| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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196 genes differentially expressed following the dorzolamide-6259 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| A1CF | APOBEC1 complementation factor |
| ACTA1 | actin, alpha 1, skeletal muscle |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 |
| AQP3 | aquaporin 3 (Gill blood group) |
| B9D2 | B9 protein domain 2 |
| BSDC1 | BSD domain containing 1 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase |
| CDC14B | cell division cycle 14B |
| CDC25C | cell division cycle 25C |
| CDK14 | cyclin-dependent kinase 14 |
| CDK9 | cyclin-dependent kinase 9 |
| CDRT1 | CMT1A duplicated region transcript 1 |
| CEP162 | centrosomal protein 162kDa |
| CFLAR | CASP8 and FADD-like apoptosis regulator |
| CHRM3 | cholinergic receptor, muscarinic 3 |
| CREM | cAMP responsive element modulator |
| CUL4B | cullin 4B |
| DMC1 | DNA meiotic recombinase 1 |
| DNASE1L3 | deoxyribonuclease I-like 3 |
| DRD2 | dopamine receptor D2 |
| DTX2P1-UPK3BP1-PMS2P11 | DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene |
| EFNB3 | ephrin-B3 |
| EGR1 | early growth response 1 |
| EHBP1L1 | EH domain binding protein 1-like 1 |
| EML2 | echinoderm microtubule associated protein like 2 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) |
| F13A1 | coagulation factor XIII, A1 polypeptide |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
| FCMR | Fc fragment of IgM receptor |
| FGF6 | fibroblast growth factor 6 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 |
| GAB1 | GRB2-associated binding protein 1 |
| GATA4 | GATA binding protein 4 |
| GFOD2 | glucose-fructose oxidoreductase domain containing 2 |
| GM2A | GM2 ganglioside activator |
| GYG2 | glycogenin 2 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 |
| HNMT | histamine N-methyltransferase |
| IDI2-AS1 | IDI2 antisense RNA 1 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IGHM | immunoglobulin heavy constant mu |
| INPP5J | inositol polyphosphate-5-phosphatase J |
| IQCG | IQ motif containing G |
| JAK3 | Janus kinase 3 |
| JMJD4 | jumonji domain containing 4 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 |
| KLHL25 | kelch-like family member 25 |
| KRT31 | keratin 31, type I |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
| LRP12 | low density lipoprotein receptor-related protein 12 |
| LUZP1 | leucine zipper protein 1 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 |
| MANBA | mannosidase, beta A, lysosomal |
| MAP2K5 | mitogen-activated protein kinase kinase 5 |
| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 |
| MAPK7 | mitogen-activated protein kinase 7 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
| MEGF9 | multiple EGF-like-domains 9 |
| MFGE8 | milk fat globule-EGF factor 8 protein |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 |
| MYOF | myoferlin |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 |
| NEK9 | NIMA-related kinase 9 |
| NF1 | neurofibromin 1 |
| NPAS3 | neuronal PAS domain protein 3 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 |
| PARD6B | par-6 family cell polarity regulator beta |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PCNX | pecanex homolog (Drosophila) |
| PCYT1A | phosphate cytidylyltransferase 1, choline, alpha |
| PDCD2 | programmed cell death 2 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited |
| PDZD2 | PDZ domain containing 2 |
| PGAP1 | post-GPI attachment to proteins 1 |
| PLSCR3 | phospholipid scramblase 3 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 |
| PPT2 | palmitoyl-protein thioesterase 2 |
| PSD3 | pleckstrin and Sec7 domain containing 3 |
| QKI | QKI, KH domain containing, RNA binding |
| SIRT5 | sirtuin 5 |
| SMC1A | structural maintenance of chromosomes 1A |
| SMEK1 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) |
| SNAPC2 | small nuclear RNA activating complex, polypeptide 2, 45kDa |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 |
| SQSTM1 | sequestosome 1 |
| SUGP2 | SURP and G patch domain containing 2 |
| TESK1 | testis-specific kinase 1 |
| TNR | tenascin R |
| TRAPPC10 | trafficking protein particle complex 10 |
| USP34 | ubiquitin specific peptidase 34 |
| VCX2 | variable charge, X-linked 2 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) |
| WWOX | WW domain containing oxidoreductase |
| ZNF224 | zinc finger protein 224 |
| ZNF701 | zinc finger protein 701 |
