dopaminergic system Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The system of nerve cells that uses dopamine as its neurotransmitter. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003954)
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Genes

180 proteins co-occuring with the tissue dopaminergic system in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
DRD2 dopamine receptor D2 2.77827
TH tyrosine hydroxylase 2.68366
DRD4 dopamine receptor D4 2.41529
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.16973
COMT catechol-O-methyltransferase 2.11073
DRD3 dopamine receptor D3 2.03375
DRD5 dopamine receptor D5 1.90654
SAP25 Sin3A-associated protein, 25kDa 1.85534
DRD1 dopamine receptor D1 1.73579
PRL prolactin 1.65607
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.63606
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.59473
MAOB monoamine oxidase B 1.55843
MAOA monoamine oxidase A 1.49067
GDNF glial cell derived neurotrophic factor 1.46635
ANKK1 ankyrin repeat and kinase domain containing 1 1.43801
NTS neurotensin 1.43431
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.37134
TRH thyrotropin-releasing hormone 1.34678
POMC proopiomelanocortin 1.28636
FOS FBJ murine osteosarcoma viral oncogene homolog 1.26397
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.24476
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.17802
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.16959
PITX3 paired-like homeodomain 3 1.16338
BDNF brain-derived neurotrophic factor 1.15628
PDYN prodynorphin 1.15096
DAD1 defender against cell death 1 1.14653
GCH1 GTP cyclohydrolase 1 1.12837
OPRM1 opioid receptor, mu 1 1.05941
TOR1B torsin family 1, member B (torsin B) 1.03829
CNR1 cannabinoid receptor 1 (brain) 1.03741
IGKV1-17 immunoglobulin kappa variable 1-17 1.03609
TPH1 tryptophan hydroxylase 1 1.01243
TAAR1 trace amine associated receptor 1 0.990204
BTBD9 BTB (POZ) domain containing 9 0.952116
TAC1 tachykinin, precursor 1 0.951685
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.926764
OTP orthopedia homeobox 0.901147
DARS aspartyl-tRNA synthetase 0.898595
CCK cholecystokinin 0.890101
NPS neuropeptide S 0.844126
CRH corticotropin releasing hormone 0.842027
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.832385
PENK proenkephalin 0.831966
ACHE acetylcholinesterase (Yt blood group) 0.82736
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.818994
REN renin 0.813562
LRRK2 leucine-rich repeat kinase 2 0.797291
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.796458
GPR6 G protein-coupled receptor 6 0.773589
GFRAL GDNF family receptor alpha like 0.760328
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 0.754124
GRK4 G protein-coupled receptor kinase 4 0.747515
TOR1A torsin family 1, member A (torsin A) 0.695354
PSENEN presenilin enhancer gamma secretase subunit 0.691268
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.680656
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.67984
CCKBR cholecystokinin B receptor 0.67984
DGCR6 DiGeorge syndrome critical region gene 6 0.676987
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.667215
CORT cortistatin 0.665995
CNRIP1 cannabinoid receptor interacting protein 1 0.649749
DGCR2 DiGeorge syndrome critical region gene 2 0.644479
SKOR1 SKI family transcriptional corepressor 1 0.635167
ADCY2 adenylate cyclase 2 (brain) 0.633953
INTS8 integrator complex subunit 8 0.631931
CREB1 cAMP responsive element binding protein 1 0.629101
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 0.627889
NGF nerve growth factor (beta polypeptide) 0.621831
CCKAR cholecystokinin A receptor 0.591641
ZDHHC8 zinc finger, DHHC-type containing 8 0.590839
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.576415
CDSN corneodesmosin 0.568823
MCHR1 melanin-concentrating hormone receptor 1 0.561644
GPX1 glutathione peroxidase 1 0.552888
CHAT choline O-acetyltransferase 0.546533
SEC24D SEC24 family member D 0.537021
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 0.533065
GRM2 glutamate receptor, metabotropic 2 0.530693
HCRT hypocretin (orexin) neuropeptide precursor 0.528719
PORCN porcupine homolog (Drosophila) 0.528323
BCHE butyrylcholinesterase 0.512171
SOD2 superoxide dismutase 2, mitochondrial 0.50079
GPX5 glutathione peroxidase 5 0.496092
NAT8L N-acetyltransferase 8-like (GCN5-related, putative) 0.495309
