dna replication factor a complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. (Gene Ontology, GO_0005662)
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203 proteins co-occuring with the dna replication factor a complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TRIM21 tripartite motif containing 21 2.23372
RPA2 replication protein A2, 32kDa 2.2149
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 2.03289
RPA1 replication protein A1, 70kDa 2.02999
RAD51 RAD51 recombinase 1.84703
RFC1 replication factor C (activator 1) 1, 145kDa 1.83338
RFC4 replication factor C (activator 1) 4, 37kDa 1.81579
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.80106
RFC3 replication factor C (activator 1) 3, 38kDa 1.78913
XPA xeroderma pigmentosum, complementation group A 1.78781
RFC2 replication factor C (activator 1) 2, 40kDa 1.77861
RAD52 RAD52 homolog (S. cerevisiae) 1.73309
PCNA proliferating cell nuclear antigen 1.69891
CHEK1 checkpoint kinase 1 1.65453
ATM ATM serine/threonine kinase 1.56275
ATRIP ATR interacting protein 1.51017
FEN1 flap structure-specific endonuclease 1 1.49097
DNA2 DNA replication helicase/nuclease 2 1.48984
WRN Werner syndrome, RecQ helicase-like 1.47061
RPA3 replication protein A3, 14kDa 1.45307
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.30228
TROVE2 TROVE domain family, member 2 1.29639
ATR ATR serine/threonine kinase 1.28623
EXO1 exonuclease 1 1.26762
SSB Sjogren syndrome antigen B (autoantigen La) 1.25127
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.23557
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.2086
PURB purine-rich element binding protein B 1.20756
RPA4 replication protein A4, 30kDa 1.19057
TOP1 topoisomerase (DNA) I 1.17465
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.16338
RECQL RecQ helicase-like 1.15109
LIG1 ligase I, DNA, ATP-dependent 1.1296
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 1.11225
ERCC5 excision repair cross-complementation group 5 1.06498
RAD9A RAD9 homolog A (S. pombe) 1.05791
PLAT plasminogen activator, tissue 1.05035
NABP2 nucleic acid binding protein 2 1.03279
RAD17 RAD17 homolog (S. pombe) 1.00843
RMI1 RecQ mediated genome instability 1 1.00744
CLSPN claspin 1.00054
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.98683
TP53 tumor protein p53 0.973714
H2AFX H2A histone family, member X 0.973714
ERCC4 excision repair cross-complementation group 4 0.966474
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.948284
TIPIN TIMELESS interacting protein 0.944007
BRCA2 breast cancer 2, early onset 0.942584
ERCC1 excision repair cross-complementation group 1 0.934544
XPC xeroderma pigmentosum, complementation group C 0.919982
PAPD7 PAP associated domain containing 7 0.896257
SP100 SP100 nuclear antigen 0.892093
HSPG2 heparan sulfate proteoglycan 2 0.878251
HSPA4 heat shock 70kDa protein 4 0.851583
TOPBP1 topoisomerase (DNA) II binding protein 1 0.849287
BLM Bloom syndrome, RecQ helicase-like 0.848828
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.825418
MLH1 mutL homolog 1 0.808441
RAD23B RAD23 homolog B (S. cerevisiae) 0.782784
RFWD3 ring finger and WD repeat domain 3 0.776384
RAD50 RAD50 homolog (S. cerevisiae) 0.773645
RECQL4 RecQ protein-like 4 0.760433
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.748189
AICDA activation-induced cytidine deaminase 0.745025
POLL polymerase (DNA directed), lambda 0.745025
HELB helicase (DNA) B 0.725705
SERTAD3 SERTA domain containing 3 0.725705
TICAM2 toll-like receptor adaptor molecule 2 0.71946
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.712351
BRCA1 breast cancer 1, early onset 0.711022
SSBP3 single stranded DNA binding protein 3 0.709693
RMI2 RecQ mediated genome instability 2 0.699103
RAD18 RAD18 E3 ubiquitin protein ligase 0.69427
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.691202
POT1 protection of telomeres 1 0.68639
CDK2 cyclin-dependent kinase 2 0.668559
PPAN peter pan homolog (Drosophila) 0.668559
CDC45 cell division cycle 45 0.638861
HUS1 HUS1 checkpoint homolog (S. pombe) 0.636723
MSH2 mutS homolog 2 0.62393
UNG uracil-DNA glycosylase 0.61968
PRPH peripherin 0.618406
TOP3A topoisomerase (DNA) III alpha 0.60444
HLTF helicase-like transcription factor 0.586361
RPAIN RPA interacting protein 0.577581
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.565092
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.556387
CD79A CD79a molecule, immunoglobulin-associated alpha 0.551838
PIF1 PIF1 5'-to-3' DNA helicase 0.548122
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.546885
RNF4 ring finger protein 4 0.537827
POLH polymerase (DNA directed), eta 0.522659
NABP1 nucleic acid binding protein 1 0.518165
LIG3 ligase III, DNA, ATP-dependent 0.514085
REV1 REV1, polymerase (DNA directed) 0.509197
SPO11 SPO11 meiotic protein covalently bound to DSB 0.487711
RPAP1 RNA polymerase II associated protein 1 0.485693
PLG plasminogen 0.481661
KCTD5 potassium channel tetramerization domain containing 5 0.470406