| ZSCAN12 | zinc finger and SCAN domain containing 12 |
| Symbol | Name |
|---|---|
| AES | amino-terminal enhancer of split |
| AGBL5 | ATP/GTP binding protein-like 5 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like |
| ARNTL2 | aryl hydrocarbon receptor nuclear translocator-like 2 |
| ASPHD1 | aspartate beta-hydroxylase domain containing 1 |
| AXIN1 | axin 1 |
| BAHD1 | bromo adjacent homology domain containing 1 |
| C11ORF80 | chromosome 11 open reading frame 80 |
| C16ORF45 | chromosome 16 open reading frame 45 |
| C19ORF40 | chromosome 19 open reading frame 40 |
| C6ORF47 | chromosome 6 open reading frame 47 |
| CCDC85C | coiled-coil domain containing 85C |
| CISH | cytokine inducible SH2-containing protein |
| COL4A5 | collagen, type IV, alpha 5 |
| DDX54 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 |
| DOCK1 | dedicator of cytokinesis 1 |
| ELOVL4 | ELOVL fatty acid elongase 4 |
| EPHA2 | EPH receptor A2 |
| ERCC4 | excision repair cross-complementation group 4 |
| FAM188A | family with sequence similarity 188, member A |
| FBXL2 | F-box and leucine-rich repeat protein 2 |
| GAB2 | GRB2-associated binding protein 2 |
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa |
| GADD45G | growth arrest and DNA-damage-inducible, gamma |
| GLCE | glucuronic acid epimerase |
| GLS2 | glutaminase 2 (liver, mitochondrial) |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 |
| GTPBP2 | GTP binding protein 2 |
| H2AFY2 | H2A histone family, member Y2 |
| HIST1H1E | histone cluster 1, H1e |
| IFT81 | intraflagellar transport 81 |
| IGSF1 | immunoglobulin superfamily, member 1 |
| IL15RA | interleukin 15 receptor, alpha |
| KCNMB4 | potassium channel subfamily M regulatory beta subunit 4 |
| KLHL26 | kelch-like family member 26 |
| L2HGDH | L-2-hydroxyglutarate dehydrogenase |
| LAMA3 | laminin, alpha 3 |
| LIN37 | lin-37 DREAM MuvB core complex component |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 |
| MGAT1 | mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| MPST | mercaptopyruvate sulfurtransferase |
| MRPL2 | mitochondrial ribosomal protein L2 |
| MRPL52 | mitochondrial ribosomal protein L52 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric |
| NEK11 | NIMA-related kinase 11 |
| NFS1 | NFS1 cysteine desulfurase |
| NPIPB15 | nuclear pore complex interacting protein family, member B15 |
| NRGN | neurogranin (protein kinase C substrate, RC3) |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) |
| OR7E47P | olfactory receptor, family 7, subfamily E, member 47 pseudogene |
| PADI1 | peptidyl arginine deiminase, type I |
| PANX1 | pannexin 1 |
| PC | pyruvate carboxylase |
| PGP | phosphoglycolate phosphatase |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase |
| POLI | polymerase (DNA directed) iota |
| POLR3D | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa |
| POMT2 | protein-O-mannosyltransferase 2 |
| PTTG3P | pituitary tumor-transforming 3, pseudogene |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 |
| RFTN1 | raftlin, lipid raft linker 1 |
| RNF219 | ring finger protein 219 |
| RNF31 | ring finger protein 31 |
| RPL23AP7 | ribosomal protein L23a pseudogene 7 |
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) |
| SECTM1 | secreted and transmembrane 1 |
| SLC25A10 | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 |
| SLC29A3 | solute carrier family 29 (equilibrative nucleoside transporter), member 3 |
| SLC8B1 | solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
| SPIDR | scaffolding protein involved in DNA repair |
| SSFA2 | sperm specific antigen 2 |
| SULT2B1 | sulfotransferase family, cytosolic, 2B, member 1 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) |
| SYCP2 | synaptonemal complex protein 2 |
| TAGLN | transgelin |
| TDRD1 | tudor domain containing 1 |
| TMEM104 | transmembrane protein 104 |
| TMEM160 | transmembrane protein 160 |
| TMEM39B | transmembrane protein 39B |
| TPST2 | tyrosylprotein sulfotransferase 2 |
| TRAF6 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
| TRIM66 | tripartite motif containing 66 |
| TRMU | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase |
| ULBP2 | UL16 binding protein 2 |
| WLS | wntless Wnt ligand secretion mediator |
| ZC3H12A | zinc finger CCCH-type containing 12A |
| ZNF14 | zinc finger protein 14 |
| ZNF211 | zinc finger protein 211 |
| ZNF254 | zinc finger protein 254 |
| ZNF692 | zinc finger protein 692 |
| ZNF787 | zinc finger protein 787 |
| ZYX | zyxin |