GPX4 glutathione peroxidase 4 0.492182
SST somatostatin 0.489838
GPR88 G protein-coupled receptor 88 0.488276
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.486716
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.486326
RNF17 ring finger protein 17 0.485545
MANF mesencephalic astrocyte-derived neurotrophic factor 0.477367
PER2 period circadian clock 2 0.47348
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.471151
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.468824
TMEM245 transmembrane protein 245 0.468824
NPY neuropeptide Y 0.460692
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.442194
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.440658
GRP gastrin-releasing peptide 0.431843
NPSR1 neuropeptide S receptor 1 0.431843
FAAH fatty acid amide hydrolase 0.427254
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.419242
CAT catalase 0.416576
PTK7 protein tyrosine kinase 7 (inactive) 0.413912
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.412011
SYCN syncollin 0.410111
SNCB synuclein, beta 0.409351
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.408972
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.407073
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.402523
PDE10A phosphodiesterase 10A 0.40025
MAP2K5 mitogen-activated protein kinase kinase 5 0.396465
PARK2 parkin RBR E3 ubiquitin protein ligase 0.389289
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.388158
ACE angiotensin I converting enzyme 0.38665
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.384013
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.38326
PNOC prepronociceptin 0.379123
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.373493
AGA aspartylglucosaminidase 0.373118
INS insulin 0.368624
NRG1 neuregulin 1 0.362646
ADGRL3 adhesion G protein-coupled receptor L3 0.361155
HCRTR2 hypocretin (orexin) receptor 2 0.361155
CARTPT CART prepropeptide 0.360409
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.354826
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.353712
NTF4 neurotrophin 4 0.350372
SNX1 sorting nexin 1 0.346668
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.34371
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.341863
RPL4 ribosomal protein L4 0.338177
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.330094
AVP arginine vasopressin 0.329727
MEIS1 Meis homeobox 1 0.329361
LMX1B LIM homeobox transcription factor 1, beta 0.327164
CCDC27 coiled-coil domain containing 27 0.324605
MIR212 microRNA 212 0.323144
MIRLET7D microRNA let-7d 0.322779
ADORA2A adenosine A2a receptor 0.321685
CDNF cerebral dopamine neurotrophic factor 0.314409
CPZ carboxypeptidase Z 0.31332
SDPR serum deprivation response 0.305001
HSPB2 heat shock 27kDa protein 2 0.304279
ACPT acid phosphatase, testicular 0.302838
CALY calcyon neuron-specific vesicular protein 0.294223
SYP synaptophysin 0.286381
CALB1 calbindin 1, 28kDa 0.282483
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.280364
ZNF804A zinc finger protein 804A 0.276495
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.275794
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.270214
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.266757
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.266757
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.265381
RELN reelin 0.263669
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.250301
WRAP73 WD repeat containing, antisense to TP73 0.245807
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.240216
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.239307
MECP2 methyl CpG binding protein 2 0.237216
HMOX1 heme oxygenase 1 0.235457
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.23459
ARRB2 arrestin, beta 2 0.232881
EN1 engrailed homeobox 1 0.23176
ADRA2A adrenoceptor alpha 2A 0.226411
ATXN3 ataxin 3 0.224398
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.222699
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.22246
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.221061
MAPT microtubule-associated protein tau 0.220831
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.219485
PDE2A phosphodiesterase 2A, cGMP-stimulated 0.219485
CARS cysteinyl-tRNA synthetase 0.219047
NPPA natriuretic peptide A 0.219047
PVALB parvalbumin 0.219047
TACR3 tachykinin receptor 3 0.217554
NRTN neurturin 0.213471