CTC1 CTS telomere maintenance complex component 1 0.455613
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.448054
MSH4 mutS homolog 4 0.439333
LIG4 ligase IV, DNA, ATP-dependent 0.43617
MDC1 mediator of DNA-damage checkpoint 1 0.434985
OR13H1 olfactory receptor, family 13, subfamily H, member 1 0.431041
SPAG11A sperm associated antigen 11A 0.429859
KLHL7 kelch-like family member 7 0.429072
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.426318
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.41612
CENPB centromere protein B, 80kDa 0.409869
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.409479
SPAG11B sperm associated antigen 11B 0.404026
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.400139
RECQL5 RecQ protein-like 5 0.398199
SPATA22 spermatogenesis associated 22 0.393162
MLH3 mutL homolog 3 0.392388
POLB polymerase (DNA directed), beta 0.385436
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.370067
SUB1 SUB1 homolog (S. cerevisiae) 0.370067
TRH thyrotropin-releasing hormone 0.367771
NCL nucleolin 0.362422
BCAS2 breast carcinoma amplified sequence 2 0.356705
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.353282
GPR132 G protein-coupled receptor 132 0.348346
CDK1 cyclin-dependent kinase 1 0.346829
LDB1 LIM domain binding 1 0.343799
HELQ helicase, POLQ-like 0.341907
TMEM11 transmembrane protein 11 0.338884
FANCD2 Fanconi anemia, complementation group D2 0.338128
ZNF77 zinc finger protein 77 0.336996
USP1 ubiquitin specific peptidase 1 0.333979
TCTA T-cell leukemia translocation altered 0.330966
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.329461
A2M alpha-2-macroglobulin 0.327956
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.326829
PALB2 partner and localizer of BRCA2 0.325702
IL17C interleukin 17C 0.320826
SSBP2 single-stranded DNA binding protein 2 0.314839
MRC1 mannose receptor, C type 1 0.312597
FUBP3 far upstream element (FUSE) binding protein 3 0.30924
SERTAD1 SERTA domain containing 1 0.308494
SETD8 SET domain containing (lysine methyltransferase) 8 0.305143
RNASEH1 ribonuclease H1 0.301054
HIAT1 hippocampus abundant transcript 1 0.29994
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.294378
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.282558
YBX1 Y box binding protein 1 0.281453
FOS FBJ murine osteosarcoma viral oncogene homolog 0.278877
BTNL2 butyrophilin-like 2 0.277406
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.276304
NANS N-acetylneuraminic acid synthase 0.275569
UIMC1 ubiquitin interaction motif containing 1 0.275202
POLM polymerase (DNA directed), mu 0.274101
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.266408
KLHL12 kelch-like family member 12 0.263485
PRTN3 proteinase 3 0.26312
MCM8 minichromosome maintenance complex component 8 0.262755
IFI16 interferon, gamma-inducible protein 16 0.260566
PLRG1 pleiotropic regulator 1 0.259473
MCMBP minichromosome maintenance complex binding protein 0.250026
HAUS3 HAUS augmin-like complex, subunit 3 0.249302
NBN nibrin 0.249302
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.24894
NLRP5 NLR family, pyrin domain containing 5 0.247492
CDK7 cyclin-dependent kinase 7 0.238478
RLIM ring finger protein, LIM domain interacting 0.237042
WDR11 WD repeat domain 11 0.235966
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.232744
CDA cytidine deaminase 0.232029
GALK1 galactokinase 1 0.231672
TRIM24 tripartite motif containing 24 0.227041
CDC7 cell division cycle 7 0.225622
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.22173
RPL23 ribosomal protein L23 0.217511
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.213322
ATAD3C ATPase family, AAA domain containing 3C 0.212627
SYCP1 synaptonemal complex protein 1 0.211587
LCT lactase 0.203699
PARP1 poly (ADP-ribose) polymerase 1 0.200999
MSH3 mutS homolog 3 0.200663
CALR calreticulin 0.190175
RPAP3 RNA polymerase II associated protein 3 0.189857
C4A complement component 4A (Rodgers blood group) 0.189539
MSH6 mutS homolog 6 0.184547
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.181823
ADAT2 adenosine deaminase, tRNA-specific 2 0.181823
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.181823
SENP6 SUMO1/sentrin specific peptidase 6 0.181227
TIMELESS timeless circadian clock 0.181227
DSCC1 DNA replication and sister chromatid cohesion 1 0.18093
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.180045
PASK PAS domain containing serine/threonine kinase 0.177154
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.175188
DNAH8 dynein, axonemal, heavy chain 8 0.170888
RAD51D RAD51 paralog D 0.170371
RPL39 ribosomal protein L39 0.170114
RBBP8 retinoblastoma binding protein 8 0.169604
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.169099
STK39 serine threonine kinase 39 0.167125
PML promyelocytic leukemia 0.165697
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.165463
TPH1 tryptophan hydroxylase 1 0.165463
CSN2 casein beta 0.159268