domperidone-4640 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the domperidone-4640 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
ADRB3 adrenoceptor beta 3
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGAP26 Rho GTPase activating protein 26
BBC3 BCL2 binding component 3
BICC1 BicC family RNA binding protein 1
BIRC3 baculoviral IAP repeat containing 3
BRWD1 bromodomain and WD repeat domain containing 1
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
CD4 CD4 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CLCN6 chloride channel, voltage-sensitive 6
COBL cordon-bleu WH2 repeat protein
COL3A1 collagen, type III, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH3 cytohesin 3
DDIT3 DNA-damage-inducible transcript 3
DICER1 dicer 1, ribonuclease type III
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM134B family with sequence similarity 134, member B
FBXL7 F-box and leucine-rich repeat protein 7
GADD45B growth arrest and DNA-damage-inducible, beta
GLRA3 glycine receptor, alpha 3
GPR137 G protein-coupled receptor 137
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HEG1 heart development protein with EGF-like domains 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXD1 homeobox D1
ICAM1 intercellular adhesion molecule 1
IL6 interleukin 6
INO80B INO80 complex subunit B
KIF25 kinesin family member 25
LIF leukemia inhibitory factor
LIMD2 LIM domain containing 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LYRM9 LYR motif containing 9
MEF2D myocyte enhancer factor 2D
MMP11 matrix metallopeptidase 11
MUC3A mucin 3A, cell surface associated
NAV3 neuron navigator 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NF2 neurofibromin 2 (merlin)
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN3 neurexin 3
PAX2 paired box 2
PCNX pecanex homolog (Drosophila)
PDGFB platelet-derived growth factor beta polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
RBBP9 retinoblastoma binding protein 9
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS7 regulator of G-protein signaling 7
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SCAND2P SCAN domain containing 2 pseudogene
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK2 serum/glucocorticoid regulated kinase 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SP1 Sp1 transcription factor
SPEG SPEG complex locus
SQLE squalene epoxidase
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STC2 stanniocalcin 2
STX7 syntaxin 7
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAPBP TAP binding protein (tapasin)
TDRD1 tudor domain containing 1
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
UNC93B1 unc-93 homolog B1 (C. elegans)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAV2 vav 2 guanine nucleotide exchange factor
WT1 Wilms tumor 1
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRE2 adhesion G protein-coupled receptor E2
AKR1C4 aldo-keto reductase family 1, member C4
ARMCX4 armadillo repeat containing, X-linked 4
ARPIN actin-related protein 2/3 complex inhibitor
ASAP1-IT1 ASAP1 intronic transcript 1
ASTN1 astrotactin 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP15 bone morphogenetic protein 15
C17ORF80 chromosome 17 open reading frame 80
C8A complement component 8, alpha polypeptide
CCP110 centriolar coiled coil protein 110kDa
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK20 cyclin-dependent kinase 20
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CGA glycoprotein hormones, alpha polypeptide
CIDEC cell death-inducing DFFA-like effector c
CLDN17 claudin 17
CLIC3 chloride intracellular channel 3
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTLN centlein, centrosomal protein
CNTNAP3B contactin associated protein-like 3B
CSAD cysteine sulfinic acid decarboxylase
CST4 cystatin S
DNALI1 dynein, axonemal, light intermediate chain 1
DUSP8 dual specificity phosphatase 8
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FGG fibrinogen gamma chain
FILIP1L filamin A interacting protein 1-like
FLCN folliculin
FMO4 flavin containing monooxygenase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMPD1 FERM and PDZ domain containing 1
GAS8 growth arrest-specific 8
GRTP1 growth hormone regulated TBC protein 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HIPK2 homeodomain interacting protein kinase 2
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AL histone cluster 1, H2al
IFT140 intraflagellar transport 140
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL12RB1 interleukin 12 receptor, beta 1
IREB2 iron-responsive element binding protein 2
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0513 KIAA0513
KRT20 keratin 20, type I
LINC00597 long intergenic non-protein coding RNA 597
LMCD1 LIM and cysteine-rich domains 1
LOC100272216 uncharacterized LOC100272216
LYPD3 LY6/PLAUR domain containing 3
MBTD1 mbt domain containing 1
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDP Norrie disease (pseudoglioma)
NEUROD4 neuronal differentiation 4
NNAT neuronatin
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRN1 neuritin 1
NTF3 neurotrophin 3
PALMD palmdelphin
PCDHB13 protocadherin beta 13
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAG1 pleiomorphic adenoma gene 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRICKLE3 prickle homolog 3 (Drosophila)
PSORS1C1 psoriasis susceptibility 1 candidate 1
RGR retinal G protein coupled receptor
RIBC2 RIB43A domain with coiled-coils 2
RIMBP2 RIMS binding protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
SAA4 serum amyloid A4, constitutive
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SOX21 SRY (sex determining region Y)-box 21
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF15 transcription factor 15 (basic helix-loop-helix)
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM212 transmembrane protein 212
TMEM53 transmembrane protein 53
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA3D tubulin, alpha 3d
WDR78 WD repeat domain 78
ZNF141 zinc finger protein 141
ZNF197 zinc finger protein 197
ZNF768 zinc finger protein 768