dna-directed rna polymerase ii, holoenzyme Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. (Gene Ontology, GO_0016591)
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175 proteins co-occuring with the dna-directed rna polymerase ii, holoenzyme cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.31607
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.08817
CDC73 cell division cycle 73 2.03724
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.95442
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 1.20189
HIST1H2BH histone cluster 1, H2bh 1.18492
HIST2H2BF histone cluster 2, H2bf 1.18492
HIST3H2BB histone cluster 3, H2bb 1.18492
HIST1H2BD histone cluster 1, H2bd 1.1844
HIST1H2BF histone cluster 1, H2bf 1.18286
HIST1H2BC histone cluster 1, H2bc 1.18286
HIST1H2BA histone cluster 1, H2ba 1.18132
INTS6 integrator complex subunit 6 1.03829
CDK8 cyclin-dependent kinase 8 1.02181
SETD1A SET domain containing 1A 1.00054
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.945432
H3F3B H3 histone, family 3B (H3.3B) 0.941162
H3F3A H3 histone, family 3A 0.941162
RPAP2 RNA polymerase II associated protein 2 0.881477
INTS7 integrator complex subunit 7 0.866287
CREBBP CREB binding protein 0.857555
INTS12 integrator complex subunit 12 0.844696
INTS1 integrator complex subunit 1 0.828171
CCNC cyclin C 0.819911
HIPK4 homeodomain interacting protein kinase 4 0.805689
INTS4 integrator complex subunit 4 0.802021
MED12 mediator complex subunit 12 0.793771
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.751357
SETD2 SET domain containing 2 0.742769
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 0.739163
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 0.734666
MIR192 microRNA 192 0.730628
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.713682
CHD1 chromodomain helicase DNA binding protein 1 0.712351
CPSF3L cleavage and polyadenylation specific factor 3-like 0.710136
INTS3 integrator complex subunit 3 0.686827
INTS5 integrator complex subunit 5 0.681155
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.669858
INIP INTS3 and NABP interacting protein 0.665096
SLC39A3 solute carrier family 39 (zinc transporter), member 3 0.646145
IL19 interleukin 19 0.602331
TRIP4 thyroid hormone receptor interactor 4 0.600223
SESTD1 SEC14 and spectrin domains 1 0.587618
CDK19 cyclin-dependent kinase 19 0.575912
NCOA1 nuclear receptor coactivator 1 0.564262
MED13 mediator complex subunit 13 0.563017
INTS9 integrator complex subunit 9 0.538649
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.521841
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.518165
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.517348
MED17 mediator complex subunit 17 0.510011
SLC6A16 solute carrier family 6, member 16 0.500664
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.490944
RANBP10 RAN binding protein 10 0.487307
WNK3 WNK lysine deficient protein kinase 3 0.482064
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 0.469604
MED16 mediator complex subunit 16 0.465598
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.465198
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 0.460001
STK16 serine/threonine kinase 16 0.458803
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 0.456012
LHX9 LIM homeobox 9 0.450438
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 0.449643
FOXE3 forkhead box E3 0.448848
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.435775
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.433801
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 0.426711
OSBP2 oxysterol binding protein 2 0.424353
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.419252
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.414555
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 0.412601
TRRAP transformation/transcription domain-associated protein 0.405971
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.401693
RGS9BP regulator of G protein signaling 9 binding protein 0.397035
OSBPL8 oxysterol binding protein-like 8 0.39626
GSTK1 glutathione S-transferase kappa 1 0.395873
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.395873
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.395098
GPBAR1 G protein-coupled bile acid receptor 1 0.393549
GJB5 gap junction protein, beta 5, 31.1kDa 0.391228
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.390841
JAG2 jagged 2 0.390841
CCAR2 cell cycle and apoptosis regulator 2 0.390455
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa 0.389296
OSBPL3 oxysterol binding protein-like 3 0.388137
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.387751
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.385822
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.383895
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.383895
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 0.381969
MED15 mediator complex subunit 15 0.37966
CARM1 coactivator-associated arginine methyltransferase 1 0.378891
PCP2 Purkinje cell protein 2 0.371599
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 0.371599
ELF5 E74-like factor 5 (ets domain transcription factor) 0.371599
HIPK1 homeodomain interacting protein kinase 1 0.365859
DICER1 dicer 1, ribonuclease type III 0.364331
WDR61 WD repeat domain 61 0.362804
NPW neuropeptide W 0.362804
CDK9 cyclin-dependent kinase 9 0.360133
NABP2 nucleic acid binding protein 2 0.354802
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.352522
VIP vasoactive intestinal peptide 0.349484
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.345314
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.341907
PHF6 PHD finger protein 6 0.341151
G6PC2 glucose-6-phosphatase, catalytic, 2 0.323825
RANBP9 RAN binding protein 9 0.318953
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.31783
AFF1 AF4/FMR2 family, member 1 0.31783
MIR21 microRNA 21 0.315586
ADORA2B adenosine A2b receptor 0.312597
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.30626
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.303655
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.303655
G6PC3 glucose 6 phosphatase, catalytic, 3 0.299197
PYCR1 pyrroline-5-carboxylate reductase 1 0.297342
TRAPPC10 trafficking protein particle complex 10 0.287721
HIPK3 homeodomain interacting protein kinase 3 0.287352
TUBG1 tubulin, gamma 1 0.285876
KAT2B K(lysine) acetyltransferase 2B 0.285507
RGS7BP regulator of G-protein signaling 7 binding protein 0.284769
AFF4 AF4/FMR2 family, member 4 0.284032
TPSG1 tryptase gamma 1 0.276304
SFTPA2 surfactant protein A2 0.271533
SMAD5 SMAD family member 5 0.271167
TADA3 transcriptional adaptor 3 0.270434
ZFP36 ZFP36 ring finger protein 0.266408
CLCNKB chloride channel, voltage-sensitive Kb 0.262025
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.258016
LHX2 LIM homeobox 2 0.254743
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.251839
RBBP9 retinoblastoma binding protein 9 0.249664
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.248216
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.247854
TP53 tumor protein p53 0.247854
ANKK1 ankyrin repeat and kinase domain containing 1 0.244962
MAF1 MAF1 homolog (S. cerevisiae) 0.242437
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.233817
FOXO1 forkhead box O1 0.229532
SHD Src homology 2 domain containing transforming protein D 0.225976
CYTH2 cytohesin 2 0.22279
GAS1 growth arrest-specific 1 0.222083
CRH corticotropin releasing hormone 0.220321
NPY neuropeptide Y 0.218914
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.217511
PEG3 paternally expressed 3 0.215761
NANOG Nanog homeobox 0.206082
CDX1 caudal type homeobox 1 0.197662
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.193394
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.190495
EOMES eomesodermin 0.190495
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.186087
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.184547
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.180339
WNK4 WNK lysine deficient protein kinase 4 0.178011
BIK BCL2-interacting killer (apoptosis-inducing) 0.177439
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.171673
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.169604
CDK11A cyclin-dependent kinase 11A 0.168349
TBP TATA box binding protein 0.167125
XPO5 exportin 5 0.166884
CCNH cyclin H 0.166405
DRD2 dopamine receptor D2 0.165
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.164089
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.1632
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.16233
PIF1 PIF1 5'-to-3' DNA helicase 0.16233
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.161484
SMAD9 SMAD family member 9 0.161068
LMX1B LIM homeobox transcription factor 1, beta 0.160658
FOS FBJ murine osteosarcoma viral oncogene homolog 0.160456
CCR2 chemokine (C-C motif) receptor 2 0.159462
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.159462
CDK4 cyclin-dependent kinase 4 0.159462