dna repair Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. (Gene Ontology, GO_0006281)
External Link http://amigo.geneontology.org/amigo/term/GO:0006281
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Genes

391 genes participating in the dna repair biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTL6A actin-like 6A
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APLF aprataxin and PNKP like factor
APTX aprataxin
ASF1A anti-silencing function 1A histone chaperone
ASTE1 asteroid homolog 1 (Drosophila)
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
ATRX alpha thalassemia/mental retardation syndrome X-linked
ATXN3 ataxin 3
BABAM1 BRISC and BRCA1 A complex member 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BARD1 BRCA1 associated RING domain 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCCIP BRCA2 and CDKN1A interacting protein
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTG2 BTG family, member 2
C11ORF30 chromosome 11 open reading frame 30
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
C1ORF86 chromosome 1 open reading frame 86
C9ORF142 chromosome 9 open reading frame 142
CCDC155 coiled-coil domain containing 155
CCNH cyclin H
CCNO cyclin O
CDC14B cell division cycle 14B
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC7 cell division cycle 7
CDCA5 cell division cycle associated 5
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CEP164 centrosomal protein 164kDa
CETN2 centrin, EF-hand protein, 2
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHD1L chromodomain helicase DNA binding protein 1-like
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIB1 calcium and integrin binding 1 (calmyrin)
CINP cyclin-dependent kinase 2 interacting protein
CLSPN claspin
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1D casein kinase 1, delta
CUL4A cullin 4A
CUL4B cullin 4B
DCLRE1A DNA cross-link repair 1A
DCLRE1B DNA cross-link repair 1B
DCLRE1C DNA cross-link repair 1C
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DMAP1 DNA methyltransferase 1 associated protein 1
DNA2 DNA replication helicase/nuclease 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTX3L deltex 3 like, E3 ubiquitin ligase
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1
EID3 EP300 interacting inhibitor of differentiation 3
EME1 essential meiotic structure-specific endonuclease 1
EME2 essential meiotic structure-specific endonuclease subunit 2
ENDOV endonuclease V
EPC2 enhancer of polycomb homolog 2 (Drosophila)
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERCC6L2 excision repair cross-complementation group 6-like 2
ERCC8 excision repair cross-complementation group 8
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
EXO1 exonuclease 1
EXO5 exonuclease 5
EYA1 EYA transcriptional coactivator and phosphatase 1
EYA2 EYA transcriptional coactivator and phosphatase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM175A family with sequence similarity 175, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FANCA Fanconi anemia, complementation group A
FANCB Fanconi anemia, complementation group B
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FBXO6 F-box protein 6
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GEN1 GEN1 Holliday junction 5' flap endonuclease
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTF2H5 general transcription factor IIH, polypeptide 5
H2AFX H2A histone family, member X
HELQ helicase, POLQ-like
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HINFP histone H4 transcription factor
HIST3H2A histone cluster 3, H2a
HLTF helicase-like transcription factor
HMGA2 high mobility group AT-hook 2
HMGN1 high mobility group nucleosome binding domain 1
HUS1 HUS1 checkpoint homolog (S. pombe)
HUS1B HUS1 checkpoint homolog b (S. pombe)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGHMBP2 immunoglobulin mu binding protein 2
INIP INTS3 and NABP interacting protein
INO80 INO80 complex subunit
INO80B INO80 complex subunit B
INO80C INO80 complex subunit C
INO80D INO80 complex subunit D
INO80E INO80 complex subunit E
INTS3 integrator complex subunit 3
JMY junction mediating and regulatory protein, p53 cofactor
KAT5 K(lysine) acetyltransferase 5
KDM2A lysine (K)-specific demethylase 2A
KIAA0101 KIAA0101
KIAA0430 KIAA0430
KIAA2022 KIAA2022
KIF22 kinesin family member 22
KIN Kin17 DNA and RNA binding protein
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MBD4 methyl-CpG binding domain protein 4
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCRS1 microspherule protein 1
MDC1 mediator of DNA-damage checkpoint 1
MEIOB meiosis specific with OB domains
MEN1 multiple endocrine neoplasia I
MGME1 mitochondrial genome maintenance exonuclease 1
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MMS22L MMS22-like, DNA repair protein
MNAT1 MNAT CDK-activating kinase assembly factor 1
MORF4L1 mortality factor 4 like 1
MORF4L2 mortality factor 4 like 2
MPG N-methylpurine-DNA glycosylase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH4 mutS homolog 4
MSH5 mutS homolog 5
