dorzolamide-6142 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the dorzolamide-6142 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADGB androglobin
AFF2 AF4/FMR2 family, member 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
ARR3 arrestin 3, retinal (X-arrestin)
BEST1 bestrophin 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CD6 CD6 molecule
CHPF chondroitin polymerizing factor
CLCA1 chloride channel accessory 1
CLDN7 claudin 7
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL1A2 collagen, type I, alpha 2
CTC1 CTS telomere maintenance complex component 1
CTTN cortactin
CYLD cylindromatosis (turban tumor syndrome)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DOPEY1 dopey family member 1
DRD2 dopamine receptor D2
EIF3F eukaryotic translation initiation factor 3, subunit F
ESR1 estrogen receptor 1
EXOSC2 exosome component 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GPC1 glypican 1
GPC4 glypican 4
GPR75 G protein-coupled receptor 75
GRIK2 glutamate receptor, ionotropic, kainate 2
GRM7 glutamate receptor, metabotropic 7
HOMER2 homer scaffolding protein 2
HOXB2 homeobox B2
IDS iduronate 2-sulfatase
IFNB1 interferon, beta 1, fibroblast
IL12B interleukin 12B
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2
KDR kinase insert domain receptor
KIF1C kinesin family member 1C
KIF5C kinesin family member 5C
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KYNU kynureninase
LPAR1 lysophosphatidic acid receptor 1
LY6D lymphocyte antigen 6 complex, locus D
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MERTK MER proto-oncogene, tyrosine kinase
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MIR22HG MIR22 host gene
MSX2 msh homeobox 2
MTSS1 metastasis suppressor 1
MYCNOS MYCN opposite strand
NCAM1 neural cell adhesion molecule 1
NF2 neurofibromin 2 (merlin)
NFIB nuclear factor I/B
NMT2 N-myristoyltransferase 2
NOS1 nitric oxide synthase 1 (neuronal)
NR0B1 nuclear receptor subfamily 0, group B, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDPN podoplanin
PER1 period circadian clock 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRR5 proline rich 5 (renal)
RBM12B RNA binding motif protein 12B
REPS1 RALBP1 associated Eps domain containing 1
RNF19B ring finger protein 19B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A5 S100 calcium binding protein A5
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BP1 SH3-domain binding protein 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLURP1 secreted LY6/PLAUR domain containing 1
SNW1 SNW domain containing 1
SPRR1A small proline-rich protein 1A
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STS steroid sulfatase (microsomal), isozyme S
TCF20 transcription factor 20 (AR1)
TCF3 transcription factor 3
TESPA1 thymocyte expressed, positive selection associated 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFCP2L1 transcription factor CP2-like 1
TMEM132A transmembrane protein 132A
TMEM51 transmembrane protein 51
TMPRSS5 transmembrane protease, serine 5
TP53TG1 TP53 target 1 (non-protein coding)
TPMT thiopurine S-methyltransferase
TROVE2 TROVE domain family, member 2
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
UGT8 UDP glycosyltransferase 8
WWC1 WW and C2 domain containing 1
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARL15 ADP-ribosylation factor-like 15
ARRB1 arrestin, beta 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BSG basigin (Ok blood group)
C8ORF44 chromosome 8 open reading frame 44
CAMKMT calmodulin-lysine N-methyltransferase
CAPN5 calpain 5
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC37 cell division cycle 37
CEP295 centrosomal protein 295kDa
CEP97 centrosomal protein 97kDa
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
EDC3 enhancer of mRNA decapping 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EML4 echinoderm microtubule associated protein like 4
ENO2 enolase 2 (gamma, neuronal)
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FKBP5 FK506 binding protein 5
FKBP9 FK506 binding protein 9, 63 kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALK1 galactokinase 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR22 G protein-coupled receptor 22
GTF2I general transcription factor IIi
HIRA histone cell cycle regulator
HIST1H2BN histone cluster 1, H2bn
INO80D INO80 complex subunit D
IPO8 importin 8
IREB2 iron-responsive element binding protein 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LOC390998 ribosomal protein L10 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MCRS1 microspherule protein 1
MDM4 MDM4, p53 regulator
MED18 mediator complex subunit 18
METRN meteorin, glial cell differentiation regulator
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGD phosphogluconate dehydrogenase
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G15 phospholipase A2, group XV
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POM121L2 POM121 transmembrane nucleoporin-like 2
PRR3 proline rich 3
PSAT1 phosphoserine aminotransferase 1
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PYGB phosphorylase, glycogen; brain
R3HCC1L R3H domain and coiled-coil containing 1-like
RASAL1 RAS protein activator like 1 (GAP1 like)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
SCAI suppressor of cancer cell invasion
SCYL2 SCY1-like 2 (S. cerevisiae)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMG9 SMG9 nonsense mediated mRNA decay factor
SNRPN small nuclear ribonucleoprotein polypeptide N
STK16 serine/threonine kinase 16
SYNC syncoilin, intermediate filament protein
TEC tec protein tyrosine kinase
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR8 toll-like receptor 8
TMEM120B transmembrane protein 120B
TRIM25 tripartite motif containing 25
TSPYL2 TSPY-like 2
TXLNG taxilin gamma
UNC119 unc-119 homolog (C. elegans)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YIPF5 Yip1 domain family, member 5
ZBTB38 zinc finger and BTB domain containing 38
ZMAT5 zinc finger, matrin-type 5
ZNF137P zinc finger protein 137, pseudogene
ZNF428 zinc finger protein 428
ZNF493 zinc finger protein 493
ZNF665 zinc finger protein 665
ZNF675 zinc finger protein 675