEN1 GEN1 Holliday junction 5' flap endonuclease
H2AFX H2A histone family, member X
HELQ helicase, POLQ-like
HUS1 HUS1 checkpoint homolog (S. pombe)
HUS1B HUS1 checkpoint homolog b (S. pombe)
INO80 INO80 complex subunit
LIG1 ligase I, DNA, ATP-dependent
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDC1 mediator of DNA-damage checkpoint 1
MEIOB meiosis specific with OB domains
MMS22L MMS22-like, DNA repair protein
MORF4L1 mortality factor 4 like 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NABP1 nucleic acid binding protein 1
NABP2 nucleic acid binding protein 2
NBN nibrin
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
PALB2 partner and localizer of BRCA2
POLN polymerase (DNA directed) nu
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RAD21L1 RAD21-like 1 (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
REC8 REC8 meiotic recombination protein
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
SFPQ splicing factor proline/glutamine-rich
SFR1 SWI5-dependent recombination repair 1
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SLX4 SLX4 structure-specific endonuclease subunit
SMC5 structural maintenance of chromosomes 5
SMC6 structural maintenance of chromosomes 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIDR scaffolding protein involved in DNA repair
SWI5 SWI5 recombination repair homolog (yeast)
SWSAP1 SWIM-type zinc finger 7 associated protein 1
TONSL tonsoku-like, DNA repair protein
TP53BP1 tumor protein p53 binding protein 1
UBE2N ubiquitin-conjugating enzyme E2N
WDR48 WD repeat domain 48
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YY1 YY1 transcription factor
ZFYVE26 zinc finger, FYVE domain containing 26
ZSWIM7 zinc finger, SWIM-type containing 7