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUM1 melanoma associated antigen (mutated) 1
MUS81 MUS81 structure-specific endonuclease subunit
MUTYH mutY homolog
NABP1 nucleic acid binding protein 1
NABP2 nucleic acid binding protein 2
NBN nibrin
NCOA6 nuclear receptor coactivator 6
NDNL2 necdin-like 2
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFRKB nuclear factor related to kappaB binding protein
NHEJ1 nonhomologous end-joining factor 1
NONO non-POU domain containing, octamer-binding
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSMCE1 non-SMC element 1 homolog (S. cerevisiae)
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NTHL1 nth endonuclease III-like 1 (E. coli)
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PALB2 partner and localizer of BRCA2
PAPD7 PAP associated domain containing 7
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PARP9 poly (ADP-ribose) polymerase family, member 9
PARPBP PARP1 binding protein
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PIF1 PIF1 5'-to-3' DNA helicase
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNKP polynucleotide kinase 3'-phosphatase
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
POLN polymerase (DNA directed) nu
POLQ polymerase (DNA directed), theta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP5C protein phosphatase 5, catalytic subunit
PRIMPOL primase and polymerase (DNA-directed)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT6 protein arginine methyltransferase 6
PRPF19 pre-mRNA processing factor 19
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSME4 proteasome (prosome, macropain) activator subunit 4
PTTG1 pituitary tumor-transforming 1
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD21 RAD21 homolog (S. pombe)
RAD21L1 RAD21-like 1 (S. pombe)
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RBBP8 retinoblastoma binding protein 8
RBX1 ring-box 1, E3 ubiquitin protein ligase
RDM1 RAD52 motif containing 1
REC8 REC8 meiotic recombination protein
RECQL RecQ helicase-like
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFWD3 ring finger and WD repeat domain 3
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RNASEH2A ribonuclease H2, subunit A
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPA4 replication protein A4, 30kDa
RPAIN RPA interacting protein
RPS27A ribosomal protein S27a
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RTEL1 regulator of telomere elongation helicase 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SETD2 SET domain containing 2
SETMAR SET domain and mariner transposase fusion gene
SETX senataxin
SFPQ splicing factor proline/glutamine-rich
SFR1 SWI5-dependent recombination repair 1
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIRT1 sirtuin 1
SLC30A9 solute carrier family 30 (zinc transporter), member 9
SLX4 SLX4 structure-specific endonuclease subunit
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMC5 structural maintenance of chromosomes 5
SMC6 structural maintenance of chromosomes 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPIDR scaffolding protein involved in DNA repair
SPRTN SprT-like N-terminal domain
SSRP1 structure specific recognition protein 1
STRA13 stimulated by retinoic acid 13
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SWI5 SWI5 recombination repair homolog (yeast)
SWSAP1 SWIM-type zinc finger 7 associated protein 1
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TCEA1 transcription elongation factor A (SII), 1
TDG thymine-DNA glycosylase
TDP1 tyrosyl-DNA phosphodiesterase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TICRR TOPBP1-interacting checkpoint and replication regulator
TNP1 transition protein 1 (during histone to protamine replacement)
TONSL tonsoku-like, DNA repair protein
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TREX1 three prime repair exonuclease 1
TREX2 three prime repair exonuclease 2
TRIM28 tripartite motif containing 28
TRIP12 thyroid hormone receptor interactor 12
TRIP13 thyroid hormone receptor interactor 13
TRRAP transformation/transcription domain-associated protein
TTC5 tetratricopeptide repeat domain 5
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBE2T ubiquitin-conjugating enzyme E2T
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
USP10 ubiquitin specific peptidase 10
USP28 ubiquitin specific peptidase 28
USP3 ubiquitin specific peptidase 3
USP47 ubiquitin specific peptidase 47
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UVRAG UV radiation resistance associated
UVSSA UV-stimulated scaffold protein A
VCP valosin containing protein
WDR33 WD repeat domain 33
WDR48 WD repeat domain 48
WRN Werner syndrome, RecQ helicase-like
XAB2 XPA binding protein 2
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XRCC6BP1 XRCC6 binding protein 1
YY1 YY1 transcription factor
ZBTB32 zinc finger and BTB domain containing 32
ZFYVE26 zinc finger, FYVE domain containing 26
ZRANB3 zinc finger, RAN-binding domain containing 3
ZSWIM7 zinc finger, SWIM-type containing 7