dosulepin-2864 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the dosulepin-2864 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY10 adenylate cyclase 10 (soluble)
ADGRA2 adhesion G protein-coupled receptor A2
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARC activity-regulated cytoskeleton-associated protein
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEGAIN brain-enriched guanylate kinase-associated
C17ORF59 chromosome 17 open reading frame 59
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CD177 CD177 molecule
CD34 CD34 molecule
CD82 CD82 molecule
CDO1 cysteine dioxygenase type 1
CEP164 centrosomal protein 164kDa
CLEC4E C-type lectin domain family 4, member E
CNTLN centlein, centrosomal protein
COL1A1 collagen, type I, alpha 1
CTSF cathepsin F
CYHR1 cysteine/histidine-rich 1
DAPK1 death-associated protein kinase 1
DMBT1 deleted in malignant brain tumors 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPF1 D4, zinc and double PHD fingers family 1
EGFL7 EGF-like-domain, multiple 7
ERP44 endoplasmic reticulum protein 44
ETV7 ets variant 7
FAM174B family with sequence similarity 174, member B
FBXO2 F-box protein 2
FGFR4 fibroblast growth factor receptor 4
GAL3ST4 galactose-3-O-sulfotransferase 4
GCGR glucagon receptor
GGT1 gamma-glutamyltransferase 1
GRM4 glutamate receptor, metabotropic 4
GRPR gastrin-releasing peptide receptor
HFE hemochromatosis
HIST1H3E histone cluster 1, H3e
HIST1H3I histone cluster 1, H3i
HRASLS2 HRAS-like suppressor 2
ICA1 islet cell autoantigen 1, 69kDa
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0391 KIAA0391
KLF9 Kruppel-like factor 9
KRT38 keratin 38, type I
KRTAP2-4 keratin associated protein 2-4
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LMNA lamin A/C
MAGEA3 melanoma antigen family A3
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MFGE8 milk fat globule-EGF factor 8 protein
MMP3 matrix metallopeptidase 3
MRPL41 mitochondrial ribosomal protein L41
MX2 MX dynamin-like GTPase 2
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYOD1 myogenic differentiation 1
NEUROD1 neuronal differentiation 1
NF1 neurofibromin 1
NOX1 NADPH oxidase 1
NPPA natriuretic peptide A
NRTN neurturin
NTF3 neurotrophin 3
OPCML opioid binding protein/cell adhesion molecule-like
OSBPL2 oxysterol binding protein-like 2
PAIP2B poly(A) binding protein interacting protein 2B
PGLYRP4 peptidoglycan recognition protein 4
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLLP plasmolipin
POU5F1B POU class 5 homeobox 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP4R4 protein phosphatase 4, regulatory subunit 4
PQLC2 PQ loop repeat containing 2
RAP2B RAP2B, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RIMS3 regulating synaptic membrane exocytosis 3
RNF126P1 ring finger protein 126 pseudogene 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDC2 syndecan 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMC1A structural maintenance of chromosomes 1A
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
STAT2 signal transducer and activator of transcription 2, 113kDa
STXBP5L syntaxin binding protein 5-like
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TBC1D2 TBC1 domain family, member 2
USP22 ubiquitin specific peptidase 22
ZNF350 zinc finger protein 350
ZNF778 zinc finger protein 778
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTL8 actin-like 8
ADRBK2 adrenergic, beta, receptor kinase 2
AGMAT agmatine ureohydrolase (agmatinase)
AMT aminomethyltransferase
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
C19ORF73 chromosome 19 open reading frame 73
C1ORF159 chromosome 1 open reading frame 159
C1ORF56 chromosome 1 open reading frame 56
C5ORF45 chromosome 5 open reading frame 45
CCDC69 coiled-coil domain containing 69
CHKB choline kinase beta
CIC capicua transcriptional repressor
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF4 DDB1 and CUL4 associated factor 4
DNALI1 dynein, axonemal, light intermediate chain 1
FAM110B family with sequence similarity 110, member B
FAM189A2 family with sequence similarity 189, member A2
FBXL2 F-box and leucine-rich repeat protein 2
FGF23 fibroblast growth factor 23
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AI histone cluster 1, H2ai
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL17RA interleukin 17 receptor A
INPP1 inositol polyphosphate-1-phosphatase
IQCG IQ motif containing G
ITPKC inositol-trisphosphate 3-kinase C
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA0754 KIAA0754
KIF13B kinesin family member 13B
KLHL36 kelch-like family member 36
KREMEN2 kringle containing transmembrane protein 2
LIG4 ligase IV, DNA, ATP-dependent
LRP5 low density lipoprotein receptor-related protein 5
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP1S microtubule-associated protein 1S
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MON1B MON1 secretory trafficking family member B
MT1H metallothionein 1H
MTERF4 mitochondrial transcription termination factor 4
MYOZ3 myozenin 3
NKX3-2 NK3 homeobox 2
NOL10 nucleolar protein 10
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
POLH polymerase (DNA directed), eta
PPT2 palmitoyl-protein thioesterase 2
PRR4 proline rich 4 (lacrimal)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSKH1 protein serine kinase H1
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3D RAB3D, member RAS oncogene family
RETN resistin
RIN2 Ras and Rab interactor 2
RPAP1 RNA polymerase II associated protein 1
SAYSD1 SAYSVFN motif domain containing 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHPK sedoheptulokinase
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMAD7 SMAD family member 7
SP1 Sp1 transcription factor
SUN2 Sad1 and UNC84 domain containing 2
TFF2 trefoil factor 2
TH tyrosine hydroxylase
TMOD1 tropomodulin 1
TRIM36 tripartite motif containing 36
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSGA10 testis specific, 10
TSPAN5 tetraspanin 5
TTC30A tetratricopeptide repeat domain 30A
VEGFC vascular endothelial growth factor C
WDR33 WD repeat domain 33
XAB2 XPA binding protein 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZNF268 zinc finger protein 268
ZNF324 zinc finger protein 324
ZNF329 zinc finger protein 329
ZNF37BP zinc finger protein 37B, pseudogene
ZNF480 zinc finger protein 480
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747