dna replication preinitiation complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. (Gene Ontology, GO_0031261)
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55 proteins co-occuring with the dna replication preinitiation complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDC45 cell division cycle 45 2.92846
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.4717
MCM2 minichromosome maintenance complex component 2 2.21116
MCM7 minichromosome maintenance complex component 7 2.20892
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.20445
WDHD1 WD repeat and HMG-box DNA binding protein 1 1.51074
MCM10 minichromosome maintenance complex component 10 1.49944
TICRR TOPBP1-interacting checkpoint and replication regulator 1.48645
BOLL boule-like RNA-binding protein 1.31465
RECQL4 RecQ protein-like 4 1.12858
TOPBP1 topoisomerase (DNA) II binding protein 1 1.11582
MUT methylmalonyl CoA mutase 1.01139
MCM4 minichromosome maintenance complex component 4 1.00202
CDT1 chromatin licensing and DNA replication factor 1 0.951619
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.936432
CDC7 cell division cycle 7 0.879173
DHH desert hedgehog 0.846073
RNASEH2B ribonuclease H2, subunit B 0.785071
PCNA proliferating cell nuclear antigen 0.779126
CDC6 cell division cycle 6 0.71457
DBF4 DBF4 zinc finger 0.705273
TIPIN TIMELESS interacting protein 0.695587
MCM5 minichromosome maintenance complex component 5 0.617557
DERA deoxyribose-phosphate aldolase (putative) 0.608663
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.599381
MCM6 minichromosome maintenance complex component 6 0.58678
LINS lines homolog (Drosophila) 0.574662
NCOA4 nuclear receptor coactivator 4 0.564677
KLF11 Kruppel-like factor 11 0.530438
UBIAD1 UbiA prenyltransferase domain containing 1 0.465598
DLX1 distal-less homeobox 1 0.439728
ZNF384 zinc finger protein 384 0.423567
ATAD5 ATPase family, AAA domain containing 5 0.392388
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.380429
MRC1 mannose receptor, C type 1 0.363185
FANCF Fanconi anemia, complementation group F 0.337751
RNASEH1 ribonuclease H1 0.336241
CAPN10 calpain 10 0.327205
CHEK1 checkpoint kinase 1 0.323075
MON1A MON1 secretory trafficking family member A 0.306632
EPGN epithelial mitogen 0.300311
E2F1 E2F transcription factor 1 0.2708
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.26385
CLSPN claspin 0.251114
FANCI Fanconi anemia, complementation group I 0.242437
PAPD7 PAP associated domain containing 7 0.241356
TIMELESS timeless circadian clock 0.225622
DNA2 DNA replication helicase/nuclease 2 0.191777
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.189222
CA6 carbonic anhydrase VI 0.167366
MUS81 MUS81 structure-specific endonuclease subunit 0.16298
DNAH8 dynein, axonemal, heavy chain 8 0.157578
MCM3 minichromosome maintenance complex component 3 0.157218
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.133858
RPA2 replication protein A2, 32kDa 0.128213