dorzolamide-6259 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the dorzolamide-6259 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACTA1 actin, alpha 1, skeletal muscle
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AQP3 aquaporin 3 (Gill blood group)
B9D2 B9 protein domain 2
BSDC1 BSD domain containing 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC14B cell division cycle 14B
CDC25C cell division cycle 25C
CDK14 cyclin-dependent kinase 14
CDK9 cyclin-dependent kinase 9
CDRT1 CMT1A duplicated region transcript 1
CEP162 centrosomal protein 162kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHRM3 cholinergic receptor, muscarinic 3
CREM cAMP responsive element modulator
CUL4B cullin 4B
DMC1 DNA meiotic recombinase 1
DNASE1L3 deoxyribonuclease I-like 3
DRD2 dopamine receptor D2
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EFNB3 ephrin-B3
EGR1 early growth response 1
EHBP1L1 EH domain binding protein 1-like 1
EML2 echinoderm microtubule associated protein like 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
F13A1 coagulation factor XIII, A1 polypeptide
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCMR Fc fragment of IgM receptor
FGF6 fibroblast growth factor 6
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAB1 GRB2-associated binding protein 1
GATA4 GATA binding protein 4
GFOD2 glucose-fructose oxidoreductase domain containing 2
GM2A GM2 ganglioside activator
GYG2 glycogenin 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNMT histamine N-methyltransferase
IDI2-AS1 IDI2 antisense RNA 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
INPP5J inositol polyphosphate-5-phosphatase J
IQCG IQ motif containing G
JAK3 Janus kinase 3
JMJD4 jumonji domain containing 4
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KLHL25 kelch-like family member 25
KRT31 keratin 31, type I
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP12 low density lipoprotein receptor-related protein 12
LUZP1 leucine zipper protein 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MANBA mannosidase, beta A, lysosomal
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEGF9 multiple EGF-like-domains 9
MFGE8 milk fat globule-EGF factor 8 protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYOF myoferlin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK9 NIMA-related kinase 9
NF1 neurofibromin 1
NPAS3 neuronal PAS domain protein 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
PARD6B par-6 family cell polarity regulator beta
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCNX pecanex homolog (Drosophila)
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDCD2 programmed cell death 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDZD2 PDZ domain containing 2
PGAP1 post-GPI attachment to proteins 1
PLSCR3 phospholipid scramblase 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPT2 palmitoyl-protein thioesterase 2
PSD3 pleckstrin and Sec7 domain containing 3
QKI QKI, KH domain containing, RNA binding
SIRT5 sirtuin 5
SMC1A structural maintenance of chromosomes 1A
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX9 SRY (sex determining region Y)-box 9
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SUGP2 SURP and G patch domain containing 2
TESK1 testis-specific kinase 1
TNR tenascin R
TRAPPC10 trafficking protein particle complex 10
USP34 ubiquitin specific peptidase 34
VCX2 variable charge, X-linked 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WWOX WW domain containing oxidoreductase
ZNF224 zinc finger protein 224
ZNF701 zinc finger protein 701
ZSCAN12 zinc finger and SCAN domain containing 12

decreased expression

Symbol Name
AES amino-terminal enhancer of split
AGBL5 ATP/GTP binding protein-like 5
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
AXIN1 axin 1
BAHD1 bromo adjacent homology domain containing 1
C11ORF80 chromosome 11 open reading frame 80
C16ORF45 chromosome 16 open reading frame 45
C19ORF40 chromosome 19 open reading frame 40
C6ORF47 chromosome 6 open reading frame 47
CCDC85C coiled-coil domain containing 85C
CISH cytokine inducible SH2-containing protein
COL4A5 collagen, type IV, alpha 5
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DOCK1 dedicator of cytokinesis 1
ELOVL4 ELOVL fatty acid elongase 4
EPHA2 EPH receptor A2
ERCC4 excision repair cross-complementation group 4
FAM188A family with sequence similarity 188, member A
FBXL2 F-box and leucine-rich repeat protein 2
GAB2 GRB2-associated binding protein 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45G growth arrest and DNA-damage-inducible, gamma
GLCE glucuronic acid epimerase
GLS2 glutaminase 2 (liver, mitochondrial)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTPBP2 GTP binding protein 2
H2AFY2 H2A histone family, member Y2
HIST1H1E histone cluster 1, H1e
IFT81 intraflagellar transport 81
IGSF1 immunoglobulin superfamily, member 1
IL15RA interleukin 15 receptor, alpha
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLHL26 kelch-like family member 26
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMA3 laminin, alpha 3
LIN37 lin-37 DREAM MuvB core complex component
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MPST mercaptopyruvate sulfurtransferase
MRPL2 mitochondrial ribosomal protein L2
MRPL52 mitochondrial ribosomal protein L52
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NEK11 NIMA-related kinase 11
NFS1 NFS1 cysteine desulfurase
NPIPB15 nuclear pore complex interacting protein family, member B15
NRGN neurogranin (protein kinase C substrate, RC3)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PANX1 pannexin 1
PC pyruvate carboxylase
PGP phosphoglycolate phosphatase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POLI polymerase (DNA directed) iota
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMT2 protein-O-mannosyltransferase 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFTN1 raftlin, lipid raft linker 1
RNF219 ring finger protein 219
RNF31 ring finger protein 31
RPL23AP7 ribosomal protein L23a pseudogene 7
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPIDR scaffolding protein involved in DNA repair
SSFA2 sperm specific antigen 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYCP2 synaptonemal complex protein 2
TAGLN transgelin
TDRD1 tudor domain containing 1
TMEM104 transmembrane protein 104
TMEM160 transmembrane protein 160
TMEM39B transmembrane protein 39B
TPST2 tyrosylprotein sulfotransferase 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM66 tripartite motif containing 66
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
ULBP2 UL16 binding protein 2
WLS wntless Wnt ligand secretion mediator
ZC3H12A zinc finger CCCH-type containing 12A
ZNF14 zinc finger protein 14
ZNF211 zinc finger protein 211
ZNF254 zinc finger protein 254
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787
ZYX zyxin